Universität zu Köln

Schirmbeck, Frederike, van der Ven, Els ORCID: 0000-0001-5103-7186, Boyette, Lindy-Lou, McGuire, Philip ORCID: 0000-0003-4381-0532, Valmaggia, Lucia R., Kempton, Matthew J., van der Gaag, Mark, Riecher-Rossler, Anita, Barrantes-Vidal, Neus, Nelson, Barnaby, Krebs, Marie-Odile, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Sachs, Gabriele, Rutten, Bart P. F., Nordentoft, Merete, de Haan, Lieuwe and Vermeulen, Jentien M. (2022). Differential trajectories of tobacco smoking in people at ultra-high risk for psychosis: Associations with clinical outcomes. Front. Psychiatry, 13. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

ObjectivePeople at ultra-high risk (UHR) for psychosis have a high prevalence of tobacco smoking, and rates are even higher among the subgroup that later develop a psychotic disorder. However, the longitudinal relationship between the course of tobacco smoking and clinical outcomes in UHR subjects is unknown. MethodsWe investigated associations between tobacco smoking and clinical outcomes in a prospective study of UHR individuals (n = 324). Latent class mixed model analyses were used to identify trajectories of smoking severity. Mixed effects models were applied to investigate associations between smoking trajectory class and the course of attenuated psychotic symptoms (APS) and affective symptoms, as assessed using the CAARMS. ResultsWe identified four different classes of smoking trajectory: (i) Persistently High (n = 110), (ii) Decreasing (n = 29), (iii) Persistently Low (n = 165) and (iv) Increasing (n = 20). At two-year follow-up, there had been a greater increase in APS in the Persistently High class than for both the Persistently Low (ES = 9.77, SE = 4.87, p = 0.046) and Decreasing (ES = 18.18, SE = 7.61, p = 0.018) classes. There were no differences between smoking classes in the incidence of psychosis. There was a greater reduction in the severity of emotional disturbance and general symptoms in the Decreasing class than in the High (ES = -10.40, SE = 3.41, p = 0.003; ES = -22.36, SE = 10.07, p = 0.027), Increasing (ES = -11.35, SE = 4.55, p = 0.014; ES = -25.58, SE = 13.17, p = 0.050) and Low (ES = -11.38, SE = 3.29, p = 0.001; ES = -27.55, SE = 9.78, p = 0.005) classes, respectively. ConclusionsThese findings suggests that in UHR subjects persistent tobacco smoking is associated with an unfavorable course of psychotic symptoms, whereas decrease in the number of cigarettes smoked is associated with improvement in affective symptoms. Future research into smoking cessation interventions in the early stages of psychoses is required to shine light on the potential of modifying smoking behavior and its relation to clinical outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schirmbeck, Frederike UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Ven, Els UNSPECIFIED orcid.org/0000-0001-5103-7186 UNSPECIFIED Boyette, Lindy-Lou UNSPECIFIED UNSPECIFIED UNSPECIFIED McGuire, Philip UNSPECIFIED orcid.org/0000-0003-4381-0532 UNSPECIFIED Valmaggia, Lucia R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kempton, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Riecher-Rossler, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrantes-Vidal, Neus UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelson, Barnaby UNSPECIFIED UNSPECIFIED UNSPECIFIED Krebs, Marie-Odile UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Sachs, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Rutten, Bart P. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordentoft, Merete UNSPECIFIED UNSPECIFIED UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeulen, Jentien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693947
DOI:	10.3389/fpsyt.2022.869023
Journal or Publication Title:	Front. Psychiatry
Volume:	13
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-0640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOBAL ASSESSMENT; RELIABILITY; VALIDITY; SCHIZOPHRENIA; INDIVIDUALS; EXPERIENCES; CANNABIS; MODELS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69394