Festari, Cristina ORCID: 0000-0003-3597-5097, Massa, Federico ORCID: 0000-0001-5667-204X, Cotta Ramusino, Matteo ORCID: 0000-0003-3090-9648, Gandolfo, Federica, Nicolosi, Valentina, Orini, Stefania, Aarsland, Dag ORCID: 0000-0001-6314-216X, Agosta, Federica ORCID: 0000-0003-3121-4979, Babiloni, Claudio, Boada, Merce, Borroni, Barbara, Cappa, Stefano, Dubois, Bruno, Frederiksen, Kristian S., Froelich, Lutz, Garibotto, Valentina ORCID: 0000-0003-2422-698X, Georges, Jean, Haliassos, Alexander, Hansson, Oskar ORCID: 0000-0001-8467-7286, Jessen, Frank, Kamondi, Anita, Kessels, Roy P. C., Morbelli, Silvia, O'Brien, John T., Otto, Markus ORCID: 0000-0003-4273-4267, Perret-Liaudet, Armand, Pizzini, Francesca B., Ritchie, Craig W., Scheltens, Philip, Vandenbulcke, Mathieu ORCID: 0000-0001-9765-1499, Vanninen, Ritva, Verhey, Frans, Vernooij, Meike W., Yousry, Tarek, Van der Flier, Wiesje M., Nobili, Flavio and Frisoni, Giovanni B. ORCID: 0000-0002-6419-1753 . European consensus for the diagnosis of MCI and mild dementia: Preparatory phase. Alzheimers. Dement.. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers' use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Festari, CristinaUNSPECIFIEDorcid.org/0000-0003-3597-5097UNSPECIFIED
Massa, FedericoUNSPECIFIEDorcid.org/0000-0001-5667-204XUNSPECIFIED
Cotta Ramusino, MatteoUNSPECIFIEDorcid.org/0000-0003-3090-9648UNSPECIFIED
Gandolfo, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nicolosi, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orini, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aarsland, DagUNSPECIFIEDorcid.org/0000-0001-6314-216XUNSPECIFIED
Agosta, FedericaUNSPECIFIEDorcid.org/0000-0003-3121-4979UNSPECIFIED
Babiloni, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boada, MerceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borroni, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cappa, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frederiksen, Kristian S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froelich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garibotto, ValentinaUNSPECIFIEDorcid.org/0000-0003-2422-698XUNSPECIFIED
Georges, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haliassos, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansson, OskarUNSPECIFIEDorcid.org/0000-0001-8467-7286UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamondi, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessels, Roy P. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morbelli, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Brien, John T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Otto, MarkusUNSPECIFIEDorcid.org/0000-0003-4273-4267UNSPECIFIED
Perret-Liaudet, ArmandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pizzini, Francesca B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritchie, Craig W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandenbulcke, MathieuUNSPECIFIEDorcid.org/0000-0001-9765-1499UNSPECIFIED
Vanninen, RitvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhey, FransUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vernooij, Meike W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yousry, TarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nobili, FlavioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frisoni, Giovanni B.UNSPECIFIEDorcid.org/0000-0002-6419-1753UNSPECIFIED
URN: urn:nbn:de:hbz:38-699260
DOI: 10.1002/alz.12798
Journal or Publication Title: Alzheimers. Dement.
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS-DISEASE; DELPHI TECHNIQUE; GUIDELINES; CRITERIA; TOOLMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69926

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