Sibert, Nora Tabea, Pfaff, Holger ORCID: 0000-0001-9154-6575, Breidenbach, Clara, Wesselmann, Simone, Roth, Rebecca ORCID: 0000-0002-2841-4921, Feick, Guenther, Carl, Guenter, Dieng, Sebastian, Gaber, Amr A., Blana, Andreas, Darr, Christopher, Distler, Florian, Kunath, Frank, Bedke, Jens ORCID: 0000-0003-2778-3108, Erdmann, Joerg, Minner, Joerg, Simon, Joerg, Kwiatkowski, Maciej, Burchardt, Martin, Harz, Nino, Conrad, Stefan, Hoefner, Thomas, Knoll, Thomas, Beyer, Burkhard, Hammerer, Peter and Kowalski, Christoph (2022). Variation across operating sites in urinary and sexual outcomes after radical prostatectomy in localized and locally advanced prostate cancer. World J. Urol., 40 (6). S. 1437 - 1447. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Purpose The extent of variation in urinary and sexual functional outcomes after radical prostatectomy (RPE) between prostate cancer (PC) operating sites remains unknown. Therefore, this analysis aims to compare casemix-adjusted functional outcomes (EPIC-26 scores incontinence, irritative/obstructive function and sexual function) between operating sites 12 months after RPE. Materials and methods Analysis of a cohort of 7065 men treated with RPE at 88 operating sites (prostate cancer centers, PCCs) between 2016 and 2019. Patients completed EPIC-26 and sociodemographic information surveys at baseline and 12 months after RPE. Survey data were linked to clinical data. EPIC-26 domain scores at 12 months after RPE were adjusted for relevant confounders (including baseline domain score, clinical and sociodemographic information) using regression analysis. Differences between sites were described using minimal important differences (MIDs) and interquartile ranges (IQR). The effects of casemix adjustment on the score results were described using Cohen's d and MIDs. Results Adjusted domain scores at 12 months varied between sites, with IQRs of 66-78 (incontinence), 89-92 (irritative/obstructive function), and 20-29 (sexual function). Changes in domain scores after casemix adjustment for sites >= 1 MID were noted for the incontinence domain (six sites). Cohen's d ranged between - 0.07 (incontinence) and - 0.2 (sexual function), indicating a small to medium effect of casemix adjustment. Conclusions Variation between sites was greatest in the incontinence and sexual function domains for RPE patients. Future research will need to identify the factors contributing to this variation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sibert, Nora TabeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaff, HolgerUNSPECIFIEDorcid.org/0000-0001-9154-6575UNSPECIFIED
Breidenbach, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wesselmann, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, RebeccaUNSPECIFIEDorcid.org/0000-0002-2841-4921UNSPECIFIED
Feick, GuentherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carl, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dieng, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaber, Amr A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blana, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Darr, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunath, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedke, JensUNSPECIFIEDorcid.org/0000-0003-2778-3108UNSPECIFIED
Erdmann, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minner, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kwiatkowski, MaciejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burchardt, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harz, NinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conrad, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoefner, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoll, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyer, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammerer, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kowalski, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-694519
DOI: 10.1007/s00345-022-03985-6
Journal or Publication Title: World J. Urol.
Volume: 40
Number: 6
Page Range: S. 1437 - 1447
Date: 2022
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1433-8726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PATIENT-REPORTED OUTCOMES; EXTERNAL-BEAM RADIATION; QUALITY-OF-LIFE; FUNCTIONAL OUTCOMES; THERAPY; SURGERY; VALIDATION; MENMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69451

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