Altomare, Daniele ORCID: 0000-0003-1905-8993, Collij, Lyduine, Caprioglio, Camilla, Scheltens, Philip, van Berckel, Bart N. M., Alves, Isadora Lopes, Berkhof, Johannes ORCID: 0000-0003-2094-2380, de Gier, Yvonne, Garibotto, Valentina ORCID: 0000-0003-2422-698X, Moro, Christian, Poitrine, Lea, Delrieu, Julien, Payoux, Pierre, Saint-Aubert, Laure, Luis Molinuevo, Jose, Grau-Rivera, Oriol, Gispert, Juan-Domingo, Minguillon, Carolina, Fauria, Karine, Felez Sanchez, Marta, Radoi, Andreea, Drzezga, Alexander, Jessen, Frank, Escher, Claus, Zeyen, Philip, Nordberg, Agneta, Savitcheva, Irina, Jelic, Vesna, Walker, Zuzana, Lee, Ho-Yun, Lee, Lean, Demonet, Jean-Francois, Wuthrich, Sonia Plaza, Gismondi, Rossella, Farrar, Gill, Barkhof, Frederik ORCID: 0000-0003-3543-3706, Stephens, Andrew W. and Frisoni, Giovanni B. ORCID: 0000-0002-6419-1753 . Description of a European memory clinic cohort undergoing amyloid-PET: The AMYPAD Diagnostic and Patient Management Study. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort. Methods Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice. Results A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms. Discussion The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Altomare, DanieleUNSPECIFIEDorcid.org/0000-0003-1905-8993UNSPECIFIED
Collij, LyduineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caprioglio, CamillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Berckel, Bart N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alves, Isadora LopesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkhof, JohannesUNSPECIFIEDorcid.org/0000-0003-2094-2380UNSPECIFIED
de Gier, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garibotto, ValentinaUNSPECIFIEDorcid.org/0000-0003-2422-698XUNSPECIFIED
Moro, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poitrine, LeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delrieu, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Payoux, PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saint-Aubert, LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luis Molinuevo, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grau-Rivera, OriolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gispert, Juan-DomingoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minguillon, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauria, KarineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felez Sanchez, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radoi, AndreeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Escher, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeyen, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordberg, AgnetaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Savitcheva, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jelic, VesnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, ZuzanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Ho-YunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, LeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demonet, Jean-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuthrich, Sonia PlazaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gismondi, RossellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farrar, GillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkhof, FrederikUNSPECIFIEDorcid.org/0000-0003-3543-3706UNSPECIFIED
Stephens, Andrew W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frisoni, Giovanni B.UNSPECIFIEDorcid.org/0000-0002-6419-1753UNSPECIFIED
URN: urn:nbn:de:hbz:38-696758
DOI: 10.1002/alz.12696
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; WORK-UP; DEMENTIA; DISEASE; RECOMMENDATIONS; GUIDELINESMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69675

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