Universität zu Köln

Wu, Zhichao, Pfau, Maximilian ORCID: 0000-0001-9761-9640, Blodi, Barbara A., Holz, Frank G., Jaffe, Glenn J., Liakopoulos, Sandra, Sadda, Srinivas R., Staurenghi, Giovanni, Bjelopera, Elvira, Brown, Tyler, Chang, Petrus, Choong, John, Corradetti, Giulia, Corvi, Federico ORCID: 0000-0002-2661-5500, Domalpally, Amitha, Hurtenbach, Cynthia, Nittala, Muneeswar Gupta, Olson, Anthony, Pak, Jeong W., Pappe, Judith, Sassmannshausen, Marlene, Skalak, Cindy, Thiele, Sarah, Guymer, Robyn H. and Schmitz-Valckenberg, Steffen (2022). OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement Classification of Atrophy Meetings Report 6. Ophthalmol. Retina, 6 (1). S. 4 - 15. SAN DIEGO: ELSEVIER INC. ISSN 2468-6530

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Abstract

Purpose: To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD). Design: Interreader agreement study. Participants: Twelve readers from 6 reading centers. Methods: After formal training, readers qualitatively assessed 60 OCT B-scans from 60 eyes with AMD for 9 individual features associated with early atrophy and performed 7 different annotations to quantify the spatial extent of OCT features within regions of interest. The qualitative and quantitative features were used to derive the presence of iRORA and cRORA and also in an exploratory analysis to examine if agreement could be improved using different combinations of features to define OCT atrophy. Main Outcome Measures: Interreader agreement based on Gwet's first-order agreement coefficient (AC(1)) for qualitatively graded OCT features and classification of iRORA and cRORA, and smallest real difference (SRD) for quantitatively graded OCT features. Results: Substantial or better interreader agreement was observed for all qualitatively graded OCT features associated with atrophy (AC(1) = 0.63-0.87), except for RPE attenuation (AC(1) = 0.46) and disruption (AC(1) = 0.26). The lowest SRD for the quantitatively graded horizontal features was observed for the zone of choroidal hyper-transmission (+/- 190.8 mu m). Moderate agreement was found for a 3-category classification of no atrophy, iRORA, and cRORA (AC(1) = 0.53). Exploratory analyses suggested a significantly higher level of agreement for a 3-category classification using (1) no atrophy; (2) presence of inner nuclear layer and outer plexiform layer subsidence, or a hyporeflective wedge-shaped band, as a less severe atrophic grade; and (3) the latter plus an additional requirement of choroidal hypertransmission of 250 mu m or more for a more severe atrophic grade (AC(1) = 0.68; P = 0.013). Conclusions: Assessment of iRORA and cRORA, and most of their associated features, can be performed relatively consistently and robustly. A refined combination of features to define early atrophy could further improve interreader agreement. (C) 2021 by the American Academy of Ophthalmology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wu, Zhichao UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfau, Maximilian UNSPECIFIED orcid.org/0000-0001-9761-9640 UNSPECIFIED Blodi, Barbara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holz, Frank G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaffe, Glenn J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Sadda, Srinivas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Staurenghi, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Bjelopera, Elvira UNSPECIFIED UNSPECIFIED UNSPECIFIED Brown, Tyler UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, Petrus UNSPECIFIED UNSPECIFIED UNSPECIFIED Choong, John UNSPECIFIED UNSPECIFIED UNSPECIFIED Corradetti, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Corvi, Federico UNSPECIFIED orcid.org/0000-0002-2661-5500 UNSPECIFIED Domalpally, Amitha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hurtenbach, Cynthia UNSPECIFIED UNSPECIFIED UNSPECIFIED Nittala, Muneeswar Gupta UNSPECIFIED UNSPECIFIED UNSPECIFIED Olson, Anthony UNSPECIFIED UNSPECIFIED UNSPECIFIED Pak, Jeong W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappe, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Sassmannshausen, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Skalak, Cindy UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Guymer, Robyn H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz-Valckenberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694526
DOI:	10.1016/j.oret.2021.03.008
Journal or Publication Title:	Ophthalmol. Retina
Volume:	6
Number:	1
Page Range:	S. 4 - 15
Date:	2022
Publisher:	ELSEVIER INC
Place of Publication:	SAN DIEGO
ISSN:	2468-6530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; GEOGRAPHIC ATROPHY; INTEROBSERVER AGREEMENT; FUNDUS AUTOFLUORESCENCE; CLASSIFICATION; PROGRESSION; FEATURES Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69452