Universität zu Köln

Journal Article

Aden, Konrad ORCID: 0000-0003-3482-7316, Tran, Florian, Ito, Go, Sheibani-Tezerji, Raheleh, Lipinski, Simone, Kuiper, Jan W., Tschurtschenthaler, Markus ORCID: 0000-0002-0060-4790, Saveljeva, Svetlana, Bhattacharyya, Joya ORCID: 0000-0003-1745-4167, Haesler, Robert, Bartsch, Kareen, Luzius, Anne, Jentzsch, Marlene, Falk-Paulsen, Maren, Stengel, Stephanie T., Welz, Lina, Schwarzer, Robin, Rabe, Bjoern, Barchet, Winfried ORCID: 0000-0002-6745-6606, Krautwald, Stefan ORCID: 0000-0001-7768-2132, Hartmann, Gunther ORCID: 0000-0003-1021-2018, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Blumberg, Richard S., Schreiber, Stefan, Kaser, Arthur and Rosenstiel, Philip ORCID: 0000-0002-9692-8828 (2018). ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J. Exp. Med., 215 (11). S. 2868 - 2887. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-9538

Androulidaki, Ariadne, Wachsmuth, Laurens, Polykratis, Apostolos ORCID: 0000-0001-6720-3302 and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2018). Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes. PLoS One, 13 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Armaka, Marietta, Ospelt, Caroline ORCID: 0000-0002-9151-4650, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kollias, George (2018). The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

D'Cruz, Akshay A., Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Chen, Alyce A., Gavillet, Mathilde, Lawlor, Kate E., Vince, James E., Kelliher, Michelle, Hakem, Razq, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Williams, David A., Ericsson, Maria and Croker, Ben A. (2018). Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl. Blood, 132. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

D'Cruz, Akshay A., Speir, Mary ORCID: 0000-0003-0384-886X, Bliss-Moreau, Meghan, Dietrich, Sylvia, Wang, Shu, Chen, Alyce A., Gavillet, Mathilde, Al-Obeidi, Arshed, Lawlor, Kate E., Vince, James E., Kelliher, Michelle A., Hakem, Razq, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Williams, David A., Ericsson, Maria and Croker, Ben A. (2018). The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Sci. Signal., 11 (546). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1937-9145

Eftychi, Christina, Schwarzer, Robin, Vlantis, Katerina, Wachsmuth, Laurens, Basic, Marijana, Wagle, Prerana, Neurath, Markus F., Becker, Christoph, Bleich, Andre and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2019). Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. Immunity, 51 (2). S. 367 - 385. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

