Universität zu Köln

Ahmad, Waleed K.M. ORCID: 0009-0000-2167-8951, Bedau, Tillmann ORCID: 0000-0001-7510-2261, Wang, Yuan, Michels, Sebastian ORCID: 0000-0003-3164-870X, Rasokat, Anna ORCID: 0009-0008-7850-6374, Wolf, Jürgen ORCID: 0000-0001-8833-8812, Heldwein, Matthias ORCID: 0000-0002-2084-795X, Schallenberg, Simon, Quaas, Alexander ORCID: 0000-0002-3537-6011, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Tolkach, Yuri ORCID: 0000-0001-5239-2841 (2025). Development and clinical validation of a prognostic algorithm for stroma-tumor ratio quantification in non-small cell lung cancer. Lung Cancer, 205. pp. 1-10. Elsevier. ISSN 0169-5002

Altin, Selver, Simões, Tânia, Behrendt, Christina, Anton, Vincent, Domke, Dennis, Völtzke, Kai Mayor, Kumar, Rajesh, Nolte, Hendrik, Hermanns, Thomas, Brocke-Ahmadinejad, Nahal, Bendrin, Katja, Zimmermann, Marcel, Büttner, Reinhard, Ventura, Natascia, Krüger, Marcus, Dohmen, R. Jürgen, Hofmann, Kay, Hoppe, Thorsten, Reichert, Andreas S. and Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119 (2025). Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity. Molecular Cell, 85 (19). 3677-3693.e7. Elsevier. ISSN 1097-2765

Barroso, Vincenzo Mitchell ORCID: 0009-0006-7961-089X, Weng, Zhilong ORCID: 0009-0002-0321-9406, Glamann, Lennert, Bauer, Marcus, Wickenhauser, Claudia, Zander, Thomas ORCID: 0000-0002-4266-6818, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Quaas, Alexander ORCID: 0000-0002-3537-6011 and Tolkach, Yuri ORCID: 0000-0001-5239-2841 (2025). Artificial Intelligence–Based Single-Cell Analysis as a Next-Generation Histologic Grading Approach in Colorectal Cancer: Prognostic Role and Tumor Biology Assessment. Modern Pathology, 38 (7). pp. 1-11. Elsevier. ISSN 08933952

Fischer, Anne Kristin ORCID: 0000-0003-0665-9693, Heydt, Carina ORCID: 0000-0003-3184-9579, Siemanowski-Hrach, Janna ORCID: 0009-0000-8453-5229, Alibegovic, Vedat, Hauptmann, Kathrin, Vokuhl, Christian, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Fischer, Hans-Peter ORCID: 0000-0003-2584-4958 (2025). GNAQ-/GNA14-mutated hepatic vascular malformation with capillary proliferation in adults and children. Human Pathology, 165. pp. 1-10. Elsevier. ISSN 0046-8177

Fischer, Anne Kristin ORCID: 0000-0003-0665-9693, Kroesen, Anton and Büttner, Reinhard ORCID: 0000-0001-8806-4786 (2025). Sekundäre maligne Neoplasien auf dem Boden eines Lynch-Syndroms mit koinzidenter Colitis ulcerosa. Die Chirurgie, 96 (5). pp. 415-420. Springer Nature. ISSN 2731-6971

Grothey, Bastian ORCID: 0000-0002-0883-6481, Odenkirchen, Jan, Brkic, Adnan, Schömig-Markiefka, Birgid ORCID: 0000-0003-1893-8796, Quaas, Alexander ORCID: 0000-0002-3537-6011, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Tolkach, Yuri ORCID: 0000-0001-5239-2841 (2025). Comprehensive testing of large language models for extraction of structured data in pathology. Communications Medicine, 5 (1). ISSN 2730-664X

