Universität zu Köln

Promislow, Daniel ORCID: 0000-0001-7088-4495, Anderson, Rozalyn M., Scheffer, Marten ORCID: 0000-0002-2100-0312, Crespi, Bernard, DeGregori, James ORCID: 0000-0002-1287-1976, Harris, Kelley, Horowitz, Barbara Natterson, Levine, Morgan E., Riolo, Maria A., Schneider, David S., Spencer, Sabrina L., Valenzano, Dario Riccardo and Hochberg, Michael E. (2022). Resilience integrates concepts in aging research. iScience, 25 (5). CAMBRIDGE: CELL PRESS. ISSN 2589-0042

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Abstract

Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Promislow, Daniel UNSPECIFIED orcid.org/0000-0001-7088-4495 UNSPECIFIED Anderson, Rozalyn M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheffer, Marten UNSPECIFIED orcid.org/0000-0002-2100-0312 UNSPECIFIED Crespi, Bernard UNSPECIFIED UNSPECIFIED UNSPECIFIED DeGregori, James UNSPECIFIED orcid.org/0000-0002-1287-1976 UNSPECIFIED Harris, Kelley UNSPECIFIED UNSPECIFIED UNSPECIFIED Horowitz, Barbara Natterson UNSPECIFIED UNSPECIFIED UNSPECIFIED Levine, Morgan E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riolo, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, David S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spencer, Sabrina L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Valenzano, Dario Riccardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hochberg, Michael E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-696072
DOI:	10.1016/j.isci.2022.104199
Journal or Publication Title:	iScience
Volume:	25
Number:	5
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2589-0042
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CALORIC RESTRICTION; GUT MICROBIOTA; LONGEVITY; DYSBIOSIS; BIOLOGY; EVOLUTION; VARIANCE; HORMESIS; DISEASE; STRESS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69607