Foeldvari, Ivan ORCID: 0000-0003-0659-5298, Klotsche, Jens, Kasapcopur, Ozgur ORCID: 0000-0002-1125-7720, Adrovic, Amra, Terreri, Maria Teresa, Sakamoto, Ana Paula, Stanevicha, Valda, Anton, Jordi ORCID: 0000-0002-8792-4219, Feldman, Brian M., Sztajnbok, Flavio, Khubchandani, Raju, Alexeeva, Ekaterina, Katsicas, Maria, Sawhney, Sujata, Smith, Vanessa, Appenzeller, Simone, Avcin, Tadej, Kostik, Mikhail, Lehman, Thomas, Marrani, Edoardo, Schonenberg-Meinema, Dieneke, Sifuentes-Giraldo, Walter-Alberto, Vasquez-Canizares, Natalia, Janarthanan, Mahesh, Moll, Monika, Nemcova, Dana, Patwardhan, Anjali, Santos, Maria Jose, Battagliotti, Cristina, Berntson, Lillemor, Bica, Blanca, Brunner, Juergen, Cimaz, Rolando, Costa-Reis, Patricia, Eleftheriou, Despina, Harel, Liora, Horneff, Gerd, Johnson, Sindhu R., Kaiser, Daniela, Kallinich, Tilmann, Lazarevic, Dragana, Minden, Kirsten, Nielsen, Susan, Nuruzzaman, Farzana, Opsahl Hetlevik, Siri, Uziel, Yosef, Helmus, Nicola and Torok, Kathryn S. . Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort. J. Scleroderma Relat. Disord.. LONDON: SAGE PUBLICATIONS LTD. ISSN 2397-1991

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Abstract

Objective: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. Methods: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months. Results: One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease duration, and disease subtypes (70% diffuse cutaneous) were similar between males and females. Active digital ulceration, very low body mass index, and tendon friction rubs were significantly more frequent in males. Physician global assessment of disease severity and digital ulcer activity was significantly higher in males. Composite pulmonary involvement was also more frequent in males, though not statistically significantly. After 12 months, they are the pattern of differences changed female patients had significantly more frequent pulmonary involvement. Conclusion: In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Foeldvari, IvanUNSPECIFIEDorcid.org/0000-0003-0659-5298UNSPECIFIED
Klotsche, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasapcopur, OzgurUNSPECIFIEDorcid.org/0000-0002-1125-7720UNSPECIFIED
Adrovic, AmraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terreri, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakamoto, Ana PaulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanevicha, ValdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton, JordiUNSPECIFIEDorcid.org/0000-0002-8792-4219UNSPECIFIED
Feldman, Brian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sztajnbok, FlavioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khubchandani, RajuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alexeeva, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katsicas, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawhney, SujataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Appenzeller, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avcin, TadejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kostik, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehman, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marrani, EdoardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonenberg-Meinema, DienekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sifuentes-Giraldo, Walter-AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasquez-Canizares, NataliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janarthanan, MaheshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moll, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemcova, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patwardhan, AnjaliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, Maria JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Battagliotti, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berntson, LillemorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bica, BlancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunner, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cimaz, RolandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa-Reis, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eleftheriou, DespinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harel, LioraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horneff, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, Sindhu R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kallinich, TilmannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazarevic, DraganaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minden, KirstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuruzzaman, FarzanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opsahl Hetlevik, SiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uziel, YosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helmus, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torok, Kathryn S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699044
DOI: 10.1177/23971983221143244
Journal or Publication Title: J. Scleroderma Relat. Disord.
Publisher: SAGE PUBLICATIONS LTD
Place of Publication: LONDON
ISSN: 2397-1991
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHILDHOOD; FEATURES; CRITERIAMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69904

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