Kludt, Carina, Wang, Yuan, Ahmad, Waleed, Bychkov, Andrey, Fukuoka, Junya, Gaisa, Nadine, Kühnel, Mark, Jonigk, Danny, Pryalukhin, Alexey, Mairinger, Fabian, Klein, Franziska, Schultheis, Anne Maria, Seper, Alexander, Hulla, Wolfgang, Brägelmann, Johannes, Michels, Sebastian, Klein, Sebastian, Quaas, Alexander, Büttner, Reinhard and Tolkach, Yuri (2024). Next-generation lung cancer pathology: Development and validation of diagnostic and prognostic algorithms. Cell Reports Medicine, 5 (9). pp. 1-20. Elsevier. ISSN 2666-3791

Naji, Hussein ORCID: 0009-0008-0665-233X, Hahn, Paul ORCID: 0009-0009-7708-8040, Pisula, Juan I. ORCID: 0000-0002-6131-8528, Ugliano, Stefano ORCID: 0009-0002-5013-3971, Simon, Adrian ORCID: 0000-0002-2709-863X, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Bozek, Katarzyna ORCID: 0000-0002-0917-6876 (2025). Deep learning-based interpretable prediction of recurrence of diffuse large B-cell lymphoma. BJC Reports, 3 (1). pp. 1-6. Springer Nature. ISSN 2731-9377

Prinz, Lars Fabian ORCID: 0000-0002-3580-7627, Riet, Tobias ORCID: 0000-0002-8211-7071, Neureuther, Daniel Felix, Lennartz, Simon ORCID: 0000-0001-7202-398X, Chrobok, Danuta, Hübbe, Hanna, Uhl, Gregor ORCID: 0000-0003-3792-1076, Riet, Nicole, Hofmann, Petra, Hösel, Marianna, Simon, Adrian Georg ORCID: 0000-0002-2709-863X, Tetenborg, Luis, Segbers, Paul, Shimono, Joji, Gödel, Philipp ORCID: 0000-0001-7887-8313, Balke-Want, Hyatt ORCID: 0000-0002-5963-7626, Flümann, Ruth ORCID: 0000-0002-7147-7557, Knittel, Gero, Reinhardt, Hans Christian, Scheid, Christoph ORCID: 0009-0007-6539-226X, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Chapuy, Björn, Ullrich, Roland Tillmann, Hallek, Michael ORCID: 0000-0002-7425-4455 and Chmielewski, Markus Martin ORCID: 0000-0001-9348-5219 (2024). An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL. Cell Reports Medicine, 5 (2). pp. 1-26. Elsevier. ISSN 2666-3791

Rose, France ORCID: 0000-0001-5828-3259, Ibruli, Olta, Lichius, Luca, Kiljan, Martha ORCID: 0000-0002-5581-1359, Gozum, Gokcen ORCID: 0000-0002-8650-0078, Caiaffa, Manoela Iannicelli ORCID: 0009-0007-0704-0397, Cai, Jiali ORCID: 0009-0009-5976-0235, Niu, Li-na ORCID: 0000-0002-6653-0819, Herter, Jan M., Grüll, Holger ORCID: 0000-0002-0993-9300, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Beleggia, Filippo ORCID: 0000-0003-0234-7094, Bosco, Graziella ORCID: 0000-0001-6601-4518, George, Julie ORCID: 0000-0002-4272-3683, Herter-Sprie, Grit S., Reinhardt, Hans Christian and Bozek, Katarzyna ORCID: 0000-0002-0917-6876 (2025). Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. BMC Research Notes, 18 (1). pp. 1-4. Springer Nature. ISSN 1756-0500

