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Journal Article
Aden, Konrad ORCID: 0000-0003-3482-7316, Tran, Florian, Ito, Go, Sheibani-Tezerji, Raheleh, Lipinski, Simone, Kuiper, Jan W., Tschurtschenthaler, Markus
ORCID: 0000-0002-0060-4790, Saveljeva, Svetlana, Bhattacharyya, Joya
ORCID: 0000-0003-1745-4167, Haesler, Robert, Bartsch, Kareen, Luzius, Anne, Jentzsch, Marlene, Falk-Paulsen, Maren, Stengel, Stephanie T., Welz, Lina, Schwarzer, Robin, Rabe, Bjoern, Barchet, Winfried
ORCID: 0000-0002-6745-6606, Krautwald, Stefan
ORCID: 0000-0001-7768-2132, Hartmann, Gunther
ORCID: 0000-0003-1021-2018, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Blumberg, Richard S., Schreiber, Stefan, Kaser, Arthur and Rosenstiel, Philip
ORCID: 0000-0002-9692-8828
(2018).
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
J. Exp. Med., 215 (11).
S. 2868 - 2887.
NEW YORK:
ROCKEFELLER UNIV PRESS.
ISSN 1540-9538
Androulidaki, Ariadne, Wachsmuth, Laurens, Polykratis, Apostolos ORCID: 0000-0001-6720-3302 and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2018).
Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes.
PLoS One, 13 (3).
SAN FRANCISCO:
PUBLIC LIBRARY SCIENCE.
ISSN 1932-6203
Armaka, Marietta, Ospelt, Caroline ORCID: 0000-0002-9151-4650, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Kollias, George
(2018).
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.
Nat. Commun., 9.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
D'Cruz, Akshay A., Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Chen, Alyce A., Gavillet, Mathilde, Lawlor, Kate E., Vince, James E., Kelliher, Michelle, Hakem, Razq, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Williams, David A., Ericsson, Maria and Croker, Ben A.
(2018).
Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl.
Blood, 132.
WASHINGTON:
AMER SOC HEMATOLOGY.
ISSN 1528-0020
D'Cruz, Akshay A., Speir, Mary ORCID: 0000-0003-0384-886X, Bliss-Moreau, Meghan, Dietrich, Sylvia, Wang, Shu, Chen, Alyce A., Gavillet, Mathilde, Al-Obeidi, Arshed, Lawlor, Kate E., Vince, James E., Kelliher, Michelle A., Hakem, Razq, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Williams, David A., Ericsson, Maria and Croker, Ben A.
(2018).
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.
Sci. Signal., 11 (546).
WASHINGTON:
AMER ASSOC ADVANCEMENT SCIENCE.
ISSN 1937-9145
Eftychi, Christina, Schwarzer, Robin, Vlantis, Katerina, Wachsmuth, Laurens, Basic, Marijana, Wagle, Prerana, Neurath, Markus F., Becker, Christoph, Bleich, Andre and Pasparakis, Manolis ORCID: 0000-0002-9870-0966
(2019).
Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment.
Immunity, 51 (2).
S. 367 - 385.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4180
Fernandez-Majada, Vanesa, Welz, Patrick-Simon ORCID: 0000-0001-8370-625X, Ermolaeva, Maria A., Schell, Michael, Adam, Alexander, Dietlein, Felix, Komander, David, Buettner, Reinhard, Thomas, Roman K., Schumacher, Bjoern and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2016).
The tumour suppressor CYLD regulates the p53 DNA damage response.
Nat. Commun., 7.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Fritsch, Melanie, Gunther, Saskia D., Schwarzer, Robin, Albert, Marie-Christine, Schorn, Fabian, Werthenbach, J. Paul, Schiffmann, Lars M., Stair, Neil, Stocks, Hannah ORCID: 0000-0002-4129-5138, Seeger, Jens M., Lamkanfi, Mohamed, Kroenke, Martin, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Kashkar, Hamid
(2019).
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Nature, 575 (7784).