Fernandez-Majada, Vanesa, Welz, Patrick-Simon ORCID: 0000-0001-8370-625X, Ermolaeva, Maria A., Schell, Michael, Adam, Alexander, Dietlein, Felix, Komander, David, Buettner, Reinhard, Thomas, Roman K., Schumacher, Bjoern and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2016). The tumour suppressor CYLD regulates the p53 DNA damage response. Nat. Commun., 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Fritsch, Melanie, Gunther, Saskia D., Schwarzer, Robin, Albert, Marie-Christine, Schorn, Fabian, Werthenbach, J. Paul, Schiffmann, Lars M., Stair, Neil, Stocks, Hannah ORCID: 0000-0002-4129-5138, Seeger, Jens M., Lamkanfi, Mohamed, Kroenke, Martin, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kashkar, Hamid (2019). Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis. Nature, 575 (7784). S. 683 - 700. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A., Abrams, John M., Adam, Dieter ORCID: 0000-0002-5668-5032, Agostinis, Patrizia ORCID: 0000-0003-1314-2115, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita ORCID: 0000-0002-4717-4740, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia ORCID: 0000-0003-3045-951X, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac ORCID: 0000-0001-7548-7771, Cecconi, Francesco, Chan, Francis K. -M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus ORCID: 0000-0003-1140-5612, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D'Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De laurenzi, Vincenzo, De Maria, Ruggero ORCID: 0000-0003-2255-0583, Debatin, Klaus-Michael ORCID: 0000-0002-8397-1886, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco ORCID: 0000-0003-3566-1362, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria ORCID: 0000-0003-4438-3325, Fulda, Simone ORCID: 0000-0002-0459-6417, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis ORCID: 0000-0001-6319-8331, Golstein, Pierre ORCID: 0000-0003-1750-3483, Gottlieb, Eyal ORCID: 0000-0002-9770-0956, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich ORCID: 0000-0001-9454-2449, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jaattela, Marja ORCID: 0000-0001-5950-7111, Joseph, Bertrand, Jost, Philipp J. ORCID: 0000-0003-2454-0362, Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas ORCID: 0000-0001-9906-874X, Kepp, Oliver ORCID: 0000-0002-6081-9558, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kumar, Sharad ORCID: 0000-0001-7126-9814, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas ORCID: 0000-0001-6287-9725, Lipton, Stuart A., Lockshin, Richard A., Lopez-Otin, Carlos ORCID: 0000-0001-6964-1904, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola ORCID: 0000-0003-3759-8029, Marine, Jean-Christophe ORCID: 0000-0003-2433-9837, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal ORCID: 0000-0003-2760-6523, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Munoz-Pinedo, Cristina ORCID: 0000-0002-9120-664X, Nagata, Shigekazu ORCID: 0000-0001-9758-8426, Nunez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Penninger, Josef M., Pereira, David M. ORCID: 0000-0003-0384-7592, Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro ORCID: 0000-0003-2919-1296, Pinton, Paolo, Prehn, Jochen H. M., Puthalakath, Hamsa ORCID: 0000-0001-5178-1175, Rabinovich, Gabriel A., Rehm, Markus ORCID: 0000-0001-6149-9261, Rizzuto, Rosario, Rodrigues, Cecilia M. P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca ORCID: 0000-0002-8515-8928, Shao, Feng, Shi, Yufang ORCID: 0000-0001-8964-319X, Silke, John ORCID: 0000-0002-7611-5774, Simon, Hans-Uwe ORCID: 0000-0002-9404-7736, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas ORCID: 0000-0002-5020-4891, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios ORCID: 0000-0002-5253-1466, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris ORCID: 0000-0002-9007-5764, Vanden Berghe, Tom, Vandenabeele, Peter ORCID: 0000-0002-6669-8822, Heiden, Matthew G. Vander, Villunger, Andreas, Virgin, Herbert W., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning ORCID: 0000-0002-6312-4591, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris ORCID: 0000-0002-2238-3482, Zitvogel, Laurence, Melino, Gerry and Kroemer, Guido (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ., 25 (3). S. 486 - 542. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5403

Graeb, Jessica, Suarez, Isabelle, van Gumpel, Edeltraud, Winter, Sandra, Schreiber, Fynn, Esser, Anna, Hoelscher, Christoph, Fritsch, Melanie, Herb, Marc ORCID: 0000-0002-7533-0288, Schramm, Michael, Wachsmuth, Laurens, Pallasch, Christian, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Kashkar, Hamid and Rybniker, Jan (2019). Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz ORCID: 0000-0002-1350-2056, Das, Sudeshna ORCID: 0000-0002-9486-6811, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong ORCID: 0000-0002-2575-4031, Chen, Hongbo ORCID: 0000-0002-9084-7277, Mayo, Lior ORCID: 0000-0002-1296-6692, Geng, Jiefei, Amin, Palak ORCID: 0000-0001-5617-8703, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jian-bing, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Kelliher, Michelle A., Ravits, John and Yuan, Junying (2016). RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science, 353 (6299). S. 603 - 609. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

Jaco, Isabel, Annibaldi, Alessandro ORCID: 0000-0002-0346-4340, Lalaoui, Najoua ORCID: 0000-0002-0165-3324, Wilson, Rebecca, Tenev, Tencho, Laurien, Lucie, Kim, Chun ORCID: 0000-0001-9497-708X, Jamal, Kunzah, John, Sidonie Wicky, Liccardi, Gianmaria, Chau, Diep, Murphy, James M., Brumatti, Gabriela, Feltham, Rebecca, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Silke, John ORCID: 0000-0002-7611-5774 and Meier, Pascal ORCID: 0000-0003-2760-6523 (2017). MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol. Cell, 66 (5). S. 698 - 716. CAMBRIDGE: CELL PRESS. ISSN 1097-4164