Sakthivelu, Vignesh ORCID: 0009-0000-1652-0850, Schmitt, Anna ORCID: 0009-0002-7655-1805, Odenthal, Franka ORCID: 0000-0003-4138-121X, Ndoci, Kristiano ORCID: 0000-0002-9896-8196, Touet, Marian ORCID: 0009-0004-7875-1880, Shaib, Ali H., Chihab, Abdulla ORCID: 0009-0002-1237-0087, Wani, Gulzar A. ORCID: 0000-0003-2380-5816, Nieper, Pascal ORCID: 0000-0003-0607-3561, Hartmann, Griffin G. ORCID: 0000-0001-9213-8995, Pintelon, Isabel, Kisis, Ilmars ORCID: 0000-0001-6207-3991, Boecker, Maike ORCID: 0009-0008-0595-8599, Eckert, Naja M. ORCID: 0009-0007-2888-0280, Iannicelli Caiaffa, Manoela ORCID: 0009-0007-0704-0397, Ibruli, Olta, Weber, Julia, Maresch, Roman ORCID: 0000-0003-3393-8882, Bebber, Christina M. ORCID: 0000-0002-7841-7493, Chitsaz, Ali, Lütz, Anna ORCID: 0009-0000-2891-7038, Kim Alves Carpinteiro, Mira ORCID: 0009-0009-9941-3027, Morris, Kaylee M. ORCID: 0009-0009-4455-2951, Franchino, Camilla A. ORCID: 0009-0002-4502-6514, Benz, Jonas ORCID: 0009-0007-6053-2796, Pérez-Revuelta, Laura ORCID: 0000-0002-9010-8220, Soriano-Campos, Jorge A. ORCID: 0000-0002-7237-8630, Huetzen, Maxim A. ORCID: 0009-0008-2217-813X, Goergens, Jonas, Jevtic, Milica, Jahn-Kelleter, Hannah M., Zempel, Hans ORCID: 0000-0002-7510-3077, Placzek, Aleksandra, Hennrich, Alexandru A. ORCID: 0000-0002-3233-6145, Conzelmann, Karl-Klaus ORCID: 0000-0002-8614-3656, Tumbrink, Hannah L. ORCID: 0009-0007-8256-7498, Hunold, Pascal ORCID: 0000-0002-7087-5908, Isensee, Joerg ORCID: 0000-0002-3390-0051, Werr, Lisa ORCID: 0000-0002-3697-4136, Gaedke, Felix ORCID: 0000-0002-7744-4940, Schauss, Astrid ORCID: 0000-0002-6658-2192, Minère, Marielle ORCID: 0000-0001-7889-9771, Müller, Marie, Fenselau, Henning ORCID: 0000-0001-7136-9751, Liu, Yin ORCID: 0000-0002-2377-2703, Heimsoeth, Alena ORCID: 0009-0008-9076-8537, Gülcüler Balta, Gülce S. ORCID: 0000-0002-3626-007X, Walczak, Henning ORCID: 0000-0002-6312-4591, Frezza, Christian ORCID: 0000-0002-3293-7397, Jachimowicz, Ron D. ORCID: 0000-0001-9522-7061, George, Julie ORCID: 0000-0002-4272-3683, Schmiel, Marcel, Brägelmann, Johannes ORCID: 0000-0002-1306-2169, Hucho, Tim ORCID: 0000-0002-4147-9308, von Karstedt, Silvia ORCID: 0000-0002-7816-5919, Peifer, Martin ORCID: 0000-0002-5243-5503, Annibaldi, Alessandro, Hänsel-Hertsch, Robert ORCID: 0000-0002-2835-4471, Persigehl, Thorsten ORCID: 0000-0001-5928-4405, Grüll, Holger ORCID: 0000-0002-0993-9300, Sos, Martin L. ORCID: 0000-0002-2868-100X, Reifenberger, Guido, Fischer, Matthias ORCID: 0000-0003-1363-1242, Adriaensen, Dirk, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Sage, Julien ORCID: 0000-0002-8928-9968, Brouns, Inge, Rad, Roland ORCID: 0000-0002-6849-9659, Thomas, Roman K. ORCID: 0000-0001-9132-4876, Anstötz, Max ORCID: 0000-0003-3071-5835, Rizzoli, Silvio O. ORCID: 0000-0002-1667-7839, Bergami, Matteo ORCID: 0000-0001-5525-5025, Motori, Elisa ORCID: 0000-0001-5997-6866, Reinhardt, Hans Christian ORCID: 0000-0001-5706-9349 and Beleggia, Filippo ORCID: 0000-0003-0234-7094 (2025). Functional synapses between neurons and small cell lung cancer. Nature, 646 (8087). pp. 1243-1253. Nature Publ. Group. ISSN 0028-0836

