Hoffmann, Christian, Jessen, Heiko, Wyen, Christoph, Grunwald, Stephan, Noe, Sebastian ORCID: 0000-0001-6863-3275, Teichmann, Joern, Krauss, Anja-Sophie, Kolarikal, Henning, Scholten, Stefan, Schuler, Christoph, Bickel, Markus, Roll, Clemens, Kreckel, Peter, Koeppe, Siegfried, Straub, Matthias, Klausen, Gerd, Lenz, Johannes, Esser, Stefan, Jensen, Bjoern, Rausch, Michael, Unger, Stefan, Pauli, Ramona, Haerter, Georg, Muller, Matthias, Masuhr, Anja, Schaefer, Guido, Seybold, Ulrich, Schellberg, Sven, Schneider, Jochen, Monin, Malte Benedikt, Wolf, Eva, Spinner, Christoph D. and Boesecke, Christoph . Clinical characteristics of monkeypox virus infections among men with and without HIV: A large outbreak cohort in Germany. HIV Med.. HOBOKEN: WILEY. ISSN 1468-1293

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Abstract

Background Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly from Africa, have suggested a higher risk for severe MPXV cases in people living with HIV. Methods This was a retrospective study of all confirmed MPXV infections observed in the participating centres since 19 May 2022. We conducted a chart review to evaluate clinical characteristics, comorbidities, and coinfections, including HIV, viral hepatitis, and sexually transmitted infections (STIs). Results By 30 June 2022, a total of 546 MPXV infections were reported from 42 German centres. All patients were men who have sex with men (MSM), of whom 256 (46.9%) were living with HIV, mostly with a preserved immune system and with viral suppression. In total, 232 (42.5%) MSM were also taking HIV pre-exposure prophylaxis (PrEP) and 58 (10.6%) MSM had no known HIV infection or PrEP use. The median age was 39 years (range 20-67), and comorbidities were rare. However, 52.4% and 29.4% of all patients had been diagnosed with at least one STI within the last 6 months or within the last 4 weeks, respectively. The most frequent localizations of MPXV infection were genital (49.9%) and anal (47.9%), whereas fever (53.2%) and lymphadenopathy (42.6%) were the most frequent general symptoms. The hospitalization rate was low (4.0%), and no fatal course was observed. The clinical picture showed no apparent differences between MSM with or without HIV. Conclusions In this preliminary cohort analysis from a current large outbreak among MSM in Germany, the clinical picture of MPXV infection did not differ between MSM with and without HIV infection. Severe courses were rare and hospitalization rates were low. However, most patients were relatively healthy, and only a few people living with HIV were viremic or severely immunosuppressed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hoffmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grunwald, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noe, SebastianUNSPECIFIEDorcid.org/0000-0001-6863-3275UNSPECIFIED
Teichmann, JoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krauss, Anja-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolarikal, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholten, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuler, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roll, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreckel, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koeppe, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Straub, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klausen, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenz, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esser, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rausch, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unger, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauli, RamonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haerter, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masuhr, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seybold, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schellberg, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monin, Malte BenediktUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spinner, Christoph D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boesecke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696109
DOI: 10.1111/hiv.13378
Journal or Publication Title: HIV Med.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1293
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SMALLPOX VACCINATION; IMMUNITYMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69610

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