Moldt, Brian, Gunthard, Huldrych F., Workowski, Kimberly A., Little, Susan J., Eron, Joseph J., Overton, Edgar T., Lehmann, Clara ORCID: 0000-0002-7042-1578, Rokx, Casper, Kozal, Michael J., Gandhi, Rajesh T., Braun, Dominique L., Parvangada, Aiyappa, Li, Jiani, Martin, Ross, Selzer, Lisa, Cox, Stephanie, Margot, Nicolas, Liu, Hui, Slamowitz, Debbie, Makadzange, Tariro, Collins, Sean E., Geleziunas, Romas and Callebaut, Christian (2022). Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals. Aids, 36 (2). S. 205 - 215. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

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Abstract

Objective: Persistence of the viral reservoir is the main barrier to curing HIV. Initiation of ART during acute HIV infection can limit the size and diversity of the reservoir. In depth characterization of the reservoir in individuals who initiate ART during acute infection will be critical for clinical trial design and cure strategies. Methods: Four cohorts with participants who initiated ART during acute infection or during chronic infection were enrolled in a cross-sectional, noninterventional study. Viral reservoir was evaluated by the Intact Proviral DNA Assay (IPDA), the Total HIV DNA Assay (THDA) and the Quantitative Viral Outgrowth Assay (QVOA). Viral diversity and susceptibility to V3-glycan bNAbs were determined by genotyping of the viral envelope gene. Results: Participants who initiated ART during the acute Fiebig I-IV stages had lower level of total HIV DNA than participants who initiated ART during chronic infection whereas no difference was observed in intact HIV DNA or outgrowth virus. Participants who initiated ART during Fiebig I-IV also had lower viral diversity and appeared to have higher susceptibility to bNAbs than participants initiating ART during chronic infection. Conclusion: Individuals initiating ART during Fiebig I-IV had small viral reservoirs, low viral diversity, and high susceptibility to bNAbs, and would be an optimal target population for proof-of-concept HIV cure trials.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moldt, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gunthard, Huldrych F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Workowski, Kimberly A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Little, Susan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eron, Joseph J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Overton, Edgar T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDorcid.org/0000-0002-7042-1578UNSPECIFIED
Rokx, CasperUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozal, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gandhi, Rajesh T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, Dominique L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parvangada, AiyappaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, JianiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, RossUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Selzer, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margot, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, HuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slamowitz, DebbieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makadzange, TariroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collins, Sean E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geleziunas, RomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Callebaut, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-694911
DOI: 10.1097/QAD.0000000000003088
Journal or Publication Title: Aids
Volume: 36
Number: 2
Page Range: S. 205 - 215
Date: 2022
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5571
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTACT PROVIRAL DNA; LATENT HIV-1; IN-VIVO; DIVERSITY; INFECTION; FREQUENCY; DYNAMICS; PROVIDES; VIREMIA; BLOODMultiple languages
Immunology; Infectious Diseases; VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69491

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