Scheel, Andreas H., Lamberty, Hannah, Tolkach, Yuri ORCID: 0000-0001-5239-2841, Gebauer, Florian ORCID: 0000-0001-5312-4814, Schömig-Markiefka, Birgid ORCID: 0000-0003-1893-8796, Zander, Thomas ORCID: 0000-0002-4266-6818, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Rueschoff, Josef, Bruns, Christiane J. ORCID: 0000-0001-6590-8181, Schröder, Wolfgang ORCID: 0000-0002-8700-069X and Quaas, Alexander ORCID: 0000-0002-3537-6011 (2023). Tumour area infiltration and cell count in endoscopic biopsies of therapy-naive upper GI tract carcinomas by QuPath analysis: implications for predictive biomarker testing. Scientific Reports, 13 (1). p. 17580. Springer Nature. ISSN 2045-2322

Simon, Adrian Georg ORCID: 0000-0002-2709-863X, Lyu, Su Ir ORCID: 0009-0002-4125-6048, Laible, Mark, Wöll, Stefan, Türeci, Özlem, Şahin, Uğur, Alakus, Hakan ORCID: 0000-0002-3889-3276, Fahrig, Luca, Zander, Thomas ORCID: 0000-0002-4266-6818, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Bruns, Christiane Josephine ORCID: 0000-0001-6590-8181, Schröder, Wolfgang ORCID: 0000-0002-8700-069X, Gebauer, Florian ORCID: 0000-0001-5312-4814 and Quaas, Alexander ORCID: 0000-0002-3537-6011 (2023). The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis. Journal of Translational Medicine, 21 (1). p. 552. Springer Nature. ISSN 1479-5876

Stahl, David, Gödel, Philipp ORCID: 0000-0001-7887-8313, Balke-Want, Hyatt ORCID: 0000-0002-5963-7626, Gholamipoorfard, Rahil ORCID: 0000-0001-8207-7295, Segbers, Paul, Tetenborg, Luis, Koker, Mirjam, Dörr, Janina, Gregor, Lisa, Bachurski, Daniel ORCID: 0000-0001-9168-9680, Rose, France ORCID: 0000-0001-5828-3259, Simon, Adrian G. ORCID: 0000-0002-2709-863X, Good, Zinaida, Jakob, Josefine, Häupl, Björn, Nill, Marieke, Flümann, Ruth ORCID: 0000-0002-7147-7557, Riët, Tobias ORCID: 0000-0002-8211-7071, Lange, Dinah ORCID: 0000-0002-2933-2143, Blakemore, Stuart J. ORCID: 0000-0003-2892-1162, Baurmann, Herrad, Voltin, Conrad-Amadeus, Potter, Nicole, Schlözer, Lilli, Freihammer, Max, Wagener-Ryczek, Svenja ORCID: 0000-0002-2870-5606, Iuga, Andra-Iza, Heger, Jan-Michel ORCID: 0000-0001-9463-8504, Ludwig, Hanna, Schleifenbaum, Julia K. ORCID: 0000-0001-7204-3235, Propp, Jessica ORCID: 0009-0007-1656-5275, Bröckelmann, Paul J. ORCID: 0000-0001-9662-9900, Jachimowicz, Ron D. ORCID: 0000-0001-9522-7061, Knittel, Gero Thomas ORCID: 0000-0001-8395-3701, Borchmann, Sven ORCID: 0000-0001-6662-6864, Merkelbach-Bruse, Sabine ORCID: 0000-0002-0312-5760, Pallasch, Christian P. ORCID: 0000-0001-5675-6905, Peifer, Martin ORCID: 0000-0002-5243-5503, Rybniker, Jan ORCID: 0000-0001-8351-2690, Quaas, Alexander ORCID: 0000-0002-3537-6011, Nitz, Mark, Brägelmann, Johannes, Müller, Werner, Persigehl, Thorsten ORCID: 0000-0001-5928-4405, Bozek, Katarzyna ORCID: 0000-0002-0917-6876, Theobald, Sebastian J. ORCID: 0000-0001-7042-8326, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Oellerich, Thomas ORCID: 0000-0001-6570-6125, Hallek, Michael ORCID: 0000-0002-7425-4455, Kobold, Sebastian, Chmielewski, Markus ORCID: 0000-0001-9348-5219, Reinhardt, Hans Christian ORCID: 0000-0001-5706-9349, Mackall, Crystal, Abedpour, Nima ORCID: 0000-0002-2933-8035, Borchmann, Peter ORCID: 0000-0003-3782-2158 and Ullrich, Roland T. (2025). CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma. Cancer Cell, 43 (8). 1476-1494.e10. Elsevier. ISSN 1535-6108