S. 683 - 700.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A., Abrams, John M., Adam, Dieter ORCID: 0000-0002-5668-5032, Agostinis, Patrizia
ORCID: 0000-0003-1314-2115, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita
ORCID: 0000-0002-4717-4740, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia
ORCID: 0000-0003-3045-951X, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac
ORCID: 0000-0001-7548-7771, Cecconi, Francesco, Chan, Francis K. -M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus
ORCID: 0000-0003-1140-5612, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D'Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De laurenzi, Vincenzo, De Maria, Ruggero
ORCID: 0000-0003-2255-0583, Debatin, Klaus-Michael
ORCID: 0000-0002-8397-1886, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco
ORCID: 0000-0003-3566-1362, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria
ORCID: 0000-0003-4438-3325, Fulda, Simone
ORCID: 0000-0002-0459-6417, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis
ORCID: 0000-0001-6319-8331, Golstein, Pierre
ORCID: 0000-0003-1750-3483, Gottlieb, Eyal
ORCID: 0000-0002-9770-0956, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich
ORCID: 0000-0001-9454-2449, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jaattela, Marja
ORCID: 0000-0001-5950-7111, Joseph, Bertrand, Jost, Philipp J.
ORCID: 0000-0003-2454-0362, Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas
ORCID: 0000-0001-9906-874X, Kepp, Oliver
ORCID: 0000-0002-6081-9558, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kumar, Sharad
ORCID: 0000-0001-7126-9814, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas
ORCID: 0000-0001-6287-9725, Lipton, Stuart A., Lockshin, Richard A., Lopez-Otin, Carlos
ORCID: 0000-0001-6964-1904, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola
ORCID: 0000-0003-3759-8029, Marine, Jean-Christophe
ORCID: 0000-0003-2433-9837, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal
ORCID: 0000-0003-2760-6523, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Munoz-Pinedo, Cristina
ORCID: 0000-0002-9120-664X, Nagata, Shigekazu
ORCID: 0000-0001-9758-8426, Nunez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Penninger, Josef M., Pereira, David M.
ORCID: 0000-0003-0384-7592, Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro
ORCID: 0000-0003-2919-1296, Pinton, Paolo, Prehn, Jochen H. M., Puthalakath, Hamsa
ORCID: 0000-0001-5178-1175, Rabinovich, Gabriel A., Rehm, Markus
ORCID: 0000-0001-6149-9261, Rizzuto, Rosario, Rodrigues, Cecilia M. P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca
ORCID: 0000-0002-8515-8928, Shao, Feng, Shi, Yufang
ORCID: 0000-0001-8964-319X, Silke, John
ORCID: 0000-0002-7611-5774, Simon, Hans-Uwe
ORCID: 0000-0002-9404-7736, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas
ORCID: 0000-0002-5020-4891, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios
ORCID: 0000-0002-5253-1466, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris
ORCID: 0000-0002-9007-5764, Vanden Berghe, Tom, Vandenabeele, Peter
ORCID: 0000-0002-6669-8822, Heiden, Matthew G. Vander, Villunger, Andreas, Virgin, Herbert W., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning
ORCID: 0000-0002-6312-4591, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris
ORCID: 0000-0002-2238-3482, Zitvogel, Laurence, Melino, Gerry and Kroemer, Guido
(2018).
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Cell Death Differ., 25 (3).
S. 486 - 542.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-5403
Graeb, Jessica, Suarez, Isabelle, van Gumpel, Edeltraud, Winter, Sandra, Schreiber, Fynn, Esser, Anna, Hoelscher, Christoph, Fritsch, Melanie, Herb, Marc ORCID: 0000-0002-7533-0288, Schramm, Michael, Wachsmuth, Laurens, Pallasch, Christian, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Kashkar, Hamid and Rybniker, Jan
(2019).
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.
Nat. Commun., 10.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz ORCID: 0000-0002-1350-2056, Das, Sudeshna
ORCID: 0000-0002-9486-6811, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong
ORCID: 0000-0002-2575-4031, Chen, Hongbo
ORCID: 0000-0002-9084-7277, Mayo, Lior
ORCID: 0000-0002-1296-6692, Geng, Jiefei, Amin, Palak
ORCID: 0000-0001-5617-8703, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Kelliher, Michelle A., Ravits, John and Yuan, Junying
(2016).
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Science, 353 (6299).
S. 603 - 609.
WASHINGTON:
AMER ASSOC ADVANCEMENT SCIENCE.