Jiao, Huipeng, Wachsmuth, Laurens, Kumari, Snehlata, Schwarzer, Robin, Lin, Juan, Eren, Remzi Onur, Fisher, Amanda, Lane, Rebecca, Young, George R., Kassiotis, George, Kaiser, William J. and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2020). Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature, 580 (7803). S. 391 - 410. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Klemann, Christian ORCID: 0000-0002-5639-8690, Pannicke, Ulrich, Morris-Rosendahl, Deborah J., Vlantis, Katerina, Rizzi, Marta, Uhlig, Holm, Vraetz, Thomas, Speckmann, Carsten ORCID: 0000-0002-6217-1556, Strahm, Brigitte, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Schwarz, Klaus, Ehl, Stephan and Rohr, Jan C. (2016). Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency. Clin. Immunol., 164. S. 52 - 57. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

Knittel, Gero, Liedgens, Paul, Korovkina, Darya, Seeger, Jens M., Al-Baldawi, Yussor, Al-Maarri, Mona, Fritz, Christian, Vlantis, Katerina, Bezhanova, Svetlana ORCID: 0000-0001-7336-9210, Scheel, Andreas H., Wolz, Olaf-Oliver, Reimann, Maurice, Moeller, Peter, Lopez, Cristina ORCID: 0000-0001-6644-1659, Schlesner, Matthias ORCID: 0000-0002-5896-4086, Lohneis, Philipp, Weber, Alexander N. R., Truemper, Lorenz, Staudt, Louis M., Ortmann, Monika, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Siebert, Reiner, Schmitt, Clemens A., Klatt, Andreas R., Wunderlich, F. Thomas, Schaefer, Stephan C., Persigehl, Thorsten, Montesinos-Rongen, Manuel, Odenthal, Margarete, Buettner, Reinhard, Frenzel, Lukas P., Kashkar, Hamid and Reinhardt, H. Christian (2016). B-cell-specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B-cell lymphoma in mice. Blood, 127 (22). S. 2732 - 2742. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

Koehler, Ulrike A., Boehm, Friederike, Rolfs, Frank, Egger, Michele, Hornemann, Thorsten, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Weber, Achim and Werner, Sabine (2016). NF-kappa B/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J. Hepatol., 64 (1). S. 94 - 103. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1600-0641

Koerbelin, Jakob, Dogbevia, Godwin, Michelfelder, Stefan, Ridder, Dirk A., Hunger, Agnes, Wenzel, Jan, Seismann, Henning, Lampe, Melanie, Bannach, Jacqueline, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Kleinschmidt, Juergen A., Schwaninger, Markus and Trepel, Martin (2016). A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol. Med., 8 (6). S. 609 - 626. HOBOKEN: WILEY-BLACKWELL. ISSN 1757-4684

Koliaraki, Vasiliki ORCID: 0000-0003-1694-6987, Chalkidi, Niki, Henriques, Ana, Tzaferis, Christos, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Waisman, Ari, Muller, Werner ORCID: 0000-0002-1297-9725, Hackam, David J., Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kollias, George (2019). Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis. Cell Reports, 26 (3). S. 536 - 550. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Kumari, Snehlata, Vlantis, Katerina and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2017). The interplay of IKK, NF-kappa B and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunol. Rev., 277 (1). S. 113 - 128. HOBOKEN: WILEY. ISSN 1600-065X

Kondylis, Vangelis ORCID: 0000-0002-6970-8731 and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2019). RIP Kinases in Liver Cell Death, Inflammation and Cancer. Trends Mol. Med, 25 (1). S. 47 - 64. OXFORD: ELSEVIER SCI LTD. ISSN 1471-499X

Krishna-Subramanian, Santosh, Singer, Stephan, Armaka, Marietta, Banales, Jesus M., Holzer, Kerstin, Schirmacher, Peter, Walczak, Henning ORCID: 0000-0002-6312-4591, Kollias, George, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kondylis, Vangelis ORCID: 0000-0002-6970-8731 (2019). RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ., 26 (12). S. 2710 - 2727. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5403

