Universität zu Köln

Kambeitz-Ilankovic, Lana ORCID: 0000-0002-8218-0425, Rzayeva, Uma ORCID: 0000-0002-8294-7171, Voelkel, Laura, Wenzel, Julian, Weiske, Johanna, Jessen, Frank, Reininghaus, Ulrich ORCID: 0000-0002-9227-5436, Uhlhaas, Peter J., Alvarez-Jimenez, Mario and Kambeitz, Joseph ORCID: 0000-0002-8988-3959 (2022). A systematic review of digital and face-to-face cognitive behavioral therapy for depression. npj Digit. Med., 5 (1). BERLIN: NATURE PORTFOLIO. ISSN 2398-6352

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Abstract

Cognitive behavioral therapy (CBT) represents one of the major treatment options for depressive disorders besides pharmacological interventions. While newly developed digital CBT approaches hold important advantages due to higher accessibility, their relative effectiveness compared to traditional CBT remains unclear. We conducted a systematic literature search to identify all studies that conducted a CBT-based intervention (face-to-face or digital) in patients with major depression. Random-effects meta-analytic models of the standardized mean change using raw score standardization (SMCR) were computed. In 106 studies including n = 11854 patients face-to-face CBT shows superior clinical effectiveness compared to digital CBT when investigating depressive symptoms (p < 0.001, face-to-face CBT: SMCR = 1.97, 95%-CI: 1.74-2.13, digital CBT: SMCR = 1.20, 95%-CI: 1.08-1.32) and adherence (p = 0.014, face-to-face CBT: 82.4%, digital CBT: 72.9%). However, after accounting for differences between face-to-face and digital CBT studies, both approaches indicate similar effectiveness. Important variables with significant moderation effects include duration of the intervention, baseline severity, adherence and the level of human guidance in digital CBT interventions. After accounting for potential confounders our analysis indicates comparable effectiveness of face-to-face and digital CBT approaches. These findings underline the importance of moderators of clinical effects and provide a basis for the future personalization of CBT treatment in depression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kambeitz-Ilankovic, Lana UNSPECIFIED orcid.org/0000-0002-8218-0425 UNSPECIFIED Rzayeva, Uma UNSPECIFIED orcid.org/0000-0002-8294-7171 UNSPECIFIED Voelkel, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiske, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Reininghaus, Ulrich UNSPECIFIED orcid.org/0000-0002-9227-5436 UNSPECIFIED Uhlhaas, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alvarez-Jimenez, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED orcid.org/0000-0002-8988-3959 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693729
DOI:	10.1038/s41746-022-00677-8
Journal or Publication Title:	npj Digit. Med.
Volume:	5
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2398-6352
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERPERSONAL PSYCHOTHERAPY; PSYCHOLOGICAL TREATMENTS; SMARTPHONE APPS; INTERNET; METAANALYSIS; EFFICACY; PREDICTORS; INTERVENTIONS; MODERATORS; DISORDERS Multiple languages Health Care Sciences & Services; Medical Informatics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69372