ISSN 1095-9203
Jaco, Isabel, Annibaldi, Alessandro ORCID: 0000-0002-0346-4340, Lalaoui, Najoua
ORCID: 0000-0002-0165-3324, Wilson, Rebecca, Tenev, Tencho, Laurien, Lucie, Kim, Chun
ORCID: 0000-0001-9497-708X, Jamal, Kunzah, John, Sidonie Wicky, Liccardi, Gianmaria, Chau, Diep, Murphy, James M., Brumatti, Gabriela, Feltham, Rebecca, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Silke, John
ORCID: 0000-0002-7611-5774 and Meier, Pascal
ORCID: 0000-0003-2760-6523
(2017).
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Mol. Cell, 66 (5).
S. 698 - 716.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4164
Jiao, Huipeng, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Lin, Juan, Eren, Remzi Onur, Fisher, Amanda, Lane, Rebecca, Young, George R., Kassiotis, George, Kaiser, William J. and Pasparakis, Manolis ORCID: 0000-0002-9870-0966
(2020).
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Nature, 580 (7803).
S. 391 - 410.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Klemann, Christian ORCID: 0000-0002-5639-8690, Pannicke, Ulrich, Morris-Rosendahl, Deborah J., Vlantis, Katerina, Rizzi, Marta, Uhlig, Holm, Vraetz, Thomas, Speckmann, Carsten
ORCID: 0000-0002-6217-1556, Strahm, Brigitte, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Schwarz, Klaus, Ehl, Stephan and Rohr, Jan C.
(2016).
Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency.
Clin. Immunol., 164.
S. 52 - 57.
SAN DIEGO:
ACADEMIC PRESS INC ELSEVIER SCIENCE.
ISSN 1521-7035
Knittel, Gero, Liedgens, Paul, Korovkina, Darya, Seeger, Jens M., Al-Baldawi, Yussor, Al-Maarri, Mona, Fritz, Christian, Vlantis, Katerina, Bezhanova, Svetlana ORCID: 0000-0001-7336-9210, Scheel, Andreas H., Wolz, Olaf-Oliver, Reimann, Maurice, Moeller, Peter, Lopez, Cristina
ORCID: 0000-0001-6644-1659, Schlesner, Matthias
ORCID: 0000-0002-5896-4086, Lohneis, Philipp, Weber, Alexander N. R., Truemper, Lorenz, Staudt, Louis M., Ortmann, Monika, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Siebert, Reiner, Schmitt, Clemens A., Klatt, Andreas R., Wunderlich, F. Thomas, Schaefer, Stephan C., Persigehl, Thorsten, Montesinos-Rongen, Manuel, Odenthal, Margarete, Buettner, Reinhard, Frenzel, Lukas P., Kashkar, Hamid and Reinhardt, H. Christian
(2016).
B-cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B-cell lymphoma in mice.
Blood, 127 (22).
S. 2732 - 2742.
WASHINGTON:
AMER SOC HEMATOLOGY.
ISSN 1528-0020
Koehler, Ulrike A., Boehm, Friederike, Rolfs, Frank, Egger, Michele, Hornemann, Thorsten, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Weber, Achim and Werner, Sabine
(2016).
NF-kappa B/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma.
J. Hepatol., 64 (1).
S. 94 - 103.
AMSTERDAM:
ELSEVIER SCIENCE BV.
ISSN 1600-0641
Koerbelin, Jakob, Dogbevia, Godwin, Michelfelder, Stefan, Ridder, Dirk A., Hunger, Agnes, Wenzel, Jan, Seismann, Henning, Lampe, Melanie, Bannach, Jacqueline, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Kleinschmidt, Juergen A., Schwaninger, Markus and Trepel, Martin
(2016).
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.
EMBO Mol. Med., 8 (6).
S. 609 - 626.
HOBOKEN:
WILEY-BLACKWELL.
ISSN 1757-4684
Koliaraki, Vasiliki ORCID: 0000-0003-1694-6987, Chalkidi, Niki, Henriques, Ana, Tzaferis, Christos, Polykratis, Apostolos
ORCID: 0000-0001-6720-3302, Waisman, Ari, Muller, Werner
ORCID: 0000-0002-1297-9725, Hackam, David J., Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Kollias, George
(2019).
