Universität zu Köln

Hartung, Tim J., Neumann, Christian, Bahmer, Thomas, Chaplinskaya-Sobol, Irina, Endres, Matthias ORCID: 0000-0001-6520-3720, Geritz, Johanna, Haeusler, Karl Georg, Heuschmann, Peter U., Hildesheim, Hanna, Hinz, Andreas, Hopff, Sina, Horn, Anna, Krawczak, Michael, Krist, Lilian ORCID: 0000-0002-6089-5163, Kudelka, Jennifer, Lieb, Wolfgang, Maetzler, Corina, Mehnert-Theuerkauf, Anja ORCID: 0000-0002-6872-9805, Montellano, Felipe A. ORCID: 0000-0002-9438-0854, Morbach, Caroline, Schmidt, Sein, Schreiber, Stefan, Steigerwald, Flo, Stoerk, Stefan, Maetzler, Walter and Finke, Carsten (2022). Fatigue and cognitive impairment after COVID-19: A prospective multicentre study. EClinicalMedicine, 53. AMSTERDAM: ELSEVIER. ISSN 2589-5370

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Abstract

Background Reliable estimates of frequency, severity and associated factors of both fatigue and cognitive impairment after COVID-19 are needed. Also, it is not clear whether the two are distinct sequelae of COVID-19 or part of the same syndrome. Methods In this prospective multicentre study, frequency of post-COVID fatigue and cognitive impairment were assessed in n = 969 patients (535 [55%] female) >= 6 months after SARS-CoV-2 infection with the FACIT-Fatigue scale (cut-off <= 30) and Montreal Cognitive Assessment (<= 25 mild, <= 17 moderate impairment) between November 15, 2020 and September 29, 2021 at University Medical Center Schleswig-Holstein, Campus Kiel and University Hospital Wu euro rzburg in Germany. 969 matched non-COVID controls were drawn from a pre-pandemic, randomised, Germany-wide population survey which also included the FACIT-Fatigue scale. Associated sociodemographic, comorbid, clinical, psychosocial factors and laboratory markers were identified with univariate and multivariable linear regression models. Findings On average 9 months after infection, 19% of patients had clinically relevant fatigue, compared to 8% of matched non-COVID controls (p < 0.001). Factors associated with fatigue were female gender, younger age, history of depression and the number of acute COVID symptoms. Among acute COVID symptoms, altered consciousness, dizziness and myalgia were most strongly associated with long-term fatigue. Moreover, 26% of patients had mild and 1% had moderate cognitive impairment. Factors associated with cognitive impairment were older age, male gen-der, shorter education and a history of neuropsychiatric disease. There was no significant correlation between fatigue and cognitive impairment and only 5% of patients suffered from both conditions. Interpretation Fatigue and cognitive impairment are two common, but distinct sequelae of COVID-19 with potentially separate pathophysiological pathways. Copyright (c) 2022 The Author(s). Published by Elsevier Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hartung, Tim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahmer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaplinskaya-Sobol, Irina UNSPECIFIED UNSPECIFIED UNSPECIFIED Endres, Matthias UNSPECIFIED orcid.org/0000-0001-6520-3720 UNSPECIFIED Geritz, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeusler, Karl Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Heuschmann, Peter U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hildesheim, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinz, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hopff, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Krawczak, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Krist, Lilian UNSPECIFIED orcid.org/0000-0002-6089-5163 UNSPECIFIED Kudelka, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Lieb, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Maetzler, Corina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mehnert-Theuerkauf, Anja UNSPECIFIED orcid.org/0000-0002-6872-9805 UNSPECIFIED Montellano, Felipe A. UNSPECIFIED orcid.org/0000-0002-9438-0854 UNSPECIFIED Morbach, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Sein UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiber, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Steigerwald, Flo UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoerk, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Maetzler, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Finke, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-694734
DOI:	10.1016/j.eclinm.2022.101651
Journal or Publication Title:	EClinicalMedicine
Volume:	53
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2589-5370
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL ASSESSMENT; NORMATIVE DATA Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69473