Wild, Mirjam G., Kreidel, Felix, Hell, Michaela M., Praz, Fabien, Mach, Markus ORCID: 0000-0002-3184-4914, Adam, Matti, Reineke, David, Ruge, Hendrik ORCID: 0000-0001-6886-3660, Ludwig, Sebastian ORCID: 0000-0002-5752-4951, Conradi, Lenard, Rudolph, Tanja K., Bleiziffer, Sabine, Kellermair, Joerg, Zierer, Andreas ORCID: 0000-0002-9842-587X, Nickenig, Georg, Weber, Marcel, Petronio, Anna Sonia, Giannini, Cristina, Dahle, Gry, Rein, Kjell A., Coisne, Augustin ORCID: 0000-0002-1662-7874, Vincentelli, Andre, Dubois, Christophe, Duncan, Alison, Quarto, Cesare, Unbehaun, Axel, Amat-Santos, Ignacio, Cobiella, Javier, Dumonteil, Nicolas, Estevez-Loureiro, Rodrigo ORCID: 0000-0001-5841-5514, Fumero, Andrea, Geisler, Tobias, Lurz, Philipp, Mangieri, Antonio, Monivas, Vanessa, Noack, Thilo, Franco, Luis Nombela, Pinon, Miguel A., Stolz, Lukas, Tchetche, Didier, Walter, Thomas, Unsoeld, Bernhard, Baldus, Stephan, Andreas, Martin ORCID: 0000-0003-4950-5432, Hausleiter, Joerg and von Bardeleben, Ralph S. (2022). Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience. Eur. J. Heart Fail., 24 (5). S. 899 - 908. HOBOKEN: WILEY. ISSN 1879-0844

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Abstract

Aims Transcatheter mitral valve implantation (TMVI) is a new treatment option for patients with symptomatic mitral valve (MV) disease. Real-world data have not yet been reported. This study aimed to assess procedural and 30-day outcomes of TMVI in a real-world patient cohort. Method and results All consecutive patients undergoing implantation of a transapically delivered self-expanding valve at 26 European centres from January 2020 to April 2021 were included in this retrospective observational registry. Among 108 surgical high-risk patients included (43% female, mean age 75 +/- 7 years, mean STS-PROM 7.2 +/- 5.3%), 25% was treated for an off-label indication (e.g. previous MV intervention or surgery, mitral stenosis, mitral annular calcification). Patients were highly symptomatic (New York Heart Association [NYHA] functional class III/IV in 86%) and mitral regurgitation (MR) was graded 3+/4+ in 95% (38% primary, 37% secondary, and 25% mixed aetiology). Technical success rate was 96%, and MR reduction to <= 1+ was achieved in all patients with successful implantation. There were two procedural deaths and 30-day all-cause mortality was 12%. At early clinical follow-up, MR reduction was sustained and there were significant reductions of pulmonary pressure (systolic pulmonary artery pressure 52 vs. 42 mmHg, p < 0.001), and tricuspid regurgitation severity (p = 0.013). Heart failure symptoms improved significantly (73% in NYHA class I/II, p < 0.001). Procedural success rate according to MVARC criteria was 80% and was not different in patients treated for an off-label indication (74% vs. 81% for off- vs. on-label, p = 0.41). Conclusion In a real-world patient population, TMVI has a high technical and procedural success rate with efficient and durable MR reduction and symptomatic improvement.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wild, Mirjam G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreidel, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hell, Michaela M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Praz, FabienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mach, MarkusUNSPECIFIEDorcid.org/0000-0002-3184-4914UNSPECIFIED
Adam, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reineke, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, HendrikUNSPECIFIEDorcid.org/0000-0001-6886-3660UNSPECIFIED
Ludwig, SebastianUNSPECIFIEDorcid.org/0000-0002-5752-4951UNSPECIFIED
Conradi, LenardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudolph, Tanja K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bleiziffer, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kellermair, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zierer, AndreasUNSPECIFIEDorcid.org/0000-0002-9842-587XUNSPECIFIED
Nickenig, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petronio, Anna SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giannini, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahle, GryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rein, Kjell A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coisne, AugustinUNSPECIFIEDorcid.org/0000-0002-1662-7874UNSPECIFIED
Vincentelli, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, ChristopheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duncan, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quarto, CesareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unbehaun, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amat-Santos, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cobiella, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumonteil, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Estevez-Loureiro, RodrigoUNSPECIFIEDorcid.org/0000-0001-5841-5514UNSPECIFIED
Fumero, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geisler, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lurz, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangieri, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monivas, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noack, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franco, Luis NombelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinon, Miguel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stolz, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tchetche, DidierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unsoeld, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreas, MartinUNSPECIFIEDorcid.org/0000-0003-4950-5432UNSPECIFIED
Hausleiter, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bardeleben, Ralph S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698333
DOI: 10.1002/ejhf.2434
Journal or Publication Title: Eur. J. Heart Fail.
Volume: 24
Number: 5
Page Range: S. 899 - 908
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1879-0844
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REPAIR; REGURGITATION; REPLACEMENT; OUTCOMES; FEASIBILITY; PROSTHESISMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69833

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