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.
Cell Reports, 26 (3).
S. 536 - 550.
CAMBRIDGE:
CELL PRESS.
ISSN 2211-1247
Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Kumari, Snehlata, Vlantis, Katerina and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2017).
The interplay of IKK, NF-kappa B and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.
Immunol. Rev., 277 (1).
S. 113 - 128.
HOBOKEN:
WILEY.
ISSN 1600-065X
Kondylis, Vangelis ORCID: 0000-0002-6970-8731 and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2019).
RIP Kinases in Liver Cell Death, Inflammation and Cancer.
Trends Mol. Med, 25 (1).
S. 47 - 64.
OXFORD:
ELSEVIER SCI LTD.
ISSN 1471-499X
Krishna-Subramanian, Santosh, Singer, Stephan, Armaka, Marietta, Banales, Jesus M., Holzer, Kerstin, Schirmacher, Peter, Walczak, Henning ORCID: 0000-0002-6312-4591, Kollias, George, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Kondylis, Vangelis
ORCID: 0000-0002-6970-8731
(2019).
RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.
Cell Death Differ., 26 (12).
S. 2710 - 2727.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-5403
Lalaoui, Najoua ORCID: 0000-0002-0165-3324, Boyden, Steven E., Oda, Hirotsugu, Wood, Geryl M., Stone, Deborah L., Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E., Zaal, Kristien J. M., Hoffmann, Patrycja M., Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D., Kuehn, Hye Sun, Yang, Dan, Anderton, Holly
ORCID: 0000-0003-3913-9686, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B., Gutierrez-Cruz, Gustavo, Ombrello, Amanda K., Pinto-Patarroyo, Gineth P., Kueh, Andrew J., Herold, Marco J., Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I., McKenzie, Mark, Light, Amanda, Barham, Beverly K., Jones, Anne, Romeo, Tina M., Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C., Gross, Andrew J., Shum, Anthony K., Hawkins, Edwin D., Masters, Seth L., Lenardo, Michael J., Boehm, Manfred, Rosenzweig, Sergio D., Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Voss, Anne K., Gadina, Massimo, Kastner, Daniel L. and Silke, John
(2020).
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
Nature, 577 (7788).
S. 103 - 123.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Laurien, Lucie, Nagata, Masahiro, Schuenke, Hannah, Delanghe, Tom, Wiederstein, Janica L., Kumari, Snehlata, Schwarzer, Robin, Corona, Teresa, Krueger, Marcus, Bertrand, Mathieu J. M., Kondylis, Vangelis and Pasparakis, Manolis ORCID: 0000-0002-9870-0966
(2020).
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.
Nat. Commun., 11 (1).
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Lebrun, Astrid, Lo Re, Sandra, Chantry, Mathilde, Carerra, Xavier Izquierdo, Uwambayinema, Francine, Ricci, Doriana, Devosse, Raynal, Ibouraadaten, Saloua, Brombin, Lisa, Palmai-Pallag, Mihaly, Yakoub, Yousof, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Lison, Dominique
ORCID: 0000-0001-6557-2518 and Huaux, Francois
(2017).
CCR2(+) monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-1.
J. Pathol., 243 (3).
S. 320 - 331.
HOBOKEN:
WILEY.
ISSN 1096-9896
Liccardi, Gianmaria, Garcia, Laura Ramos, Tenev, Tencho, Annibaldi, Alessandro ORCID: 0000-0002-0346-4340, Legrand, Arnaud J., Robertson, David, Feltham, Rebecca, Anderton, Holly
ORCID: 0000-0003-3913-9686, Darding, Maurice, Peltzer, Nieves
ORCID: 0000-0002-4134-5852, Dannappel, Marius, Schunke, Hannah, Fava, Luca L., Haschka, Manuel D., Glatter, Timo, Nesvizhskii, Alexey, Schmidt, Alexander, Harris, Philip A., Bertin, John, Gough, Peter J., Villunger, Andreas, Silke, John
ORCID: 0000-0002-7611-5774, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Bianchi, Katiuscia and Meier, Pascal
ORCID: 0000-0003-2760-6523
(2019).
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Mol. Cell, 73 (3).
