Universität zu Köln

Ganos, Christos ORCID: 0000-0001-8077-8530, Al-Fatly, Bassam ORCID: 0000-0003-0067-6177, Fischer, Jan-Frederik, Baldermann, Juan-Carlos, Hennen, Christina ORCID: 0000-0003-2091-4638, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Neudorfer, Clemens, Martino, Davide, Li, Jing, Bouwens, Tim, Ackermanns, Linda, Leentjens, Albert F. G., Pyatigorskaya, Nadya, Worbe, Yulia, Fox, Michael D. ORCID: 0000-0001-8848-6399, Kuehn, Andrea A. and Horn, Andreas ORCID: 0000-0002-0695-6025 (2022). A neural network for tics: insights from causal brain lesions and deep brain stimulation. Brain, 145 (12). S. 4385 - 4398. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2156

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Abstract

Brain lesions are a rare cause of tic disorders. However, they can provide uniquely causal insights into tic pathophysiology and can also inform on possible neuromodulatory therapeutic targets. Based on a systematic literature review, we identified 22 cases of tics causally attributed to brain lesions and employed 'lesion network mapping' to interrogate whether tic-inducing lesions would be associated with a common network in the average human brain. We probed this using a normative functional connectome acquired in 1000 healthy participants. We then examined the specificity of the identified network by contrasting tic-lesion connectivity maps to those seeding from 717 lesions associated with a wide array of neurological and/or psychiatric symptoms within the Harvard Lesion Repository. Finally, we determined the predictive utility of the tic-inducing lesion network as a therapeutic target for neuromodulation. Specifically, we collected retrospective data of 30 individuals with Tourette disorder, who underwent either thalamic (n = 15; centromedian/ventrooralis internus) or pallidal (n = 15; anterior segment of globus pallidus internus) deep brain stimulation and calculated whether connectivity between deep brain stimulation sites and the lesion network map could predict clinical improvements. Despite spatial heterogeneity, tic-inducing lesions mapped to a common network map, which comprised the insular cortices, cingulate gyrus, striatum, globus pallidus internus, thalami and cerebellum. Connectivity to a region within the anterior striatum (putamen) was specific to tic-inducing lesions when compared with control lesions. Connectivity between deep brain stimulation electrodes and the lesion network map was predictive of tic improvement, regardless of the deep brain stimulation target. Taken together, our results reveal a common brain network involved in tic generation, which shows potential as a therapeutic target for neuromodulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ganos, Christos UNSPECIFIED orcid.org/0000-0001-8077-8530 UNSPECIFIED Al-Fatly, Bassam UNSPECIFIED orcid.org/0000-0003-0067-6177 UNSPECIFIED Fischer, Jan-Frederik UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldermann, Juan-Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennen, Christina UNSPECIFIED orcid.org/0000-0003-2091-4638 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED orcid.org/0000-0002-5274-7929 UNSPECIFIED Neudorfer, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Martino, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED Bouwens, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ackermanns, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Leentjens, Albert F. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pyatigorskaya, Nadya UNSPECIFIED UNSPECIFIED UNSPECIFIED Worbe, Yulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fox, Michael D. UNSPECIFIED orcid.org/0000-0001-8848-6399 UNSPECIFIED Kuehn, Andrea A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Andreas UNSPECIFIED orcid.org/0000-0002-0695-6025 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695192
DOI:	10.1093/brain/awac009
Journal or Publication Title:	Brain
Volume:	145
Number:	12
Page Range:	S. 4385 - 4398
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2156
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LA-TOURETTE-SYNDROME; BASAL GANGLIA; DOUBLE-BLIND; STRUCTURAL-CHANGES; MOTOR TICS; CONNECTIVITY; LOCALIZATION; CORTEX; PATHOPHYSIOLOGY; ORGANIZATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69519