Universität zu Köln

Whitfield, Tim ORCID: 0000-0002-0305-646X, Demnitz-King, Harriet, Schlosser, Marco ORCID: 0000-0002-0634-0749, Barnhofer, Thorsten, Frison, Eric ORCID: 0000-0001-5844-1886, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Dautricourt, Sophie, Requier, Florence, Delarue, Marion, Gonneaud, Julie ORCID: 0000-0003-0566-5581, Klimecki, Olga M., Lutz, Antoine, Paly, Leo, Salmon, Eric, Schild, Ann-Katrin ORCID: 0000-0002-1920-0198, Walker, Zuzana, Jessen, Frank, Chetelat, Gael, Collette, Fabienne, Wirth, Miranka and Marchant, Natalie L. (2022). Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial. Alzheimers Res. Ther., 14 (1). LONDON: BMC. ISSN 1758-9193

Full text not available from this repository.

Abstract

Background Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health self-management approaches) are a potential strategy to maintain or improve cognition in SCD, which may ultimately reduce dementia risk. Methods This study utilized data from the SCD-Well randomized controlled trial. One hundred forty-seven older adults with SCD (M-Age = 72.7 years; 64% female) were recruited from memory clinics in four European countries and randomized to one of two group-based, 8-week interventions: a Caring Mindfulness-based Approach for Seniors (CMBAS) or a health self-management program (HSMP). Participants were assessed at baseline, post-intervention (week 8), and at 6-month follow-up (week 24) using a range of cognitive tests. From these tests, three composites were derived-an abridged Preclinical Alzheimer's Cognitive Composite 5 (PACC5(Abridged)), an attention composite, and an executive function composite. Both per-protocol and intention-to-treat analyses were performed. Linear mixed models evaluated the change in outcomes between and within arms and adjusted for covariates and cognitive retest effects. Sensitivity models repeated the per-protocol analyses for participants who attended >= 4 intervention sessions. Results Across all cognitive composites, there were no significant time-by-trial arm interactions and no measurable cognitive retest effects; sensitivity analyses supported these results. Improvements, however, were observed within both trial arms on the PACC5(Abridged) from baseline to follow-up (Delta [95% confidence interval]: CMBAS = 0.34 [0.19, 0.48]; HSMP = 0.30 [0.15, 0.44]). There was weaker evidence of an improvement in attention but no effects on executive function. Conclusions Two non-pharmacological interventions conferred small, non-differing improvements to a global cognitive composite sensitive to amyloid-beta-related decline. There was weaker evidence of an effect on attention, and no evidence of an effect on executive function. Importantly, observed improvements were maintained beyond the end of the interventions. Improving cognition is an important step toward dementia prevention, and future research is needed to delineate the mechanisms of action of these interventions and to utilize clinical endpoints (i.e., progression to mild cognitive impairment or dementia).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Whitfield, Tim UNSPECIFIED orcid.org/0000-0002-0305-646X UNSPECIFIED Demnitz-King, Harriet UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlosser, Marco UNSPECIFIED orcid.org/0000-0002-0634-0749 UNSPECIFIED Barnhofer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Frison, Eric UNSPECIFIED orcid.org/0000-0001-5844-1886 UNSPECIFIED Coll-Padros, Nina UNSPECIFIED orcid.org/0000-0002-9282-6701 UNSPECIFIED Dautricourt, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Requier, Florence UNSPECIFIED UNSPECIFIED UNSPECIFIED Delarue, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Gonneaud, Julie UNSPECIFIED orcid.org/0000-0003-0566-5581 UNSPECIFIED Klimecki, Olga M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lutz, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Paly, Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Salmon, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Ann-Katrin UNSPECIFIED orcid.org/0000-0002-1920-0198 UNSPECIFIED Walker, Zuzana UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Chetelat, Gael UNSPECIFIED UNSPECIFIED UNSPECIFIED Collette, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Miranka UNSPECIFIED UNSPECIFIED UNSPECIFIED Marchant, Natalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695529
DOI:	10.1186/s13195-022-01057-w
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	14
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRESS REDUCTION; IMPAIRMENT; MEDITATION; COMPLAINTS; DEMENTIA; THERAPY; PROGRAM; IMPACT Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69552