Feltgen, Nicolas ORCID: 0000-0002-6857-3003, Ach, Thomas, Ziemssen, Focke ORCID: 0000-0002-3873-0581, Quante, Carolin Sophie, Gross, Oliver ORCID: 0000-0002-8390-8852, Abdin, Alaa Din, Aisenbrey, Sabine, Bartram, Martin C., Blum, Marcus, Brockmann, Claudia, Dithmar, Stefan, Friedrichs, Wilko, Guthoff, Rainer, Hattenbach, Lars-Olof, Herrlinger, Klaus R., Kaskel-Paul, Susanne, Khoramnia, Ramin ORCID: 0000-0002-6237-7773, Klaas, Julian E., Krohne, Tim U. ORCID: 0000-0003-2280-925X, Lommatzsch, Albrecht, Lueken, Sabine, Maier, Mathias, Nassri, Lina, Nguyen-Dang, Thien A., Radeck, Viola ORCID: 0000-0001-9312-4085, Rau, Saskia, Roider, Johann, Sandner, Dirk, Schmalenberger, Laura, Schmidtmann, Irene ORCID: 0000-0001-8743-6752, Schubert, Florian, Siegel, Helena, Spitzer, Martin S., Stahl, Andreas ORCID: 0000-0002-8013-7597, Stingl, Julia, V, Treumer, Felix, Viestenz, Arne, Wachtlin, Joachim, Wolf, Armin, Zimmermann, Julian, Schargus, Marc ORCID: 0000-0003-4445-4103 and Schuster, Alexander K. (2022). Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. J. Clin. Med., 11 (17). BASEL: MDPI. ISSN 2077-0383

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Abstract

Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were retrospectively collected during a 2-month index period (1 June-31 July 2021) according to a defined protocol. The relation to any previous vaccination was documented for the consecutive case series. Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case-control study using age- and sex-matched controls from the general population (study participants from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was conducted. Results: Four hundred and twenty-one subjects presenting during the index period (61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO, fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our case-control analysis integrating population-based data from the GHS yielded no evidence of an increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60-1.45, p = 0.75) in connection with a vaccination within a 4-week window. Conclusions: To date, there has been no evidence of any association between SARS-CoV-2 vaccination and a higher RVOD risk.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Feltgen, NicolasUNSPECIFIEDorcid.org/0000-0002-6857-3003UNSPECIFIED
Ach, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziemssen, FockeUNSPECIFIEDorcid.org/0000-0002-3873-0581UNSPECIFIED
Quante, Carolin SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gross, OliverUNSPECIFIEDorcid.org/0000-0002-8390-8852UNSPECIFIED
Abdin, Alaa DinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aisenbrey, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartram, Martin C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blum, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmann, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dithmar, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrichs, WilkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guthoff, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hattenbach, Lars-OlofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrlinger, Klaus R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaskel-Paul, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khoramnia, RaminUNSPECIFIEDorcid.org/0000-0002-6237-7773UNSPECIFIED
Klaas, Julian E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krohne, Tim U.UNSPECIFIEDorcid.org/0000-0003-2280-925XUNSPECIFIED
Lommatzsch, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueken, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nassri, LinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen-Dang, Thien A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radeck, ViolaUNSPECIFIEDorcid.org/0000-0001-9312-4085UNSPECIFIED
Rau, SaskiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roider, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sandner, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalenberger, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidtmann, IreneUNSPECIFIEDorcid.org/0000-0001-8743-6752UNSPECIFIED
Schubert, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegel, HelenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spitzer, Martin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stahl, AndreasUNSPECIFIEDorcid.org/0000-0002-8013-7597UNSPECIFIED
Stingl, Julia, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treumer, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viestenz, ArneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachtlin, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, ArminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmermann, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schargus, MarcUNSPECIFIEDorcid.org/0000-0003-4445-4103UNSPECIFIED
Schuster, Alexander K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698790
DOI: 10.3390/jcm11175101
Journal or Publication Title: J. Clin. Med.
Volume: 11
Number: 17
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RISK-FACTORS; ARTERYMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69879

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