Universität zu Köln

Kaufmann, Ernest, Antonelli, Luca, Albers, Peter, Cary, Clint, Sommer, Silke Gillessen, Heidenreich, Axel, Oing, Christoph, Oldenburg, Jan, Pierorazio, Phillip Martin, Stephenson, Andrew J. and Fankhauser, Christian Daniel (2022). Oncological Follow-up Strategies for Testicular Germ Cell Tumours: A Narrative Review. Eur. Urol. Open Sci., 44. S. 142 - 150. AMSTERDAM: ELSEVIER. ISSN 2666-1683

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Abstract

Context: The aim of this review is to describe the proportion of testicular germ cell tumours (tGCTs) with recurrence, and the timing and anatomical sites of relapse across different disease stages and after different treatment options. We sum-marise published follow-up protocols and discuss current and future developments to personalise follow-up for patients with tGCT. Evidence acquisition: A systematic literature search was conducted and current guidelines and selected institutional follow-up protocols were reviewed. Evidence synthesis: Of 302 publications, we screened 68 full texts and included 29 studies; 22 of these were retrospective and seven were prospective in nature, con-tributing data for 20 570 patients. The number of patients included per study ran-ged from 119 to 2483. We compared the guideline follow-up protocols of the European Society for Medical Oncology, European Association of Urology, National Comprehensive Cancer Network, and American Urological Association, as well as institutional follow-up protocols. The protocols differed in terms of the number, time points, and type of follow-up investigations. Conclusions: Future research should assess how tGCT can be followed to ensure high adherence, define the role of miR-371a-3p microRNA during follow-up, and develop follow-up protocols after curative treatment in the metastatic setting. Patient summary: In this review of follow-up protocols for men with testis cancer, we observed different recommendations and discuss future research areas to improve follow-up for these patients. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kaufmann, Ernest UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonelli, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Albers, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Cary, Clint UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Silke Gillessen UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Oing, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Oldenburg, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Pierorazio, Phillip Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephenson, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fankhauser, Christian Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693822
DOI:	10.1016/j.euros.2022.08.014
Journal or Publication Title:	Eur. Urol. Open Sci.
Volume:	44
Page Range:	S. 142 - 150
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2666-1683
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE-I SEMINOMA; LATE-RELAPSE; ADJUVANT CARBOPLATIN; TESTIS CANCER; RISK-FACTORS; SURVEILLANCE; PATTERNS; RECURRENCE; MANAGEMENT; CHEMOTHERAPY Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69382