Universität zu Köln

Jacob, Anne Sophie, Kaul, Helen, Fuchs, Michael, Gillessen, Sarah, Kreissl, Stefanie, Pluetschow, Annette, Momotow, Jesko, Schaub, Valdete, Huettmann, Andreas, Haenel, Mathias, Zimmermann, Andreas, Dierlamm, Judith, Meissner, Julia, Mathas, Stephan, Martin, Sonja, Engert, Andreas, Hallek, Michael ORCID: 0000-0002-7425-4455, Borchmann, Peter and Lehmann, Clara (2022). Impact of the first COVID-19 lockdown in Germany on the rate of acute infections during intensive chemotherapy for Hodgkin lymphoma. Infection, 50 (4). S. 925 - 933. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Purpose Evidence on the effect of self-protection via social distancing and wearing face-masks on infections during chemotherapy is currently not available. We asked if the occurrence of acute infections during chemotherapy for advanced-stage Hodgkin lymphoma (HL) decreased when COVID-19 protection measures were in effect. Methods We analyzed the occurrence of infections during all documented eBEACOPP cycles starting between 01 March and 30 June of 2017 to 2020 in patients treated within the GHSG HD21 study in Germany and compared the infection rates and characteristics by logistic regression models and means of descriptive statistics. Results We analyzed 911 cycles of 313 adult patients treated with 4 to 6 cycles of eBEACOPP. We found a significant decrease in the occurrence of infections during chemotherapy for HL during COVID-19 lockdown from 131 (19.6%) of 670 cycles in 2017-2019 to 30 (12.6%) of 239 cycles during COVID-19 lockdown [OR 0.574 (95% CI 0.354-0.930), P = 0.024]. The strongest effect was evident for unspecified infections with 39 cycles (5.8%) during 2017-2019 in comparison to 5 cycles (2.1%) during COVID-19 lockdown. 20 (24.1%) of 83 patients had an infection during the COVID-19 lockdown versus 99 (43.2%) of 229 patients in the years 2017-2019 (P = 0.0023). Conclusion The significant decrease of infections during chemotherapy for HL during COVID-19 lockdown reveals the protective measures' potential to shield patients from transmissible pathogens. We conclude that these measures could be recommended for HL patients at risk for infections during chemotherapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jacob, Anne Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaul, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillessen, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreissl, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pluetschow, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Momotow, Jesko UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Valdete UNSPECIFIED UNSPECIFIED UNSPECIFIED Huettmann, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Haenel, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmermann, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dierlamm, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathas, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED orcid.org/0000-0002-7425-4455 UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694050
DOI:	10.1007/s15010-022-01765-3
Journal or Publication Title:	Infection
Volume:	50
Number:	4
Page Range:	S. 925 - 933
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FEBRILE NEUTROPENIA; OPEN-LABEL; TRIAL Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69405