Bruch, Peter-Martin ORCID: 0000-0002-9992-3109, Dietrich, Sascha ORCID: 0000-0002-0648-1832, Finel, Herve, Boumendil, Ariane, Greinix, Hildegard ORCID: 0000-0002-2780-3300, Heinicke, Thomas ORCID: 0000-0002-4049-7854, Bethge, Wolfgang ORCID: 0000-0001-6052-2618, Beelen, Dietrich ORCID: 0000-0001-5050-220X, Schmid, Christoph ORCID: 0000-0001-7070-487X, Martin, Hans, Castagna, Luca, Scheid, Christof, Schaefer-Eckart, Kerstin, Bittenbring, Joerg, Finke, Juergen, Sengeloev, Henrik, Heiblig, Mael, Cornelissen, Jan, Chevallier, Patrice, Mohty, Mohamad, Robinson, Stephen, Montoto, Silvia and Dreger, Peter . Retrospective analysis of hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: conditioning intensity matters. Leukemia. LONDON: SPRINGERNATURE. ISSN 1476-5551

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Abstract

Blastic plasmacytoid dendritic cell neoplasia (BPDCN) is a rare myeloid malignancy with a generally poor prognosis. Although preliminary evidence suggests that hematopoietic cell transplantation (HCT) could improve outcome in patients with BPDCN, the individual contributions of conditioning and graft-versus-tumor (GVT) effects to HCT success are undefined. We present a retrospective study of 162 adult patients who underwent a first HCT (allogeneic 146, autologous 16) between 2009 and 2017, and were registered with the EBMT. Median age was 57 (range 20-73) years, and disease status at HCT was first complete remission (CR1) in 78%. Among patients receiving allogeneic HCT (alloHCT), myeloablative conditioning (MAC), reduced intensity conditioning (RIC) and in-vivo T-cell depletion (TCD) were used in 54%, 46%, and 59% respectively. Total body irradiation (TBI) was the conditioning backbone in 61% of MAC and 26% of RIC transplants. One-year overall survival (OS) and progression-free survival (PFS) rates were comparable after alloHCT and autologous HCT (autoHCT). Among alloHCT recipients, MAC with TBI significantly improved OS and PFS, independently of CR1, age, Karnofsky index and TCD. Accordingly, MAC (ideally based on TBI) should be preferred for alloHCT recipients with BPDCN. In patients who are not elegible for MAC alloHCT, autoHCT could be considered.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bruch, Peter-MartinUNSPECIFIEDorcid.org/0000-0002-9992-3109UNSPECIFIED
Dietrich, SaschaUNSPECIFIEDorcid.org/0000-0002-0648-1832UNSPECIFIED
Finel, HerveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boumendil, ArianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greinix, HildegardUNSPECIFIEDorcid.org/0000-0002-2780-3300UNSPECIFIED
Heinicke, ThomasUNSPECIFIEDorcid.org/0000-0002-4049-7854UNSPECIFIED
Bethge, WolfgangUNSPECIFIEDorcid.org/0000-0001-6052-2618UNSPECIFIED
Beelen, DietrichUNSPECIFIEDorcid.org/0000-0001-5050-220XUNSPECIFIED
Schmid, ChristophUNSPECIFIEDorcid.org/0000-0001-7070-487XUNSPECIFIED
Martin, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagna, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer-Eckart, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bittenbring, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finke, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sengeloev, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiblig, MaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelissen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chevallier, PatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohty, MohamadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robinson, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montoto, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreger, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697396
DOI: 10.1038/s41375-022-01782-z
Journal or Publication Title: Leukemia
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5551
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69739

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