Tolkach, Yuri ORCID: 0000-0001-5239-2841, Ovtcharov, Vlado, Pryalukhin, Alexey, Eich, Marie-Lisa ORCID: 0000-0002-8601-4598, Gaisa, Nadine Therese, Braun, Martin, Radzhabov, Abdukhamid ORCID: 0000-0003-1948-5792, Quaas, Alexander ORCID: 0000-0002-3537-6011, Hammerer, Peter, Dellmann, Ansgar, Hulla, Wolfgang, Haffner, Michael C., Reis, Henning, Fahoum, Ibrahim, Samarska, Iryna ORCID: 0000-0003-4092-0672, Borbat, Artem ORCID: 0000-0002-9699-8375, Pham, Hoa, Heidenreich, Axel ORCID: 0000-0002-2511-3664, Klein, Sebastian ORCID: 0000-0002-2188-9377, Netto, George, Caie, Peter and Büttner, Reinhard ORCID: 0000-0001-8806-4786 (2023). An international multi-institutional validation study of the algorithm for prostate cancer detection and Gleason grading. npj Precision Oncology, 7 (1). p. 77. Springer Nature. ISSN 2397-768X

Wang, Yuan, Lami, Kris, Ahmad, Waleed, Schallenberg, Simon, Bychkov, Andrey, Ye, Yuanzi, Jonigk, Danny, Zhu, Xiaoya, Campelos, Sofia, Schultheis, Anne, Heldwein, Matthias ORCID: 0000-0002-2084-795X, Quaas, Alexander ORCID: 0000-0002-3537-6011, Ryska, Ales, Moreira, Andre L., Fukuoka, Junya, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Tolkach, Yuri ORCID: 0000-0001-5239-2841 (2025). AI Algorithm for Lung Adenocarcinoma Pattern Quantification (PATQUANT): International Validation and Advanced Risk Stratification Superior to Conventional Grading. MedComm, 6 (9). pp. 1-14. Wiley. ISSN 2688-2663

vom Stein, Alexander F. ORCID: 0000-0002-6910-7792, Rebollido-Rios, Rocio ORCID: 0000-0002-8910-867X, Lukas, Anna, Koch, Maximilian, von Lom, Anton ORCID: 0009-0005-6907-9962, Reinartz, Sebastian, Bachurski, Daniel ORCID: 0000-0001-9168-9680, Rose, France ORCID: 0000-0001-5828-3259, Bozek, Katarzyna ORCID: 0000-0002-0917-6876, Abdallah, Ali T., Kohlhas, Viktoria ORCID: 0000-0001-8133-1001, Saggau, Julia ORCID: 0000-0002-9908-5467, Zölzer, Rebekka, Zhao, Yue, Bruns, Christiane J. ORCID: 0000-0001-6590-8181, Bröckelmann, Paul J. ORCID: 0000-0001-9662-9900, Lohneis, Philipp, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Häupl, Björn, Oellerich, Thomas ORCID: 0000-0001-6570-6125, Nguyen, Phuong-Hien ORCID: 0000-0002-3249-7264 and Hallek, Michael ORCID: 0000-0002-7425-4455 (2023). LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. Nature Communications, 14 (1). p. 1330. Springer Nature. ISSN 2041-1723