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Dapper, Hendrik ORCID: 0009-0005-8041-3634, Fleischmann, Maximilian, Tselis, Nikolaos, Diefenhardt, Markus ORCID: 0000-0002-9042-9729, Hofheinz, Ralf-Dieter, Weiß, Christian ORCID: 0009-0009-0497-2513, Grabenbauer, Gerhard G., Merten, Ricarda, Grosu, Anca-Ligia, Kirste, Simon, Rieken, Stefan, Claßen, Johannes, Langer, Christian, Kuhnt, Thomas, Schmidberger, Heinz, Ghadimi, Michael, Giordano, Frank, Nestle, Ursula, Koerber, Stefan A., Bock, Felix ORCID: 0009-0001-5795-9509, Geiger, Matthias, Polat, Bülent, Bruns, Christiane J., Dieplinger, Georg, Popp, Felix, Zander, Thomas, Brunner, Thomas, Tribius, Silke, Arnold, Dirk, Wurschi, Georg ORCID: 0000-0002-8751-9862, Piso, Pompiliu ORCID: 0000-0001-7146-4505, Friede, Tim ORCID: 0000-0001-5347-7441, Hörner-Rieber, Juliane, Gkika, Eleni, Rödel, Claus ORCID: 0009-0006-1777-2359 and Fokas, Emmanouil ORCID: 0000-0003-1601-6165 (2025). ACO/ARO/AIO-22 – External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group. Clinical and Translational Radiation Oncology, 53. p. 100958. Elsevier. ISSN 2405-6308