Kohl, Stefan, Avni, Fred E., Boor, Peter, Capone, Valentina, Clapp, William L., De Palma, Diego, Harris, Tess, Heidet, Laurence, Hilger, Alina C., Liapis, Helen, Lilien, Marc, Manzoni, Gianantonio, Montini, Giovanni, Negrisolo, Susanna ORCID: 0000-0002-2229-1502, Pierrat, Marie-Jeanne, Raes, Ann ORCID: 0000-0001-7809-2505, Reutter, Heiko, Schreuder, Michiel F., Weber, Stefanie, Winyard, Paul J. D., Woolf, Adrian S., Schaefer, Franz and Liebau, Max C. (2022). Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations. Nephrol. Dial. Transplant., 37 (12). S. 2351 - 2363. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2385

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Abstract

Kidney dysplasia is one of the most frequent causes of chronic kidney failure in children. While dysplasia is a histological diagnosis, the term 'kidney dysplasia' is frequently used in daily clinical life without histopathological confirmation. Clinical parameters of kidney dysplasia have not been clearly defined, leading to imprecise communication amongst healthcare professionals and patients. This lack of consensus hampers precise disease understanding and the development of specific therapies. Based on a structured literature search, we here suggest a common basis for clinical, imaging, genetic, pathological and basic science aspects of non-obstructive kidney dysplasia associated with functional kidney impairment. We propose to accept hallmark sonographic findings as surrogate parameters defining a clinical diagnosis of dysplastic kidneys. We suggest differentiated clinical follow-up plans for children with kidney dysplasia and summarize established monogenic causes for non-obstructive kidney dysplasia. Finally, we point out and discuss research gaps in the field.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kohl, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avni, Fred E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boor, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Capone, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clapp, William L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Palma, DiegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harris, TessUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heidet, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilger, Alina C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liapis, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lilien, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manzoni, GianantonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montini, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Negrisolo, SusannaUNSPECIFIEDorcid.org/0000-0002-2229-1502UNSPECIFIED
Pierrat, Marie-JeanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raes, AnnUNSPECIFIEDorcid.org/0000-0001-7809-2505UNSPECIFIED
Reutter, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreuder, Michiel F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winyard, Paul J. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woolf, Adrian S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liebau, Max C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698072
DOI: 10.1093/ndt/gfac207
Journal or Publication Title: Nephrol. Dial. Transplant.
Volume: 37
Number: 12
Page Range: S. 2351 - 2363
Date: 2022
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2385
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CONGENITAL-ANOMALIES; URINARY-TRACT; RENAL DYSPLASIA; RISK-FACTORS; CHILDREN; MUTATIONS; DISEASE; GUIDELINES; GENES; ASSOCIATIONMultiple languages
Transplantation; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69807

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