Universität zu Köln

Vogt, Ferdinand ORCID: 0000-0002-1924-6823, Santarpino, Giuseppe ORCID: 0000-0002-4913-9834, Fujita, Buntaro ORCID: 0000-0002-3262-7727, Frerker, Christian, Bauer, Timm, Beckmann, Andreas, Bekeredjian, Raffi, Bleiziffer, Sabine ORCID: 0000-0001-9669-7372, Moellmann, Helge, Walther, Thomas, Beyersdorf, Friedhelm, Hamm, Christian, Boening, Andreas, Baldus, Stephan, Ensminger, Stephan, Fischlein, Theodor and Eckner, Dennis (2022). Surgical aortic valve replacement in patients aged 50-69 years-insights from the German Aortic Valve Registry (GARY). Eur. J. Cardio-Thorac. Surg., 62 (1). CARY: OXFORD UNIV PRESS INC. ISSN 1873-734X

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Abstract

OBJECTIVES: The aim of this study was to analyse the outcome of patients between 50 and 69 years of age undergoing biological or mechanical aortic valve replacement. METHODS: Data were collected from the German Aortic Valve Registry. Data were analysed regarding baseline characteristics and outcome parameters such as 5-year survival, stroke and reintervention. RESULTS: In tota1,3046 patients undergoing isolated surgical aortic valve replacement between 2011 and 2012 were investigated and a propensity score matching was performed. Within this period, 2239 patients received a biological prostheses, while 807 patients received a mechanical prosthesis. Mean age in the biological group was 63.07 (+/- 5.11) and 57.34 (+/- 4.67) in the mechanical group (standardized mean difference 1.172). In the overall cohort, there were more female patients in the biological group (32.7% vs 28.4%) and log EuroSCORE I was higher (5.41% vs 4.26%). After propensity matching (610 pairs), there was no difference in the mortality at 5-year followup (12.1% biological vs 9.2% mechanical P= 0.05) nor for reoperation/reintervention (2.5% biological vs 2.0% mechanical, P = 0.546). Patients undergoing mechanical aortic valve replacement suffered from a higher stroke rate 3.3% vs 1.5% (P= 0.04) at 5-year follow-up. CONCLUSIONS: Aortic valve replacement with biological or mechanical prostheses showed similar 5-year outcomes for survival and reoperation in a propensity-matched cohort, but significantly increased stroke rate after mechanical aortic valve replacement. This could influence the choice of a mechanical valve in younger patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vogt, Ferdinand UNSPECIFIED orcid.org/0000-0002-1924-6823 UNSPECIFIED Santarpino, Giuseppe UNSPECIFIED orcid.org/0000-0002-4913-9834 UNSPECIFIED Fujita, Buntaro UNSPECIFIED orcid.org/0000-0002-3262-7727 UNSPECIFIED Frerker, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Timm UNSPECIFIED UNSPECIFIED UNSPECIFIED Beckmann, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bekeredjian, Raffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Bleiziffer, Sabine UNSPECIFIED orcid.org/0000-0001-9669-7372 UNSPECIFIED Moellmann, Helge UNSPECIFIED UNSPECIFIED UNSPECIFIED Walther, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyersdorf, Friedhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamm, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Boening, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ensminger, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischlein, Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckner, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695606
DOI:	10.1093/ejcts/ezac286
Journal or Publication Title:	Eur. J. Cardio-Thorac. Surg.
Volume:	62
Number:	1
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1873-734X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OUTCOMES; SURGERY; PROSTHESES; SURVIVAL; SOCIETY; RISK Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69560