Universität zu Köln

Terbuch, Angelika, Posch, Florian, Bauernhofer, Thomas, Jost, Philipp J. ORCID: 0000-0003-2454-0362, Partl, Richard, Stranzl-Lawatsch, Heidi, Baciarello, Giulia, Fizazi, Karim, Giannatempo, Patrizia, Verzoni, Elena, Sweeney, Christopher, Ravi, Praful, Tran, Ben, Basso, Umberto, White, Jeff, Vincenzi, Bruno, Oing, Christoph, Cutuli, Hernan Javier, Dieckmann, Klaus Peter, Gamulin, Marija, Chovanec, Michal, Fankhauser, Christian Daniel, Heidenreich, Axel, Mohamad, Osama, Thibault, Constance, Fischer, Stefanie and Gillessen, Silke (2022). Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. Int. J. Radiat. Oncol. Biol. Phys., 113 (4). S. 825 - 833. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-355X

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Abstract

Purpose: Radiation therapy is a possible treatment strategy for patients with testicular seminoma after orchiectomy in clinical stage I or II disease. Little is known about the outcome of patients who experience a relapse after radiation therapy. Methods and Materials: Data from 61 patients who relapsed after adjuvant or curative radiation therapy from 17 centers in 11 countries were collected and retrospectively analyzed. Primary outcomes were disease-free and overall survival. Secondary outcomes were time to relapse, stage at relapse, treatment for relapse, and rate of febrile neutropenia during chemotherapy for relapse. Results: With a median follow-up of 9.9 years (95% confidence interval [CI], 7.5-10.9), we found a 5-year disease-free survival of 90% (95% CI, 79-95) and a 5-year overall survival of 98% (95% CI, 89-100). Sixty-six percent of patients had stage III disease at time of relapse and 93% of patients fell into the good prognosis group per the International Germ Cell Cancer Collaborative Group classification. The median time to relapse after radiation therapy was 15.6 months (95% CI, 12-23). Twenty-two (36%) patients relapsed more than 2 years after radiation therapy and 7 (11.5%) patients relapsed more than 5 years after radiation therapy. One-third of relapses was detected owing to patients' symptoms, whereas two-thirds of relapses were detected during routine follow-up. The majority (93%) of cases were treated with cisplatin-based chemotherapy. The rate of febrile neutropenia during chemotherapy was 35%. Five patients experienced a second relapse. At last follow-up, 55 patients (90%) were alive without disease. Only 1 patient died owing to disease progression. Conclusions: Cisplatin-based chemotherapy for patients with seminoma who have relapsed after treatment with radiation therapy alone leads to excellent outcomes. Patients and physicians should be aware of possible late relapses after radiation therapy. (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Terbuch, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED Posch, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauernhofer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Jost, Philipp J. UNSPECIFIED orcid.org/0000-0003-2454-0362 UNSPECIFIED Partl, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Stranzl-Lawatsch, Heidi UNSPECIFIED UNSPECIFIED UNSPECIFIED Baciarello, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fizazi, Karim UNSPECIFIED UNSPECIFIED UNSPECIFIED Giannatempo, Patrizia UNSPECIFIED UNSPECIFIED UNSPECIFIED Verzoni, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Sweeney, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Ravi, Praful UNSPECIFIED UNSPECIFIED UNSPECIFIED Tran, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Basso, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED White, Jeff UNSPECIFIED UNSPECIFIED UNSPECIFIED Vincenzi, Bruno UNSPECIFIED UNSPECIFIED UNSPECIFIED Oing, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Cutuli, Hernan Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Dieckmann, Klaus Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gamulin, Marija UNSPECIFIED UNSPECIFIED UNSPECIFIED Chovanec, Michal UNSPECIFIED UNSPECIFIED UNSPECIFIED Fankhauser, Christian Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohamad, Osama UNSPECIFIED UNSPECIFIED UNSPECIFIED Thibault, Constance UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillessen, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-698260
DOI:	10.1016/j.ijrobp.2022.03.021
Journal or Publication Title:	Int. J. Radiat. Oncol. Biol. Phys.
Volume:	113
Number:	4
Page Range:	S. 825 - 833
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-355X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERM-CELL CANCER; STAGE-I SEMINOMA; FEBRILE NEUTROPENIA; RADIOTHERAPY; CARBOPLATIN; CHEMOTHERAPY; SURVIVAL; SURVEILLANCE; RECURRENCE; TOXICITY Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69826