S. 413 - 436.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4164
Lin, Juan, Kumari, Snehlata, Kim, Chun ORCID: 0000-0001-9497-708X, Van, Trieu-My, Wachsmuth, Laurens, Polykratis, Apostolos
ORCID: 0000-0001-6720-3302 and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2016).
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Nature, 540 (7631).
S. 124 - 137.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
MacVicar, Thomas, Ohba, Yohsuke, Nolte, Hendrik, Mayer, Fiona Carola, Tatsuta, Takashi, Sprenger, Hans-Georg, Lindner, Barbara, Zhao, Yue, Li, Jiahui, Bruns, Christiane, Krueger, Marcus, Habich, Markus, Riemer, Jan, Schwarzer, Robin, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Henschke, Sinika, Bruening, Jens C., Zamboni, Nicola
ORCID: 0000-0003-1271-1021 and Langer, Thomas
(2019).
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.
Nature, 575 (7782).
S. 361 - 386.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Naito, Masanori Gomi, Xu, Daichao, Amin, Palak ORCID: 0000-0001-5617-8703, Lee, Jinwoo, Wang, Huibing, Li, Wanjin, Kelliher, Michelle, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Yuan, Junying
ORCID: 0000-0003-2405-6036
(2020).
Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.
Proc. Natl. Acad. Sci. U. S. A., 117 (9).
S. 4959 - 4971.
WASHINGTON:
NATL ACAD SCIENCES.
ISSN 0027-8424
Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander and Degterev, Alexei
(2016).
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.
Immunity, 45 (1).
S. 46 - 60.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4180
O'Donnell, Joanne, Roderick, Justine E., Pasparakis, Manolis and Kelliher, Michelle (2016). IFN gamma-Induced Necroptosis Contributes to Hematopoietic Stem and Progenitor Cell Death and Bone Marrow Failure. Blood, 128 (22). WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020
O'Donnell, Joanne A., Lehman, Jesse, Roderick, Justine E., Martinez-Marin, Dalia ORCID: 0000-0002-5476-4618, Zelic, Matija, Doran, Ciara, Hermance, Nicole, Lyle, Stephen, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Fitzgerald, Katherine A., Marshak-Rothstein, Ann and Kelliher, Michelle A.
(2018).
Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
J. Immunol., 200 (2).
S. 737 - 749.
BETHESDA:
AMER ASSOC IMMUNOLOGISTS.
ISSN 1550-6606
Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kelliher, Michelle
(2018).
Connecting immune deficiency and inflammation.
Science, 361 (6404).
S. 756 - 758.
WASHINGTON:
AMER ASSOC ADVANCEMENT SCIENCE.
ISSN 1095-9203
Pedragosa, Jordi, Miro-Mur, Francesc, Otxoa-de-Amezaga, Amaia, Justicia, Carles, Ruiz-Jaen, Francisca, Ponsaerts, Peter ORCID: 0000-0002-1892-6499, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Planas, Anna M.
(2020).
CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice.
J. Cereb. Blood Flow Metab., 40 (1_SUPPL).
S. S98 - 19.
THOUSAND OAKS:
SAGE PUBLICATIONS INC.
ISSN 1559-7016
Priem, Dario ORCID: 0000-0002-2527-1101, Devos, Michael
ORCID: 0000-0001-9522-6026, Druwe, Sarah, Martens, Arne, Slowicka, Karolina, Ting, Adrian T., Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Declerq, Wim, Vandenabeele, Peter, van Loo, Geert and Bertrand, Mathieu J. M.
(2019).
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms.
Cell Death Dis., 10.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-4889
Reale, Carla ORCID: 0000-0001-7682-4784, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista
ORCID: 0000-0003-3469-8614, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Vito, Pasquale and Stilo, Romania
(2016).
NF-B Essential Modulator (NEMO) Is Critical for Thyroid Function.
J. Biol. Chem., 291 (11).
S. 5765 - 5774.
BETHESDA:
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC.
ISSN 1083-351X
Saleh, Danish, Najjar, Malek, Zelic, Matija, Shah, Saumil, Nogusa, Shoko, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Paczosa, Michelle K., Gough, Peter J., Bertin, John, Whalen, Michael, Fitzgerald, Katherine A., Slavov, Nikolai
ORCID: 0000-0003-2035-1820, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Balachandran, Siddharth, Kelliher, Michelle, Mecsas, Joan and Degterev, Alexei
(2017).
