Heissig, Beate ORCID: 0000-0002-0348-5934, Salama, Yousef ORCID: 0000-0001-6254-6381, Iakoubov, Roman, Vehreschild, Joerg Janne, Rios, Ricardo ORCID: 0000-0003-1449-4745, Nogueira, Tatiane, Vehreschild, Maria J. G. T., Stecher, Melanie, Mori, Hirotake, Lanznaster, Julia, Adachi, Eisuke ORCID: 0000-0002-1623-873X, Jakob, Carolin, Tabe, Yoko, Ruethrich, Maria, Borgmann, Stefan, Naito, Toshio ORCID: 0000-0003-1646-9930, Wille, Kai ORCID: 0000-0002-7682-8563, Valenti, Simon, Hower, Martin ORCID: 0000-0001-5967-5238, Hattori, Nobutaka, Rieg, Siegbert, Nagaoka, Tetsutaro, Jensen, Bjoern-Erik, Yotsuyanagi, Hiroshi ORCID: 0000-0001-7882-5262, Hertenstein, Bernd, Ogawa, Hideoki, Wyen, Christoph, Kominami, Eiki, Roemmele, Christoph, Takahashi, Satoshi, Rupp, Jan ORCID: 0000-0001-8722-1233, Takahashi, Kazuhisa ORCID: 0000-0001-5749-4118, Hanses, Frank and Hattori, Koichi (2022). COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity. Biomedicines, 10 (10). BASEL: MDPI. ISSN 2227-9059

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Abstract

Although there is strong evidence that SARS-CoV-2 infection is associated with adverse outcomes in certain ethnic groups, the association of disease severity and risk factors such as comorbidities and biomarkers with racial disparities remains undefined. This retrospective study between March 2020 and February 2021 explores COVID-19 risk factors as predictors for patients' disease progression through country comparison. Disease severity predictors in Germany and Japan were cardiovascular-associated comorbidities, dementia, and age. We adjusted age, sex, body mass index, and history of cardiovascular disease comorbidity in the country cohorts using a propensity score matching (PSM) technique to reduce the influence of differences in sample size and the surprisingly young, lean Japanese cohort. Analysis of the 170 PSM pairs confirmed that 65.29% of German and 85.29% of Japanese patients were in the uncomplicated phase. More German than Japanese patients were admitted in the complicated and critical phase. Ethnic differences were identified in patients without cardiovascular comorbidities. Japanese patients in the uncomplicated phase presented a suppressed inflammatory response and coagulopathy with hypocoagulation. In contrast, German patients exhibited a hyperactive inflammatory response and coagulopathy with hypercoagulation. These differences were less pronounced in patients in the complicated phase or with cardiovascular diseases. Coagulation/fibrinolysis-associated biomarkers rather than inflammatory-related biomarkers predicted disease severity in patients with cardiovascular comorbidities: platelet counts were associated with severe illness in German patients. In contrast, high D-dimer and fibrinogen levels predicted disease severity in Japanese patients. Our comparative study indicates that ethnicity influences COVID-19-associated biomarker expression linked to the inflammatory and coagulation (thrombo-inflammatory) response. Future studies will be necessary to determine whether these differences contributed to the less severe disease progression observed in Japanese COVID-19 patients compared with those in Germany.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heissig, BeateUNSPECIFIEDorcid.org/0000-0002-0348-5934UNSPECIFIED
Salama, YousefUNSPECIFIEDorcid.org/0000-0001-6254-6381UNSPECIFIED
Iakoubov, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rios, RicardoUNSPECIFIEDorcid.org/0000-0003-1449-4745UNSPECIFIED
Nogueira, TatianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mori, HirotakeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lanznaster, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adachi, EisukeUNSPECIFIEDorcid.org/0000-0002-1623-873XUNSPECIFIED
Jakob, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabe, YokoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruethrich, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgmann, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naito, ToshioUNSPECIFIEDorcid.org/0000-0003-1646-9930UNSPECIFIED
Wille, KaiUNSPECIFIEDorcid.org/0000-0002-7682-8563UNSPECIFIED
Valenti, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hower, MartinUNSPECIFIEDorcid.org/0000-0001-5967-5238UNSPECIFIED
Hattori, NobutakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieg, SiegbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nagaoka, TetsutaroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, Bjoern-ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yotsuyanagi, HiroshiUNSPECIFIEDorcid.org/0000-0001-7882-5262UNSPECIFIED
Hertenstein, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ogawa, HideokiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kominami, EikiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roemmele, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takahashi, SatoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDorcid.org/0000-0001-8722-1233UNSPECIFIED
Takahashi, KazuhisaUNSPECIFIEDorcid.org/0000-0001-5749-4118UNSPECIFIED
Hanses, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hattori, KoichiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-695622
DOI: 10.3390/biomedicines10102549
Journal or Publication Title: Biomedicines
Volume: 10
Number: 10
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2227-9059
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DISEASE 2019 COVID-19; VENOUS THROMBOEMBOLISM; DISPARITIES; PNEUMONIA; JAPAN; CAREMultiple languages
Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69562

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