Nabergoj, Mitja ORCID: 0000-0003-2842-3198, Mauff, Katya, Beelen, Dietrich, Ganser, Arnold ORCID: 0000-0003-3510-4304, Kroeger, Nicolaus, Stoelzel, Friedrich, Finke, Juergen, Passweg, Jakob, Cornelissen, Jan, Schub, Natalie, Veelken, Joan Hendrik, Beguin, Yves, Wilson, Keith, Zuckerman, Tsila, Hunault-Berger, Mathilde, Lioure, Bruno, Porras, Rocio Parody, Turlure, Pascal, Kerre, Tessa, Koster, Linda, Hayden, Patrick J., Onida, Francesco, Scheid, Christof, Chalandon, Yves, Robin, Marie and Yakoub-Agha, Ibrahim (2022). Allogeneic hematopoietic cell transplantation in patients with therapy-related myeloid neoplasm after breast cancer: a study of the Chronic Malignancies Working Party of the EBMT. Bone Marrow Transplant., 57 (7). S. 1072 - 1079. LONDON: SPRINGERNATURE. ISSN 1476-5365

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Abstract

We performed a registry study on therapy-related myeloid neoplasm (t-MN), both therapy-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) following treatment for breast cancer who underwent a first allogeneic hematopoietic cell transplant (allo-HCT). Of 252 identified female patients (median age 57 years), 77% were transplanted for t-AML and 23% for t-MDS, with a median time from breast cancer diagnosis to the diagnosis of tMN and subsequent allo-HCT of 3.7 and 4.6 years, respectively. At transplant, 191 patients were in remission for breast cancer, while 4 were not (57 missing). T-MN was in a complete remission at the time of transplant in 67% of patients. 2-year overall survival, relapse free-survival, relapse incidence and non-relapse mortality were 50%, 45%, 33%, and 22%, respectively. Multivariable analysis revealed that if the t-MN was not in CR pre-transplant, this was associated with lower OS, RFS, and a higher relapse incidence. Seventeen cases of breast cancer recurrence were recorded after a median of 2.4 years post-transplant, and relapse of primary breast cancer accounted for 7% of deaths. This study indicates that allo-HCT for t-MN following treatment for breast cancer shows encouraging transplant outcomes. The incidence of breast cancer relapse post-transplant remains a cause for concern.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nabergoj, MitjaUNSPECIFIEDorcid.org/0000-0003-2842-3198UNSPECIFIED
Mauff, KatyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beelen, DietrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganser, ArnoldUNSPECIFIEDorcid.org/0000-0003-3510-4304UNSPECIFIED
Kroeger, NicolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoelzel, FriedrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finke, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passweg, JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelissen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schub, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veelken, Joan HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beguin, YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuckerman, TsilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunault-Berger, MathildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lioure, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porras, Rocio ParodyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turlure, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerre, TessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koster, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayden, Patrick J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onida, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chalandon, YvesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robin, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakoub-Agha, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698527
DOI: 10.1038/s41409-022-01686-7
Journal or Publication Title: Bone Marrow Transplant.
Volume: 57
Number: 7
Page Range: S. 1072 - 1079
Date: 2022
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5365
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MYELODYSPLASTIC SYNDROME; DE-NOVO; LEUKEMIA; SECONDARY; RISK; CHEMOTHERAPY; NETWORKMultiple languages
Biophysics; Oncology; Hematology; Immunology; TransplantationMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69852

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