Universität zu Köln

Hong, Wonju, White, P. Lewis, Backx, Matthijs, Gangneux, Jean-Pierre ORCID: 0000-0002-4974-5607, Reizine, Florian, Koehler, Philipp, Bentvelsen, Robbert G., Cuestas, Maria Lujan, Fakhim, Hamed, Jung, Jung Im, Lee, Young Kyung, Dalsania, Nishil R., Patti, Ravi Karan and Yoon, Soon Ho (2022). CT findings of COVID-19-associated pulmonary aspergillosis: a systematic review and individual patient data analysis. Clin. Imaging, 90. S. 11 - 19. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4499

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Abstract

Purpose: Common CT abnormalities of pulmonary aspergillosis represent a cavity with air-meniscus sign, nodule, mass, and consolidation having an angio-invasive pattern. This study aims to conduct a systematic review and an individual patient-level image analysis of CT findings of COVID-19-associated pulmonary aspergillosis (CAPA).Methods: A systematic literature search was conducted to identify studies reporting CT findings of CAPA as of January 7, 2021. We summarized study-level clinical and CT findings of CAPA and collected individual patient CT images by inviting corresponding authors. The CT findings were categorized into four groups: group 1, typical appearance of COVID-19; group 2, indeterminate appearance of COVID-19; group 3, atypical for COVID-19 without cavities; and group 4, atypical for COVID-19 with cavities. In group 2, cases had only minor discrepant findings including solid nodules, isolated airspace consolidation with negligible ground-glass opaci-ties, centrilobular micronodules, bronchial abnormalities, and cavities. Results: The literature search identified 89 patients from 25 studies, and we collected CT images from 35 CAPA patients (mean age 62.4 +/- 14.6 years; 21 men): group 1, thirteen patients (37.1%); group 2, eight patients (22.9%); group 3, six patients (17.1%); and group 4, eight patients (22.9%). Eight of the 14 patients (57.1%) with an atypical appearance had bronchial abnormalities, whereas only one (7.1%) had an angio-invasive fungal pattern. In the study-level analysis, cavities were reported in 12 of 54 patients (22.2%).Conclusion: CAPA can frequently manifest as COVID-19 pneumonia without common CT abnormalities of pul-monary aspergillosis. If abnormalities exist on CT images, CAPA may frequently accompany bronchial abnormalities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hong, Wonju UNSPECIFIED UNSPECIFIED UNSPECIFIED White, P. Lewis UNSPECIFIED UNSPECIFIED UNSPECIFIED Backx, Matthijs UNSPECIFIED UNSPECIFIED UNSPECIFIED Gangneux, Jean-Pierre UNSPECIFIED orcid.org/0000-0002-4974-5607 UNSPECIFIED Reizine, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehler, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Bentvelsen, Robbert G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cuestas, Maria Lujan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fakhim, Hamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Jung Im UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Young Kyung UNSPECIFIED UNSPECIFIED UNSPECIFIED Dalsania, Nishil R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patti, Ravi Karan UNSPECIFIED UNSPECIFIED UNSPECIFIED Yoon, Soon Ho UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-693978
DOI:	10.1016/j.clinimag.2022.07.003
Journal or Publication Title:	Clin. Imaging
Volume:	90
Page Range:	S. 11 - 19
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-4499
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COVID-19; SPECTRUM; DISEASE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69397