Universität zu Köln

Wang, Xiaosha (2024). Comparative Proteomic Analysis of Regenerative and Degenerated Mouse Retinas. PhD thesis, Universität zu Köln.

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Abstract

In this study, we utilized retinal ganglion cell (RGC) degeneration and regeneration models along with DIA-MS to investigate proteomic alterations during these processes. Collaborative up-regulated signaling pathways involving thyroid hormone, Notch, and Wnt were observed during RGC regeneration, with key players such as SIR1, CBP, EP300, and CaMKIIα identified. Furthermore, critical molecular players, including ITPR1, M3K5, CIO72 and CASP9, were identified as up-regulated in degenerated retinas. This research provides insight into the molecular mechanisms underlying glaucomatous RGC degeneration and regeneration. Future studies should further investigate the identified pathways, proteins, and their interactions developing therapeutic strategies to protect and regenerate RGCs in glaucoma and other neurodegenerative conditions. Understanding these processes is crucial for advancing the knowledge of vision loss and potential treatments to improve treatment strategies in glaucoma.

Item Type:	Thesis (PhD thesis)
Creators:	Creators Email ORCID ORCID Put Code Wang, Xiaosha xiaoshawang0@gmail.com UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-788003
Date:	2024
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Augenheilkunde
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language SIRT1 UNSPECIFIED CBP UNSPECIFIED EP300 UNSPECIFIED
Date of oral exam:	10 July 2025
Referee:	Name Academic Title Liu, Hanhan Dr.
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/78800