Universität zu Köln

Tamisier, Renaud ORCID: 0000-0003-1128-6529, Pepin, Jean-Louis, Cowie, Martin R., Wegscheider, Karl, Vettorazzi, Eik ORCID: 0000-0002-3737-6402, Suling, Anna, Angermann, Christiane, D'Ortho, Marie-Pia, Erdmann, Erland, Simonds, Anita K., Somers, Virend K., Teschler, Helmut, Levy, Patrick and Woehrle, Holger (2022). Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study. J. Sleep Res., 31 (6). HOBOKEN: WILEY. ISSN 1365-2869

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Abstract

This SERVE-HF (Treatment of Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure) sub study analysis evaluated polysomnography (PSG) data in patients with heart failure with reduced ejection fraction (HFrEF) and predominant central sleep apnea (CSA) randomised to guideline-based medical therapy, with or without adaptive servo ventilation (ASV). Patients underwent full overnight PSG at baseline and at 12 months. All PSG recordings were analysed by a core laboratory. Only data for patients with baseline and 3- or 12-month values were included. The sub study included 312 patients; the number with available PSG data differed for each variable (94-103 in the control group, 77-99 in the ASV group). After 12 months, baseline-adjusted respiratory measures were significantly better in the ASV group versus control. Although some between-group differences in sleep measures were seen at 12 months (e.g., better sleep efficiency in the ASV group), these were unlikely to be clinically significant. The number of periodic leg movements during sleep (PLMS) increased in the ASV group (p = 0.039). At 12 months, the respiratory arousal index was significantly lower in the ASV versus control group (p < 0.001), whilst the PLMS-related arousal index was significantly higher in the ASV group (p = 0.04 versus control). ASV attenuated the respiratory variables characterising sleep apnea in patients with HFrEF and predominant CSA in SERVE-HF. Sleep quality improvements during ASV therapy were small and unlikely to be clinically significant. The increase in PLMS and PLMS-related arousals during ASV warrants further investigation, particularly relating to their potential association with increased cardiovascular risk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tamisier, Renaud UNSPECIFIED orcid.org/0000-0003-1128-6529 UNSPECIFIED Pepin, Jean-Louis UNSPECIFIED UNSPECIFIED UNSPECIFIED Cowie, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegscheider, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Vettorazzi, Eik UNSPECIFIED orcid.org/0000-0002-3737-6402 UNSPECIFIED Suling, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Angermann, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Ortho, Marie-Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Simonds, Anita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Somers, Virend K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Levy, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehrle, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695283
DOI:	10.1111/jsr.13694
Journal or Publication Title:	J. Sleep Res.
Volume:	31
Number:	6
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2869
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITIVE AIRWAY PRESSURE; CHEYNE-STOKES RESPIRATION; PERIODIC LEG MOVEMENTS; LIMB MOVEMENTS; MORTALITY; SERVOVENTILATION; PREVALENCE; IMPACT; DURATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69528