Universität zu Köln

Schulte, Elena ORCID: 0000-0003-3052-0907, Müller, Dolores Thea, Schröder, Wolfgang, Fuchs, Hans F., Babic, Benjamin, Knepper, Laura, Fuchs, Claudia, Bruns, Christiane J. and Leers, Jessica M. (2020). Software improvement for evaluation of laryngopharyngeal ph testing (Restech)- a comparison between DataView 3 and 4. PhD thesis, Universität zu Köln.

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Abstract

BACKGROUND When gastroesophageal reflux contents reach above the upper esophageal sphincter, patients may, in addition to typical reflux symptoms, present with atypical, extraesophageal symptoms related to laryngopharyngeal reflux (LPR). Surgical treatment of LPR has shown to lead to 70% symptom improvement, however no gold standard for the diagnosis of LPR exists. In 2007, the Restech Dx-pH was released as a valid method to measure acid exposure above the upper esophageal sphincter. Recently, a new software update was introduced for analysis of measured pH data and calculation of composite scores. The effect of the changes applied to the new software version have not yet been analyzed. AIM To compare results generated by DataView 3 to the most recently released DataView 4. METHODS All patients with gastroesophageal reflux disease symptoms were seen in a specialized surgical outpatient clinic for gastrointestinal function testing. Retrospective chart review was performed of all patients presenting with suspected gastroesophageal reflux disease and extraesophageal reflux symptoms, who underwent laryngopharyngeal pH monitoring using the Restech Dx-pH system (Respiratory Technology Corp., Houston, TX, United States) and simultaneous esophageal pH monitoring. DataView 3 and DataView 4 were used to evaluate Restech studies obtained. Diary entries such as mealtimes, supine and upright periods, and symptoms were entered manually to ensure accuracy and precise conversion of data between both software versions. Pairedttest was performed for statistical analysis of results. RESULTS A total of 174 patients (63.8% female) met inclusion criteria, all suffering from extraesophageal reflux symptoms as well as typical gastroesophageal reflux disease symptoms. Mean RYAN score upright was 48.77 in DataView 3 compared to 22.17 in DataView 4, showing a significant difference (P-a= 0.0001). Similar results were shown for supine period (mean RYAN Score DataView 3 5.29vs1.42 in DataView 4,(c) P= 0.0001). For upright periods 80 patients showed a decrease of value of the RYAN score with a mean of -58.9 (mean 51.1% decrease). For supine position 25 patients showed a decrease of value of the RYAN score with a mean of -15.13 [range (-153.44)-(-0.01)], which equals a mean decrease of value of 44.5%. Ten patients showed no oropharyngeal acid exposure in DataView 3, but mild/moderate (n= 7) or severe (n= 3) acid exposure in DataView 4. Correlation with positive esophageal pH measurement was improved in all 10 patients. CONCLUSION Results of both software versions cannot be compared to each other. However, our data suggests that DataView 4 may be an improvement of the Restech pH measurement in the evaluation of LPR.

Item Type:	Thesis (PhD thesis)
Translated title:	Title Language Software improvement for evaluation of laryngopharyngeal ph testing (Restech)- a comparison between DataView 3 and 4 UNSPECIFIED
Creators:	Creators Email ORCID ORCID Put Code Schulte, Elena elena_schulte@outlook.de orcid.org/0000-0003-3052-0907 UNSPECIFIED Müller, Dolores Thea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schröder, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Hans F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Babic, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Knepper, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leers, Jessica M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-710847
DOI:	10.4240/wjgs.v12.i5.236
Date:	27 May 2020
Publisher:	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Place of Publication:	World Journal of Gastrointestinal Surgery
ISBN:	1948-9366
Language:	German
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language GASTROESOPHAGEAL-REFLUX DISEASE; NORMAL VALUES; CLASSIFICATION; DIAGNOSIS UNSPECIFIED Gastroenterology & Hepatology; Surgery UNSPECIFIED
Date of oral exam:	10 May 2023
Referee:	Name Academic Title Fuchs, Hans- F Prof. Dr. med Töx, Ulrich Prof.Dr.med.
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/71084