Universität zu Köln

Miestereck, Jan David Michael (2024). Neue spiroergometrische Messfaktoren und ihre Bedeutung für das perioperative Risiko bei großen abdominellen Operationen – eine retrospektive Kohortenstudie. PhD thesis, Universität zu Köln.

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Abstract

Diese Arbeit zeigt, dass das PETCO2 unter Belastung und die DLCO eine prädiktive Aussagekraft für das Gesamtüberleben nach größeren Darmkrebsoperationen haben. Diese bei-den Parameter können einen Mehrwert für die bestehende präoperative Risikoeinschätzung gegenüber einer klassischen Spiroergometrie leisten, da sie unabhängig von einem aufwendi-gen Spiroergometrie-Labor und deutlich kosteneffizienter durchführbar sind. Die Entwicklung solcher Marker ist erforderlich, um eine klinische Verfügbarkeit durch Point-of-Care-Methoden zur präoperativen Risikoabschätzung zu erzielen, welche somit zur Verbesserung des posto-perativen Ergebnisses beitragen und das aktuell hohe Sterberisiko innerhalb von 30 Tagen nach großen abdominellen Operation reduzieren. Zusammenfassend lässt sich sagen, dass die Veränderungen von PETCO2 in der frühen Phase der Belastung und DLCO in Ruhe Unterschiede für das Gesamtüberleben zeigen und in der konventionellen CPET-Analyse mög-licherweise übersehen werden. Diese leicht verfügbaren zwei Parameter sind valide Marker zur präoperativen Risikoabschätzung und leisten somit einen wichtigen Beitrag für die peri-operative Versorgung von Patienten, welche sich einer großen abdominellen Operation unter-ziehen müssen.

Item Type:	Thesis (PhD thesis)
Creators:	Creators Email ORCID ORCID Put Code Miestereck, Jan David Michael miestereck@web.de UNSPECIFIED UNSPECIFIED
Corporate Creators:	Aus der Klinik für Anästhesiologie und Operative Intensivmedizin der Universität zu Köln Direktor: Universitätsprofessor Dr. B. W. Böttiger
URN:	urn:nbn:de:hbz:38-720057
Date:	2024
Language:	German
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Anästhesiologie und Operative Intensivmedizin > Klinik für Anästhesiologie und Operative Intensivmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Spiroergometrie German CPET; cardiopulmonary preoperative exercise testing English DLCO; Diffusion capacity of the lung English
Date of oral exam:	27 November 2023
Referee:	Name Academic Title Robert Schier, Robert Prof. Dr. med. Stippel, Dirk Univ.-Prof. Dr. med.
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Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/72005