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-beta Synthesis Induced by Lipopolysaccharide.
J. Immunol., 198 (11).
S. 4435 - 4448.
BETHESDA:
AMER ASSOC IMMUNOLOGISTS.
ISSN 1550-6606
Schwarzer, Robin, Jiao, Huipeng, Wachsmuth, Laurens, Tresch, Achim and Pasparakis, Manolis ORCID: 0000-0002-9870-0966
(2020).
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Immunity, 52.
Schwarzer, Robin, Laurien, Lucie and Pasparakis, Manolis
(2020).
New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8.
Current Opinion in Cell Biology, 63.
pp. 186-193.
ISSN 09550674
Strilic, Boris, Yang, Lida, Albarran-Juarez, Julian, Wachsmuth, Laurens, Han, Kang, Mueller, Ulrike C., Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Offermanns, Stefan
ORCID: 0000-0001-8676-6805
(2016).
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Nature, 536 (7615).
S. 215 - 235.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Taraborrelli, Lucia, Peltzer, Nieves ORCID: 0000-0002-4134-5852, Montinaro, Antonella, Kupka, Sebastian, Rieser, Eva, Hartwig, Torsten, Sarr, Aida, Darding, Maurice, Draber, Peter
ORCID: 0000-0001-8658-4614, Haas, Tobias L., Akarca, Ayse, Marafioti, Teresa
ORCID: 0000-0003-1223-6275, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Bertin, John, Gough, Peter J., Bouillet, Philippe
ORCID: 0000-0002-9012-6058, Strasser, Andreas
ORCID: 0000-0002-5020-4891, Leverkus, Martin, Silke, John
ORCID: 0000-0002-7611-5774 and Walczak, Henning
ORCID: 0000-0002-6312-4591
(2018).
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Nat. Commun., 9.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 2041-1723
Torgovnick, Alessandro, Heger, Jan Michel, Liaki, Vasiliki, Isensee, Joerg ORCID: 0000-0002-3390-0051, Schmitt, Anna, Knittel, Gero, Riabinska, Arina, Beleggia, Filippo
ORCID: 0000-0003-0234-7094, Laurien, Lucie, Leeser, Uschi, Juengst, Christian, Siedek, Florian, Vogel, Wenzel, Kluemper, Niklas, Nolte, Hendrik, Wittersheim, Maike, Tharun, Lars, Castiglione, Roberta
ORCID: 0000-0002-9828-4405, Krueger, Marcus, Schauss, Astrid, Perner, Sven, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Buettner, Reinhard, Persigehl, Thorsten, Hucho, Tim, Herter-Sprie, Grit Sophie, Schumacher, Bjoern and Reinhardt, Hans Christian
(2018).
The Cdkn1a(SuPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression.
Cell Reports, 25 (4).
S. 1027 - 1046.
CAMBRIDGE:
CELL PRESS.
ISSN 2211-1247
Van, Trieu-My, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Straub, Beate Katharina, Kondylis, Vangelis
ORCID: 0000-0002-6970-8731, Papadopoulou, Nikoletta and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2017).
Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis.
J. Clin. Invest., 127 (7).
S. 2662 - 2678.
ANN ARBOR:
AMER SOC CLINICAL INVESTIGATION INC.
ISSN 1558-8238
Verboom, Lien, Martens, Arne, Priem, Dario ORCID: 0000-0002-2527-1101, Hoste, Esther
ORCID: 0000-0002-3181-431X, Sze, Mozes, Vikkula, Hanna, Van Hove, Lisette, Voet, Sofie, Roels, Jana, Maelfait, Jonathan
ORCID: 0000-0002-1476-0583, Bongiovanni, Laura, de Bruin, Alain, Scott, Charlotte L., Saeys, Yvan
ORCID: 0000-0002-0415-1506, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Bertrand, Mathieu J. M. and van Loo, Geert
(2020).
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Cell Reports, 30 (7).
S. 2237 - 2248.
CAMBRIDGE:
CELL PRESS.