Lalaoui, Najoua ORCID: 0000-0002-0165-3324, Boyden, Steven E., Oda, Hirotsugu, Wood, Geryl M., Stone, Deborah L., Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E., Zaal, Kristien J. M., Hoffmann, Patrycja M., Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D., Kuehn, Hye Sun, Yang, Dan, Anderton, Holly ORCID: 0000-0003-3913-9686, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B., Gutierrez-Cruz, Gustavo, Ombrello, Amanda K., Pinto-Patarroyo, Gineth P., Kueh, Andrew J., Herold, Marco J., Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I., McKenzie, Mark, Light, Amanda, Barham, Beverly K., Jones, Anne, Romeo, Tina M., Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C., Gross, Andrew J., Shum, Anthony K., Hawkins, Edwin D., Masters, Seth L., Lenardo, Michael J., Boehm, Manfred, Rosenzweig, Sergio D., Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Voss, Anne K., Gadina, Massimo, Kastner, Daniel L. and Silke, John (2020). Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature, 577 (7788). S. 103 - 123. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Laurien, Lucie, Nagata, Masahiro, Schuenke, Hannah, Delanghe, Tom, Wiederstein, Janica L., Kumari, Snehlata, Schwarzer, Robin, Corona, Teresa, Krueger, Marcus, Bertrand, Mathieu J. M., Kondylis, Vangelis and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat. Commun., 11 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Lebrun, Astrid, Lo Re, Sandra, Chantry, Mathilde, Carerra, Xavier Izquierdo, Uwambayinema, Francine, Ricci, Doriana, Devosse, Raynal, Ibouraadaten, Saloua, Brombin, Lisa, Palmai-Pallag, Mihaly, Yakoub, Yousof, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Lison, Dominique ORCID: 0000-0001-6557-2518 and Huaux, Francois (2017). CCR2(+) monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-1. J. Pathol., 243 (3). S. 320 - 331. HOBOKEN: WILEY. ISSN 1096-9896

Liccardi, Gianmaria, Garcia, Laura Ramos, Tenev, Tencho, Annibaldi, Alessandro ORCID: 0000-0002-0346-4340, Legrand, Arnaud J., Robertson, David, Feltham, Rebecca, Anderton, Holly ORCID: 0000-0003-3913-9686, Darding, Maurice, Peltzer, Nieves ORCID: 0000-0002-4134-5852, Dannappel, Marius, Schunke, Hannah, Fava, Luca L., Haschka, Manuel D., Glatter, Timo, Nesvizhskii, Alexey, Schmidt, Alexander, Harris, Philip A., Bertin, John, Gough, Peter J., Villunger, Andreas, Silke, John ORCID: 0000-0002-7611-5774, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Bianchi, Katiuscia and Meier, Pascal ORCID: 0000-0003-2760-6523 (2019). RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol. Cell, 73 (3). S. 413 - 436. CAMBRIDGE: CELL PRESS. ISSN 1097-4164

Lin, Juan, Kumari, Snehlata, Kim, Chun ORCID: 0000-0001-9497-708X, Van, Trieu-My, Wachsmuth, Laurens, Polykratis, Apostolos ORCID: 0000-0001-6720-3302 and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540 (7631). S. 124 - 137. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

MacVicar, Thomas, Ohba, Yohsuke, Nolte, Hendrik, Mayer, Fiona Carola, Tatsuta, Takashi, Sprenger, Hans-Georg, Lindner, Barbara, Zhao, Yue, Li, Jiahui, Bruns, Christiane, Krueger, Marcus, Habich, Markus, Riemer, Jan, Schwarzer, Robin, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Henschke, Sinika, Bruening, Jens C., Zamboni, Nicola ORCID: 0000-0003-1271-1021 and Langer, Thomas (2019). Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature, 575 (7782). S. 361 - 386. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Naito, Masanori Gomi, Xu, Daichao, Amin, Palak ORCID: 0000-0001-5617-8703, Lee, Jinwoo, Wang, Huibing, Li, Wanjin, Kelliher, Michelle, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Yuan, Junying ORCID: 0000-0003-2405-6036 (2020). Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc. Natl. Acad. Sci. U. S. A., 117 (9). S. 4959 - 4971. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Najjar, Malek, Saleh, Danish, Zelic, Matija, Nogusa, Shoko, Shah, Saumil, Tai, Albert, Finger, Joshua N., Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Gough, Peter J., Bertin, John, Whalen, Michael J., Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Balachandran, Siddharth, Kelliher, Michelle, Poltorak, Alexander and Degterev, Alexei (2016). RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity, 45 (1). S. 46 - 60. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

