Universität zu Köln

Squarcina, Letizia, Kambeitz-Ilankovic, Lana ORCID: 0000-0002-8218-0425, Bonivento, Carolina, Prunas, Cecilia, Oldani, Lucio, Wenzel, Julian, Ruef, Anne, Dwyer, Dominic ORCID: 0000-0003-3949-5867, Ferro, Adele, Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Kambeitz, Joseph, Lichtenstein, Theresa Katharina ORCID: 0000-0001-5573-1212, Meisenzahl, Eva, Pantelis, Christos ORCID: 0000-0002-9565-0238, Rosen, Marlene, Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Antonucci, Linda A. ORCID: 0000-0002-7919-7402, Bertolino, Alessandro, Lencer, Rebekka, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Salokangas, Raimo R. K., Schultze-Lutter, Frauke, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Stainton, Alexandra, Wood, Stephen J., Koutsouleris, Nikolaos and Brambilla, Paolo (2022). Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression. World J. Biol. Psychiatry, 23 (8). S. 573 - 582. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412

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Abstract

Objective Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. Methods 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of the previous month and year, and a set of neurocognitive measures, were used for classification and regression. Results Neurocognitive measures related to GF-R at baseline (r = 0.20, p = 0.004), GF-S at present (r = 0.14, p = 0.042) and of the past year (r = 0.19, p = 0.005), for GAF-F of the past month (r = 0.24, p < 0.001) and GAF-D of the past year (r = 0.28, p = 0.002). Classification reached values of balanced accuracy of 61% for GF-R and GAF-D. Conclusion We found that neurocognition was related to psychosocial functioning. More specifically, a deficit in executive functions was associated to poor social and occupational functioning.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Squarcina, Letizia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED orcid.org/0000-0002-8218-0425 UNSPECIFIED Bonivento, Carolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Prunas, Cecilia UNSPECIFIED UNSPECIFIED UNSPECIFIED Oldani, Lucio UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruef, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Dwyer, Dominic UNSPECIFIED orcid.org/0000-0003-3949-5867 UNSPECIFIED Ferro, Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, Stefan UNSPECIFIED orcid.org/0000-0002-5792-3987 UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenstein, Theresa Katharina UNSPECIFIED orcid.org/0000-0001-5573-1212 UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantelis, Christos UNSPECIFIED orcid.org/0000-0002-9565-0238 UNSPECIFIED Rosen, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, Rachel UNSPECIFIED orcid.org/0000-0001-8204-5103 UNSPECIFIED Antonucci, Linda A. UNSPECIFIED orcid.org/0000-0002-7919-7402 UNSPECIFIED Bertolino, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Lencer, Rebekka UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Salokangas, Raimo R. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Chisholm, Katharine UNSPECIFIED orcid.org/0000-0002-0575-0789 UNSPECIFIED Stainton, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695745
DOI:	10.1080/15622975.2021.2014955
Journal or Publication Title:	World J. Biol. Psychiatry
Volume:	23
Number:	8
Page Range:	S. 573 - 582
Date:	2022
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1814-1412
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICAL HIGH-RISK; ULTRA-HIGH-RISK; FOLLOW-UP; 1ST-EPISODE PSYCHOSIS; INDIVIDUALS; PERFORMANCE; TRANSITION; SYMPTOMS; SAMPLE; NEUROCOGNITION Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69574