Universität zu Köln

Giraudier, Manon ORCID: 0000-0003-0159-1925, Ventura-Bort, Carlos, Burger, Andreas M., Claes, Nathalie ORCID: 0000-0002-8615-8436, D'Agostini, Martina ORCID: 0000-0003-1383-7638, Fischer, Rico, Franssen, Mathijs, Kaess, Michael ORCID: 0000-0003-0031-7764, Koenig, Julian, Liepelt, Roman ORCID: 0000-0002-4656-6267, Nieuwenhuis, Sander, Sommer, Aldo, Usichenko, Taras, Van Diest, Ilse ORCID: 0000-0002-0048-774X, von Leupoldt, Andreas, Warren, Christopher M. and Weymar, Mathias ORCID: 0000-0002-3968-9656 (2022). Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis. Brain Stimul., 15 (6). S. 1378 - 1389. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-4754

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Abstract

Background: Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet.Methods: The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release.Results: While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity.Conclusion(s): Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.(c) 2022 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Giraudier, Manon UNSPECIFIED orcid.org/0000-0003-0159-1925 UNSPECIFIED Ventura-Bort, Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Burger, Andreas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Claes, Nathalie UNSPECIFIED orcid.org/0000-0002-8615-8436 UNSPECIFIED D'Agostini, Martina UNSPECIFIED orcid.org/0000-0003-1383-7638 UNSPECIFIED Fischer, Rico UNSPECIFIED UNSPECIFIED UNSPECIFIED Franssen, Mathijs UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaess, Michael UNSPECIFIED orcid.org/0000-0003-0031-7764 UNSPECIFIED Koenig, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt, Roman UNSPECIFIED orcid.org/0000-0002-4656-6267 UNSPECIFIED Nieuwenhuis, Sander UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Aldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Usichenko, Taras UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Diest, Ilse UNSPECIFIED orcid.org/0000-0002-0048-774X UNSPECIFIED von Leupoldt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Warren, Christopher M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymar, Mathias UNSPECIFIED orcid.org/0000-0002-3968-9656 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693819
DOI:	10.1016/j.brs.2022.09.009
Journal or Publication Title:	Brain Stimul.
Volume:	15
Number:	6
Page Range:	S. 1378 - 1389
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-4754
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCUS-COERULEUS; ELECTRICAL-STIMULATION; CONDITIONED FEAR; PUPIL-DILATION; NOREPINEPHRINE; MEMORY; RAT; EXTINCTION; ACTIVATION; BIOMARKER Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69381