Universität zu Köln

Penzel, Nora ORCID: 0000-0003-1624-386X, Sanfelici, Rachele, Antonucci, Linda A. ORCID: 0000-0002-7919-7402, Betz, Linda T. ORCID: 0000-0003-1741-4069, Dwyer, Dominic ORCID: 0000-0003-3949-5867, Ruef, Anne, Cho, Kang Ik K., Cumming, Paul, Pogarell, Oliver, Howes, Oliver ORCID: 0000-0002-2928-1972, Falkai, Peter, Upthegrove, Rachel, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Schultze-Lutter, Frauke, Rosen, Marlene, Lichtenstein, Theresa, Kambeitz-Ilankovic, Lana ORCID: 0000-0002-8218-0425, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Salokangas, Raimo K. R., Pantelis, Christos ORCID: 0000-0002-9565-0238, Wood, Stephen J., Quednow, Boris B. ORCID: 0000-0001-7933-2865, Pergola, Giulio, Bertolino, Alessandro, Koutsouleris, Nikolaos and Kambeitz, Joseph (2022). Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis. Schizophr., 8 (1). BERLIN: NATURE PORTFOLIO. ISSN 2754-6993

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Abstract

Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients, but no generalizable model has hitherto been tested for its ability to predict CCu in these vulnerable patient groups. In the current study, we investigated how structured clinical and cognitive assessments and structural magnetic resonance imaging (sMRI) contributed to the prediction of CCu in a group of 109 patients with recent-onset psychosis (ROP). We tested the generalizability of our predictors in 73 patients at clinical high-risk for psychosis (CHR). Here, CCu was defined as any cannabis consumption between baseline and 9-month follow-up, as assessed in structured interviews. All patients reported lifetime cannabis use at baseline. Data from clinical assessment alone correctly classified 73% (p < 0.001) of ROP and 59 % of CHR patients. The classifications of CCu based on sMRI and cognition were non-significant (ps > 0.093), and their addition to the interview-based predictor via stacking did not improve prediction significantly, either in the ROP or CHR groups (ps > 0.065). Lower functioning, specific substance use patterns, urbanicity and a lack of other coping strategies contributed reliably to the prediction of CCu and might thus represent important factors for guiding preventative efforts. Our results suggest that it may be possible to identify by clinical measures those psychosis-spectrum patients at high risk for CCu, potentially allowing to improve clinical care through targeted interventions. However, our model needs further testing in larger samples including more diverse clinical populations before being transferred into clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Penzel, Nora UNSPECIFIED orcid.org/0000-0003-1624-386X UNSPECIFIED Sanfelici, Rachele UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonucci, Linda A. UNSPECIFIED orcid.org/0000-0002-7919-7402 UNSPECIFIED Betz, Linda T. UNSPECIFIED orcid.org/0000-0003-1741-4069 UNSPECIFIED Dwyer, Dominic UNSPECIFIED orcid.org/0000-0003-3949-5867 UNSPECIFIED Ruef, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Cho, Kang Ik K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cumming, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Pogarell, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Howes, Oliver UNSPECIFIED orcid.org/0000-0002-2928-1972 UNSPECIFIED Falkai, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, Rachel UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Lencer, Rebekka UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisenzahl, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenstein, Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, Lana UNSPECIFIED orcid.org/0000-0002-8218-0425 UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Salokangas, Raimo K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantelis, Christos UNSPECIFIED orcid.org/0000-0002-9565-0238 UNSPECIFIED Wood, Stephen J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quednow, Boris B. UNSPECIFIED orcid.org/0000-0001-7933-2865 UNSPECIFIED Pergola, Giulio UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertolino, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-697676
DOI:	10.1038/s41537-022-00218-y
Journal or Publication Title:	Schizophr.
Volume:	8
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2754-6993
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 1ST-EPISODE PSYCHOSIS; CORTICAL THICKNESS; TREATMENT OUTCOMES; GLOBAL ASSESSMENT; BRAIN STRUCTURE; RELAPSE; ALCOHOL; SCHIZOPHRENIA; DEPENDENCE; MODELS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69767