Universität zu Köln

Singh, Karmveer, Maity, Pallab ORCID: 0000-0001-9769-3533, Koroma, Albert Kallon, Basu, Abhijit, Pandey, Rajeev Kumar ORCID: 0000-0002-1368-323X, Vander Beken, Seppe, Haas, Philipp, Krug, Linda, Hainzl, Adelheid, Sindrilaru, Anca ORCID: 0000-0002-1691-0047, Pfeiffer, Christiane, Wlaschek, Meinhard, Frank, Natasha Y., Frank, Markus H., Ganss, Christoph, Banvolgyi, Andras, Wikonkal, Norbert, Eming, Sabine, Pastar, Irena, Tomic-Canic, Marjana, Kluth, Mark A. and Scharffetter-Kochanek, Karin (2022). Angiogenin Released from ABCB5(+)( )Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis. J. Invest. Dermatol., 142 (6). S. 1725 - 1747. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1523-1747

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Abstract

Severe angiopathy is a major driver for diabetes-associated secondary complications. Knowledge on the underlying mechanisms essential for advanced therapies to attenuate these pathologies is limited. Injection of ABCB5+ stromal precursors at the edge of nonhealing diabetic wounds in a murine db/db model, closely mirroring human type 2 diabetes, profoundly accelerates wound closure. Strikingly, enhanced angiogenesis was substantially enforced by the release of the ribonuclease angiogenin from ABCB5+ stromal precursors. This compensates for the profoundly reduced angiogenin expression in nontreated murine chronic diabetic wounds. Silencing of angiogenin in ABCB5+ stromal precursors before injection significantly reduced angiogenesis and delayed wound closure in diabetic db/db mice, implying an unprecedented key role for angiogenin in tissue regeneration in diabetes. These data hold significant promise for further refining stromal precursors-based therapies of nonhealing diabetic foot ulcers and other pathologies with impaired angiogenesis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Singh, Karmveer UNSPECIFIED UNSPECIFIED UNSPECIFIED Maity, Pallab UNSPECIFIED orcid.org/0000-0001-9769-3533 UNSPECIFIED Koroma, Albert Kallon UNSPECIFIED UNSPECIFIED UNSPECIFIED Basu, Abhijit UNSPECIFIED UNSPECIFIED UNSPECIFIED Pandey, Rajeev Kumar UNSPECIFIED orcid.org/0000-0002-1368-323X UNSPECIFIED Vander Beken, Seppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Hainzl, Adelheid UNSPECIFIED UNSPECIFIED UNSPECIFIED Sindrilaru, Anca UNSPECIFIED orcid.org/0000-0002-1691-0047 UNSPECIFIED Pfeiffer, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Wlaschek, Meinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Natasha Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Markus H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganss, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Banvolgyi, Andras UNSPECIFIED UNSPECIFIED UNSPECIFIED Wikonkal, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Pastar, Irena UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomic-Canic, Marjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Kluth, Mark A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scharffetter-Kochanek, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693786
DOI:	10.1016/j.jid.2021.10.026
Journal or Publication Title:	J. Invest. Dermatol.
Volume:	142
Number:	6
Page Range:	S. 1725 - 1747
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1523-1747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM; PHOSPHORYLATION; REGENERATION; RESISTANCE; KINASE; CELLS; GENE Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69378