Michels, Jennifer ORCID: 0000-0003-1782-8341, van der Wurp, Hendrick, Kalbe, Elke, Rehberg, Sarah Petra, Storch, Alexander, Linse, Katharina ORCID: 0000-0003-3086-7871, Schneider, Christine, Graeber, Susanne, Berg, Daniela ORCID: 0000-0001-5796-5442, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Ruediger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Gunther ORCID: 0000-0002-4176-9196, Mollenhauer, Brit, Trenkwalder, Claudia ORCID: 0000-0001-6407-1199, Liepelt-Scarfone, Inga, Spottke, Annika, Roeske, Sandra, Wuellner, Ullrich, Wittchen, Hans-Ulrich, Riedel, Oliver, Kassubek, Jan ORCID: 0000-0002-7106-9270, Dodel, Richard, Schulz, Joerg Bernhard, Costa, Ana Sofia ORCID: 0000-0002-1999-6616 and Reetz, Kathrin ORCID: 0000-0002-9730-9228 (2022). Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson's Disease. J. Parkinsons Dis., 12 (3). S. 905 - 917. AMSTERDAM: IOS PRESS. ISSN 1877-718X

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Abstract

Background: Parkinson's disease (PD) is associated with various non-motor symptoms, including cognitive deterioration. Objective: Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND). Methods: Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M= 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year followup data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M= 66.10; 68.6% males). Results: Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients was present and we found differences for motor phenotypes in attention (beta = -0.08, SE = 0.003, p < 0.006) and memory functions showing that PIGD-patients deteriorate per months by -0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living. Conclusion: Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Michels, JenniferUNSPECIFIEDorcid.org/0000-0003-1782-8341UNSPECIFIED
van der Wurp, HendrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rehberg, Sarah PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linse, KatharinaUNSPECIFIEDorcid.org/0000-0003-3086-7871UNSPECIFIED
Schneider, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeber, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDorcid.org/0000-0001-5796-5442UNSPECIFIED
Dams, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzer-Geldsetzer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker-Roggendorf, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberschmidt, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baudrexel, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, NeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuntherUNSPECIFIEDorcid.org/0000-0002-4176-9196UNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDorcid.org/0000-0001-6407-1199UNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuellner, UllrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Joerg BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Ana SofiaUNSPECIFIEDorcid.org/0000-0002-1999-6616UNSPECIFIED
Reetz, KathrinUNSPECIFIEDorcid.org/0000-0002-9730-9228UNSPECIFIED
URN: urn:nbn:de:hbz:38-696365
DOI: 10.3233/JPD-212787
Journal or Publication Title: J. Parkinsons Dis.
Volume: 12
Number: 3
Page Range: S. 905 - 917
Date: 2022
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1877-718X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEMENTIA; IMPAIRMENT; DEFICITS; SUBTYPEMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69636

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