Hoang-Xuan, Khe, Deckert, Martina, Ferreri, Andres J. M., Furtner, Julia, Perez-Larraya, Jaime Gallego, Henriksson, Roger, Hottinger, Andreas F., Kasenda, Benjamin ORCID: 0000-0003-0110-8585, Lefranc, Florence, Lossos, Alexander, McBain, Catherine, Preusser, Matthias, Roth, Patrick, Ruda, Roberta, Schlegel, Uwe, Soffietti, Riccardo, Soussain, Carole, Taphoorn, Martin J. B., Touitou, Valerie, Weller, Michael ORCID: 0000-0002-1748-174X and Bromberg, Jacoline E. C. (2023). European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL). Neuro-Oncology, 25 (1). S. 37 - 54. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the limited number of controlled studies available. In 2021, given recent advances and the publication of practice-changing randomized trials, the European Association of Neuro-Oncology (EANO) created a multidisciplinary task force to update the previously published evidence-based guidelines for immunocompetent adult patients with PCNSL and added a section on immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly. The main changes from the previous guideline include strengthened evidence for the consolidation with ASCT in first-line treatment, prospectively assessed chemotherapy combinations for both young and elderly patients, clarification of the role of rituximab even though the data remain inconclusive, of the role of new agents, and the incorporation of immunosuppressed patients and primary ocular lymphoma. The guideline should aid the clinicians in everyday practice and decision making and serve as a basis for future research in the field.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hoang-Xuan, KheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deckert, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferreri, Andres J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Furtner, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Larraya, Jaime GallegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henriksson, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hottinger, Andreas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasenda, BenjaminUNSPECIFIEDorcid.org/0000-0003-0110-8585UNSPECIFIED
Lefranc, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lossos, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McBain, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preusser, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruda, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlegel, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soffietti, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soussain, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taphoorn, Martin J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Touitou, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
Bromberg, Jacoline E. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698394
DOI: 10.1093/neuonc/noac196
Journal or Publication Title: Neuro-Oncology
Volume: 25
Number: 1
Page Range: S. 37 - 54
Date: 2023
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1523-5866
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; WHOLE-BRAIN RADIOTHERAPY; RECURRENT PRIMARY CNS; STEM-CELL RESCUE; QUALITY-OF-LIFE; TERM-FOLLOW-UP; PRIMARY VITREORETINAL LYMPHOMA; PRIMARY INTRAOCULAR LYMPHOMA; NON-HODGKINS-LYMPHOMAMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69839

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