Universität zu Köln

Nardone, Olga Maria ORCID: 0000-0002-9554-4785, Bazarova, Alina, Bhandari, Pradeep, Cannatelli, Rosanna, Daperno, Marco, Ferraz, Jose, Goetz, Martin, Gui, Xianyong, Hayee, Bu, De Hertogh, Gert, Lazarev, Mark, Li, Ji, Parra-Blanco, Adolfo, Pastorelli, Luca ORCID: 0000-0002-2810-9951, Panaccione, Remo, Occhipinti, Vincenzo, Rath, Timo ORCID: 0000-0002-7728-9338, Smith, Samuel C. L., Shivaji, Uday N., Tontini, Gian Eugenio, Vieth, Michael, Villanacci, Vincenzo, Zardo, Davide, Bisschops, Raf ORCID: 0000-0002-9994-8226, Kiesslich, Ralf, Ghosh, Subrata and Iacucci, Marietta (2022). Endoscopic remission assessed with PICaSSO virtual electronic chromendoscopy accurately predicts clinical outcomes in ulcerative colitis. United European Gastroenterol. J., 10 (2). S. 147 - 160. CHICHESTER: JOHN WILEY & SONS LTD. ISSN 2050-6414

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Abstract

Background and Aims A composite endoscopic-histologic remission is increasingly explored as an important endpoint in ulcerative colitis (UC). We investigated combined endoscopic-histologic remission for predicting clinical outcomes at 12 months compared with endoscopic remission alone using the high definition virtual chromoendoscopy (VCE) Paddington International virtual ChromoendoScopy ScOre (PICaSSO) and histology scores. Methods Ulcerative colitis patients, prospectively enrolled from 11 international centres, underwent VCE with targeted biopsies and followed up for 12 months. Endoscopic activity was assessed by Mayo Endoscopic Score (MES), Ulcerative Colitis Endoscopic Index Severity (UCEIS) followed by VCE-PICaSSO. Robarts Histopathological Index|Robarts Histological index <= 3 without neutrophils in mucosa, and Nancy Histological index (NHI)<= 1 were used to define histologic remission. Combined endoscopic-histologic remission was compared with endoscopic remission alone by Cox proportional hazards model and by two- and three-proportion analysis using pre-specified clinical outcomes. Results 307 patients were recruited and 302 analysed. There was no difference in survival without specified clinical outcomes between PICaSSO defined endoscopic remission alone and endoscopic plus histologic remission in the rectum (HR 0.42, 95%CI 0.16-1.11 and HR 1.03, 95%CI 0.42-2.52 for Robarts Histological index and NHI respectively) at 12 months. There was however a significant survival advantage without specified clinical outcome events for UCEIS combined with histology compared with UCEIS alone (HR 0.30, 95%CI 0.12-0.75, p = 0.02) at 12 months (but not combined with NHI). For MES there was no advantage for predicting specified clinical outcomes at 12 months for endoscopy alone versus endoscopy plus histology, but there were differences in two and three proportion analysis at 6 months. Conclusion Endoscopic remission by VCE-PICaSSO alone was similar to combined endoscopic and histologic remission for predicting specified clinical outcomes at 12 months. Larger studies with specific therapeutic interventions are required to further confirm the findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nardone, Olga Maria UNSPECIFIED orcid.org/0000-0002-9554-4785 UNSPECIFIED Bazarova, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhandari, Pradeep UNSPECIFIED UNSPECIFIED UNSPECIFIED Cannatelli, Rosanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Daperno, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferraz, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Goetz, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Gui, Xianyong UNSPECIFIED UNSPECIFIED UNSPECIFIED Hayee, Bu UNSPECIFIED UNSPECIFIED UNSPECIFIED De Hertogh, Gert UNSPECIFIED UNSPECIFIED UNSPECIFIED Lazarev, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Ji UNSPECIFIED UNSPECIFIED UNSPECIFIED Parra-Blanco, Adolfo UNSPECIFIED UNSPECIFIED UNSPECIFIED Pastorelli, Luca UNSPECIFIED orcid.org/0000-0002-2810-9951 UNSPECIFIED Panaccione, Remo UNSPECIFIED UNSPECIFIED UNSPECIFIED Occhipinti, Vincenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Rath, Timo UNSPECIFIED orcid.org/0000-0002-7728-9338 UNSPECIFIED Smith, Samuel C. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shivaji, Uday N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tontini, Gian Eugenio UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieth, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Villanacci, Vincenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Zardo, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Bisschops, Raf UNSPECIFIED orcid.org/0000-0002-9994-8226 UNSPECIFIED Kiesslich, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghosh, Subrata UNSPECIFIED UNSPECIFIED UNSPECIFIED Iacucci, Marietta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-696883
DOI:	10.1002/ueg2.12185
Journal or Publication Title:	United European Gastroenterol. J.
Volume:	10
Number:	2
Page Range:	S. 147 - 160
Date:	2022
Publisher:	JOHN WILEY & SONS LTD
Place of Publication:	CHICHESTER
ISSN:	2050-6414
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HISTOLOGICAL DISEASE-ACTIVITY; CHROMOENDOSCOPY SCORE; NORMALIZATION OCCURS; RELAPSE; COLONOSCOPY; PATCHINESS; THERAPY; RISK Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69688