Kunz, Wolfgang G., Sporns, Peter B., Psychogios, Marios N., Fiehler, Jens, Chapot, Rene, Dorn, Franziska, Grams, Astrid, Morotti, Andrea ORCID: 0000-0002-6558-1155, Musolino, Patricia, Lee, Sarah, Kemmling, Andre, Henkes, Hans, Nikoubashman, Omid, Wiesmann, Martin, Jensen-Kondering, Ulf, Moehlenbruch, Markus, Schlamann, Marc, Marik, Wolfgang, Schob, Stefan, Wendl, Christina, Turowski, Bernd, Goetz, Friedrich, Kaiser, Daniel ORCID: 0000-0001-5258-0025, Dimitriadis, Konstantinos, Gersing, Alexandra, Liebig, Thomas, Ricke, Jens, Reidler, Paul, Wildgruber, Moritz and Moench, Sebastian (2022). Cost-Effectiveness of Endovascular Thrombectomy in Childhood Stroke: An Analysis of the Save ChildS Study. J. Stroke, 24 (1). S. 138 - 148. SEOUL: KOREAN STROKE SOC. ISSN 2287-6405

Full text not available from this repository.

Abstract

Background and Purpose The Save ChildS Study demonstrated that endovascular thrombectomy (EVT) is a safe treatment option for pediatric stroke patients with large vessel occlusions (LVOs) with high recanalization rates. Our aim was to determine the long-term cost, health consequences and cost-effectiveness of EVT in this patient population. Methods In this retrospective study, a decision-analytic Markov model estimated lifetime costs and quality-adjusted life years (QALYs). Early outcome parameters were based on the entire Save ChildS Study to model the EVT group. As no randomized data exist, the Save ChildS patient sub-group with unsuccessful recanalization was used to model the standard of care group. For model -ing of lifetime estimates, pediatric and adult input parameters were obtained from the current lit- erature. The analysis was conducted in a United States setting applying healthcare and societal perspectives. Probabilistic sensitivity analyses were performed. The willingness-to-pay threshold was set to $100,000 per QALY. Results The model results yielded EVT as the dominant (cost-effective as well as cost-saving) strategy for pediatric stroke patients. The incremental effectiveness for the average age of 11.3 years at first stroke in the Save ChildS Study was determined as an additional 4.02 lifetime QALYs, with lifetime cost-savings that amounted to $169,982 from a healthcare perspective and $254,110 when applying a societal perspective. Acceptability rates for EVT were 96.60% and 96.66% for the healthcare and societal perspectives. Conclusions EVT for pediatric stroke patients with LVOs resulted in added QALY and reduced lifetime costs. Based on the available data in the Save ChildS Study, EVT is very likely to be a cost-effective treatment strategy for childhood stroke.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kunz, Wolfgang G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sporns, Peter B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Psychogios, Marios N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiehler, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chapot, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorn, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grams, AstridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morotti, AndreaUNSPECIFIEDorcid.org/0000-0002-6558-1155UNSPECIFIED
Musolino, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kemmling, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkes, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nikoubashman, OmidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen-Kondering, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehlenbruch, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlamann, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marik, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schob, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wendl, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turowski, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goetz, FriedrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, DanielUNSPECIFIEDorcid.org/0000-0001-5258-0025UNSPECIFIED
Dimitriadis, KonstantinosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gersing, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liebig, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ricke, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reidler, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wildgruber, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moench, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696802
DOI: 10.5853/jos.2021.01606
Journal or Publication Title: J. Stroke
Volume: 24
Number: 1
Page Range: S. 138 - 148
Date: 2022
Publisher: KOREAN STROKE SOC
Place of Publication: SEOUL
ISSN: 2287-6405
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACUTE ISCHEMIC-STROKE; QUALITY-OF-LIFE; RECURRENT STROKE; MECHANICAL THROMBECTOMY; PLASMINOGEN-ACTIVATOR; HOSPITAL COSTS; UNITED-STATES; RISK-FACTORS; CARE COSTS; POPULATIONMultiple languages
Clinical Neurology; Peripheral Vascular DiseaseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69680

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item