Universität zu Köln

Assa, Amit, Borrelli, Osvaldo, Broekaert, Ilse, Saccomani, Marco Deganello, Dolinsek, Jernej, Martin-de-Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Sila, Sara, Thomson, Mike, Tzivinikos, Christos and Benninga, Marc A. (2022). Helicobacter pylori-negative Chronic Gastritis in Children: A Systematic Review. J. Pediatr. Gastroenterol. Nutr., 74 (5). S. 956 - 968. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4801

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Abstract

Objectives: To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes. Methods: Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included. Results: A total of 54 studies were included consisted of eosinophilic gastritis (n = 9), autoimmune gastritis (n = 11), collagenous gastritis (n = 16), focally enhanced gastritis (n = 6), lymphocytic gastritis (n = 5) and other causes including idiopathic gastritis and chronic renal failure related (n = 7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%-45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses. Conclusions: Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Assa, Amit UNSPECIFIED UNSPECIFIED UNSPECIFIED Borrelli, Osvaldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse UNSPECIFIED UNSPECIFIED UNSPECIFIED Saccomani, Marco Deganello UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolinsek, Jernej UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin-de-Carpi, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Mas, Emmanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Miele, Erasmo UNSPECIFIED UNSPECIFIED UNSPECIFIED Sila, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzivinikos, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695135
DOI:	10.1097/MPG.0000000000003414
Journal or Publication Title:	J. Pediatr. Gastroenterol. Nutr.
Volume:	74
Number:	5
Page Range:	S. 956 - 968
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4801
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOCALLY ENHANCED GASTRITIS; AUTOIMMUNE ATROPHIC GASTRITIS; EOSINOPHILIC GASTROINTESTINAL DISORDERS; INFLAMMATORY-BOWEL-DISEASE; IRON-DEFICIENCY ANEMIA; COLLAGENOUS GASTRITIS; LYMPHOCYTIC GASTRITIS; CROHNS-DISEASE; CELIAC-DISEASE; GASTRODUODENAL LESIONS Multiple languages Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69513