Sousa-Pinto, Bernardo ORCID: 0000-0002-1277-3401, Schunemann, Holger J., Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia ORCID: 0000-0001-5077-8329, Brozek, Jan, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo ORCID: 0000-0002-0658-2449, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun ORCID: 0000-0001-5953-4881, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor ORCID: 0000-0002-4708-0859, Khaitov, Musa ORCID: 0000-0003-4961-9640, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Moesges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhan, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna ORCID: 0000-0003-0890-6686, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A. and Bousquet, Jean (2022). Comparison of rhinitis treatments using MASK-air (R) data and considering the minimal important difference. Allergy, 77 (10). S. 3002 - 3015. HOBOKEN: WILEY. ISSN 1398-9995

Full text not available from this repository.

Abstract

Background Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., real-world data). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. Methods We assessed the MASK-air (R) app data (May 2015-December 2020) by users self-reporting AR (16-90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. Results We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71-0.80). Conclusion Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sousa-Pinto, BernardoUNSPECIFIEDorcid.org/0000-0002-1277-3401UNSPECIFIED
Schunemann, Holger J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sa-Sousa, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieira, Rafael JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amaral, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anto, Josep M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czarlewski, WienczyslawaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, JoaquimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedbrook, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brussino, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kvedariene, VioletaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larenas-Linnemann, DesireeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, YoshitakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ventura, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agache, IoanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansotegui, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, Karl C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosnic-Anticevich, SinthiaUNSPECIFIEDorcid.org/0000-0001-5077-8329UNSPECIFIED
Brozek, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canonica, G. WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardona, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carreiro-Martins, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casale, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cecchi, LorenzoUNSPECIFIEDorcid.org/0000-0002-0658-2449UNSPECIFIED
Chivato, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, Derek K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, CemalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Elisio M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz, Alvaro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Giacco, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devillier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eklund, PatrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, Wytske J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gemicioglu, BilunUNSPECIFIEDorcid.org/0000-0001-5953-4881UNSPECIFIED
Haahtela, TariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivancevich, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ispayeva, ZhanatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jutel, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuna, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaidashev, IgorUNSPECIFIEDorcid.org/0000-0002-4708-0859UNSPECIFIED
Khaitov, MusaUNSPECIFIEDorcid.org/0000-0003-4961-9640UNSPECIFIED
Kraxner, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laune, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipworth, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Louis, RenaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makris, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monti, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morais-Almeida, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niedoszytko, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, Nikolaos G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patella, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pham-Thi, NhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regateiro, Frederico S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reitsma, SietzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rouadi, Philip W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samolinski, BoleslawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheikh, AzizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sova, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todo-Bom, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taborda-Barata, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toppila-Salmi, SannaUNSPECIFIEDorcid.org/0000-0003-0890-6686UNSPECIFIED
Sastre, JoaquinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsiligianni, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valiulis, ArunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandenplas, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallace, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waserman, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yorgancioglu, ArzuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zidarn, MihaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuberbier, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fonseca, Joao A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699474
DOI: 10.1111/all.15371
Journal or Publication Title: Allergy
Volume: 77
Number: 10
Page Range: S. 3002 - 3015
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AIR-POLLUTION; SCOREMultiple languages
Allergy; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69947

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item