Universität zu Köln

Koob, Janusz Lazlo ORCID: 0000-0002-0898-031X (2024). Mechanisms and Perspectives of Post-Stroke Depression: Neuroanatomical Substrates, Incentive Motivation, and Emotional Processing. PhD thesis, Universität zu Köln.

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Abstract

Post-stroke depression (PSD) is a prevalent affective condition after a stroke, which can impair functional and motor rehabilitation. The present dissertation and the included studies aim to further our understanding of how different mechanisms after stroke affect the emergence and maintenance of depressive symptoms on different pathological levels. For this, three separate studies were executed using several methodological applications, including different lesion-symptom mapping approaches, experimental task designs with different behavioral parameters, interviews, and test batteries. Study 1 investigated the link between anatomical brain lesions and specific PSD symptoms in a large stroke sample using a support-vector regression lesion-symptom mapping approach. Rather than treating depression as a single global score, lesion locations contributing to distinct PSD symptom domains were identified and analyzed. Study 2 examined the relationship between motor impairment and incentive motivation early after stroke and PSD symptoms, specifically motivational deficits. We were specifically interested in whether differences in motivation for physically demanding tasks could predict the development of PSD in patients with residual motor impairments. As disrupted emotion processing abilities can deteriorate social relationships and promote and maintain depressive symptoms study 3 examined emotion processing deficits after stroke and their relationship with PSD. Taken together, our findings contribute to a further understanding of the pathophysiology of PSD and how psychological and neurological influences interact in the development, maintenance, and treatment of depression after stroke. This should help to advance personalized therapeutic approaches and alleviate the burden of PSD characteristics for patients and caregivers.

Item Type:	Thesis (PhD thesis)
Creators:	Creators Email ORCID ORCID Put Code Koob, Janusz Lazlo janusz.koob@uk-koeln.de orcid.org/0000-0002-0898-031X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-726313
Date:	2024
Language:	English
Faculty:	Faculty of Human Sciences
Divisions:	Faculty of Human Sciences > Department Psychologie
Subjects:	Psychology Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language stroke English post-stroke depression English lesion-symptom mapping English incentive motivation English motor impairment English emotion processing English
Date of oral exam:	12 March 2024
Referee:	Name Academic Title Peters, Jan Prof. Dr Rehme, Anne Priv.-Doz. Dr.
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/72631