Universität zu Köln

Sal, Ertan ORCID: 0000-0003-2761-2675, Stemler, Jannik ORCID: 0000-0001-9152-2469, Salmanton-Garcia, Jon, Falces-Romero, Iker, Kredics, Laszlo, Meyer, Elisabeth, Wuerstl, Benjamin, Lass-Floerl, Cornelia, Racil, Zdenek, Klimko, Nikolay, Cesaro, Simone ORCID: 0000-0002-8698-9547, Kindo, Anupma Jyoti, Wisplinghoff, Hilmar, Koehler, Philipp, Cornely, Oliver A. ORCID: 0000-0001-9599-3137 and Seidel, Danila (2022). Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope(R) registry. J. Antimicrob. Chemother., 77 (10). S. 2850 - 2859. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Background Trichoderma spp. are filamentous fungi causing invasive fungal diseases in patients with haematological malignancies and in peritoneal dialysis patients. Objectives To analyse clinical presentation, predisposing factors, treatment and outcome of Trichoderma infections. Methods A systematic literature review was conducted for published cases of invasive Trichoderma infection in PubMed until December 2021 and by reviewing the included studies' references. Cases from the FungiScope(R) registry were added to a combined analysis. Results We identified 50 invasive infections due to Trichoderma species, including 11 in the FungiScope(R) registry. The main underlying conditions were haematological malignancies in 19 and continuous ambulatory peritoneal dialysis (CAPD) in 10 cases. The most prevalent infection sites were lung (42%) and peritoneum (22%). Systemic antifungal therapy was administered in 42 cases (84%), mostly amphotericin B (n = 27, lipid-based formulation 13/27) and voriconazole in 15 cases (30%). Surgical interventions were performed in 13 cases (26%). Overall mortality was 48% (n = 24) and highest for allogeneic HSCT and solid organ transplantation (SOT) recipients [80% (4/5) and 77% (7/9), respectively]. In patients treated with amphotericin B, voriconazole and caspofungin, mortality was 55% (15/27), 46% (7/15) and 28% (2/7), respectively. Three out of four patients treated with a combination therapy of voriconazole and caspofungin survived. Conclusions Despite treatment with antifungal therapies and surgery, invasive Trichoderma infections are life-threatening complications in immunocompromised patients, especially after HSCT and SOT. In addition, Trichoderma spp. mainly affect the lungs in patients with haematological malignancies and the peritoneum in CAPD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sal, Ertan UNSPECIFIED orcid.org/0000-0003-2761-2675 UNSPECIFIED Stemler, Jannik UNSPECIFIED orcid.org/0000-0001-9152-2469 UNSPECIFIED Salmanton-Garcia, Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Falces-Romero, Iker UNSPECIFIED UNSPECIFIED UNSPECIFIED Kredics, Laszlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuerstl, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lass-Floerl, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Racil, Zdenek UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimko, Nikolay UNSPECIFIED UNSPECIFIED UNSPECIFIED Cesaro, Simone UNSPECIFIED orcid.org/0000-0002-8698-9547 UNSPECIFIED Kindo, Anupma Jyoti UNSPECIFIED UNSPECIFIED UNSPECIFIED Wisplinghoff, Hilmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehler, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED orcid.org/0000-0001-9599-3137 UNSPECIFIED Seidel, Danila UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693610
DOI:	10.1093/jac/dkac235
Journal or Publication Title:	J. Antimicrob. Chemother.
Volume:	77
Number:	10
Page Range:	S. 2850 - 2859
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2091
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATIENT; LONGIBRACHIATUM; PERITONITIS; ASPERGILLOSIS Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69361