Ben Ali, Walid, Ludwig, Sebastian ORCID: 0000-0002-5752-4951, Duncan, Alison, Weimann, Jessica, Nickenig, Georg, Tanaka, Tetsu ORCID: 0000-0003-0780-8689, Coisne, Augustin ORCID: 0000-0002-1662-7874, Vincentelli, Andre, Makkar, Raj, Webb, John G., Akodad, Mariama, Muller, David W. M., Praz, Fabien, Wild, Mirjam G., Hausleiter, Joerg, Goel, Sachin S., von Ballmoos, Moritz Wyler, Denti, Paolo ORCID: 0000-0002-3075-0203, Chehab, Omar, Redwood, Simon, Dahle, Gry, Baldus, Stephan, Adam, Matti, Ruge, Hendrik, Lange, Rudiger, Kaneko, Tsuyoshi, Leroux, Lionel, Dumonteil, Nicolas, Tchetche, Didier, Treede, Hendrik, Flagiello, Michele, Obadia, Jean-Francois, Walther, Thomas, Taramasso, Maurizio, Sondergaard, Lars, Bleiziffer, Sabine, Rudolph, Tanja K., Fam, Neil, Kempfert, Joerg, Granada, Juan F., Tang, Gilbert H. L., von Bardeleben, Ralph Stephan, Conradi, Lenard and Modine, Thomas (2022). Characteristics and outcomes of patients screened for transcatheter mitral valve implantation: 1-year results from the CHOICE-MI registry. Eur. J. Heart Fail., 24 (5). S. 887 - 899. HOBOKEN: WILEY. ISSN 1879-0844

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Abstract

Aims Transcatheter mitral valve implantation (TMVI) represents a novel treatment option for patients with mitral regurgitation (MR) unsuitable for established therapies. The CHOICE-MI registry aimed to investigate outcomes of patients undergoing screening for TMVI. Methods and results From May 2014 to March 2021, patients with MR considered suboptimal candidates for transcatheter edge-to-edge repair (TEER) and at high risk for mitral valve surgery underwent TMVI screening at 26 centres. Characteristics and outcomes were investigated for patients undergoing TMVI and for TMVI-ineligible patients referred to bailout-TEER, high-risk surgery or medical therapy (MT). The primary composite endpoint was all-cause mortality or heart failure hospitalization after 1 year. Among 746 patients included (78.5 years, interquartile range [IQR] 72.0-83.0, EuroSCORE II 4.7% [IQR 2.7-9.7]), 229 patients (30.7%) underwent TMVI with 10 different dedicated devices. At 1 year, residual MR <= 1+ was present in 95.2% and the primary endpoint occurred in 39.2% of patients treated with TMVI. In TMVI-ineligible patients (n = 517, 69.3%), rates of residual MR <= 1+ were 37.2%, 100.0% and 2.4% after bailout-TEER, high-risk surgery and MT, respectively. The primary endpoint at 1 year occurred in 28.8% of patients referred to bailout-TEER, in 42.9% of patients undergoing high-risk surgery and in 47.9% of patients remaining on MT. Conclusion This registry included the largest number of patients treated with TMVI to date. TMVI with 10 dedicated devices resulted in predictable MR elimination and sustained functional improvement at 1 year. In TMVI-ineligible patients, bailout-TEER and high-risk surgery represented reasonable alternatives, while MT was associated with poor clinical and functional outcomes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ben Ali, WalidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ludwig, SebastianUNSPECIFIEDorcid.org/0000-0002-5752-4951UNSPECIFIED
Duncan, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weimann, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickenig, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tanaka, TetsuUNSPECIFIEDorcid.org/0000-0003-0780-8689UNSPECIFIED
Coisne, AugustinUNSPECIFIEDorcid.org/0000-0002-1662-7874UNSPECIFIED
Vincentelli, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makkar, RajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Webb, John G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akodad, MariamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, David W. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Praz, FabienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wild, Mirjam G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hausleiter, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goel, Sachin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Ballmoos, Moritz WylerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denti, PaoloUNSPECIFIEDorcid.org/0000-0002-3075-0203UNSPECIFIED
Chehab, OmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Redwood, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahle, GryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adam, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, RudigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaneko, TsuyoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leroux, LionelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumonteil, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tchetche, DidierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treede, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flagiello, MicheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obadia, Jean-FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walther, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taramasso, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sondergaard, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bleiziffer, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudolph, Tanja K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fam, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kempfert, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Granada, Juan F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tang, Gilbert H. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bardeleben, Ralph StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conradi, LenardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Modine, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698493
DOI: 10.1002/ejhf.2492
Journal or Publication Title: Eur. J. Heart Fail.
Volume: 24
Number: 5
Page Range: S. 887 - 899
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1879-0844
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EUROPEAN ASSOCIATION; CLINICAL-OUTCOMES; HEART-FAILURE; REPLACEMENT; REGURGITATION; REPAIR; PROSTHESIS; MANAGEMENTMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69849

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