ISSN 2211-1247
Vlantis, Katerina, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Welz, Patrick-Simon
ORCID: 0000-0001-8370-625X, van Loo, Geert, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966 and Wullaert, Andy
ORCID: 0000-0001-5012-654X
(2016).
TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.
Gut, 65 (6).
S. 935 - 944.
LONDON:
BMJ PUBLISHING GROUP.
ISSN 1468-3288
Vlantis, Katerina, Wullaert, Andy ORCID: 0000-0001-5012-654X, Polykratis, Apostolos
ORCID: 0000-0001-6720-3302, Kondylis, Vangelis
ORCID: 0000-0002-6970-8731, Dannappel, Marius, Schwarzer, Robin, Welz, Patrick, Corona, Teresa, Walczak, Henning
ORCID: 0000-0002-6312-4591, Weih, Falk, Klein, Ulf, Kelliher, Michelle and Pasparakis, Manolis
ORCID: 0000-0002-9870-0966
(2016).
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappa B-Dependent and -Independent Functions.
Immunity, 44 (3).
S. 553 - 568.
CAMBRIDGE:
CELL PRESS.
ISSN 1097-4180
Vreka, Malamati, Lilis, Ioannis, Papageorgopoulou, Maria, Giotopoulou, Georgia A., Lianou, Marina, Giopanou, Ioanna ORCID: 0000-0003-4393-7517, Kanellakis, Nikolaos I., Spella, Magda, Agalioti, Theodora
ORCID: 0000-0002-5898-2751, Armenis, Vasileios, Goldmann, Torsten
ORCID: 0000-0002-1621-560X, Marwitz, Sebastian
ORCID: 0000-0003-4920-5552, Yull, Fiona E., Blackwell, Timothy S., Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Marazioti, Antonia and Stathopoulos, Georgios T.
(2018).
I kappa B Kinase alpha Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma.
Cancer Res., 78 (11).
S. 2939 - 2952.
PHILADELPHIA:
AMER ASSOC CANCER RESEARCH.
ISSN 1538-7445
Wong, Jerry, Garcia-Carbonell, Ricard, Zelic, Matija, Ho, Samuel B., Boland, Brigid S., Yao, Shih-Jing, Desai, Shalin A., Das, Soumita, Planell, Nuria, Harris, Philip A., Font-Burgada, Joan, Taniguchi, Koji, Bertin, John, Salas, Azucena, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Gough, Pete J., Kelliher, Michelle, Karin, Michael and Guma, Monica
(2020).
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-kappa B Activation.
Cell. Mol. Gastroenterol. Hepatol., 9 (2).
S. 295 - 313.
SAN DIEGO:
ELSEVIER INC.
ISSN 2352-345X
Wroblewski, Raluca, Armaka, Marietta, Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Pasparakis, Manolis
ORCID: 0000-0002-9870-0966, Walczak, Henning
ORCID: 0000-0002-6312-4591, Mittruecker, Hans-Willi, Schramm, Christoph, Lohse, Ansgar W., Kollias, George
ORCID: 0000-0003-1867-3150 and Ehlken, Hanno
(2016).
Opposing Role of Tumor Necrosis Factor Receptor 1 Signaling in T Cell-Mediated Hepatitis and Bacterial Infection in Mice.
Hepatology, 64 (2).
S. 508 - 522.
HOBOKEN:
WILEY-BLACKWELL.
ISSN 1527-3350
Zelic, Matija, Roderick, Justine E., O'Donnell, Joanne A., Lehman, Jesse, Lim, Sung Eun, Janardhan, Harish P., Trivedi, Chinmay M., Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kelliher, Michelle A.
(2018).
RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome.
J. Clin. Invest., 128 (5).
S. 2064 - 2076.
ANN ARBOR:
AMER SOC CLINICAL INVESTIGATION INC.
ISSN 1558-8238
Book Section, Proceedings Item or annotation in a legal commentary
Kumari, Snehlata and Pasparakis, Manolis ORCID: 0000-0002-9870-0966
(2017).
Epithelial Cell Death and Inflammation in Skin.
In:
Current Topics in Microbiology and Immunology,
S. 77 - 94.
BERLIN:
SPRINGER-VERLAG BERLIN.
ISBN 978-3-319-23913-2; 978-3-319-23912-5