O'Donnell, Joanne, Roderick, Justine E., Pasparakis, Manolis and Kelliher, Michelle (2016). IFN gamma-Induced Necroptosis Contributes to Hematopoietic Stem and Progenitor Cell Death and Bone Marrow Failure. Blood, 128 (22). WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

O'Donnell, Joanne A., Lehman, Jesse, Roderick, Justine E., Martinez-Marin, Dalia ORCID: 0000-0002-5476-4618, Zelic, Matija, Doran, Ciara, Hermance, Nicole, Lyle, Stephen, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Fitzgerald, Katherine A., Marshak-Rothstein, Ann and Kelliher, Michelle A. (2018). Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity. J. Immunol., 200 (2). S. 737 - 749. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kelliher, Michelle (2018). Connecting immune deficiency and inflammation. Science, 361 (6404). S. 756 - 758. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

Pedragosa, Jordi, Miro-Mur, Francesc, Otxoa-de-Amezaga, Amaia, Justicia, Carles, Ruiz-Jaen, Francisca, Ponsaerts, Peter ORCID: 0000-0002-1892-6499, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Planas, Anna M. (2020). CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice. J. Cereb. Blood Flow Metab., 40 (1_SUPPL). S. S98 - 19. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1559-7016

Priem, Dario ORCID: 0000-0002-2527-1101, Devos, Michael ORCID: 0000-0001-9522-6026, Druwe, Sarah, Martens, Arne, Slowicka, Karolina, Ting, Adrian T., Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Declerq, Wim, Vandenabeele, Peter, van Loo, Geert and Bertrand, Mathieu J. M. (2019). A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell Death Dis., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-4889

Reale, Carla ORCID: 0000-0001-7682-4784, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista ORCID: 0000-0003-3469-8614, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Vito, Pasquale and Stilo, Romania (2016). NF-B Essential Modulator (NEMO) Is Critical for Thyroid Function. J. Biol. Chem., 291 (11). S. 5765 - 5774. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 1083-351X

Saleh, Danish, Najjar, Malek, Zelic, Matija, Shah, Saumil, Nogusa, Shoko, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Paczosa, Michelle K., Gough, Peter J., Bertin, John, Whalen, Michael, Fitzgerald, Katherine A., Slavov, Nikolai ORCID: 0000-0003-2035-1820, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Balachandran, Siddharth, Kelliher, Michelle, Mecsas, Joan and Degterev, Alexei (2017). Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-beta Synthesis Induced by Lipopolysaccharide. J. Immunol., 198 (11). S. 4435 - 4448. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

Schwarzer, Robin, Jiao, Huipeng, Wachsmuth, Laurens, Tresch, Achim and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity, 52.

Schwarzer, Robin, Laurien, Lucie and Pasparakis, Manolis (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Current Opinion in Cell Biology, 63. pp. 186-193. ISSN 09550674

Strilic, Boris, Yang, Lida, Albarran-Juarez, Julian, Wachsmuth, Laurens, Han, Kang, Mueller, Ulrike C., Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Offermanns, Stefan ORCID: 0000-0001-8676-6805 (2016). Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature, 536 (7615). S. 215 - 235. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Taraborrelli, Lucia, Peltzer, Nieves ORCID: 0000-0002-4134-5852, Montinaro, Antonella, Kupka, Sebastian, Rieser, Eva, Hartwig, Torsten, Sarr, Aida, Darding, Maurice, Draber, Peter ORCID: 0000-0001-8658-4614, Haas, Tobias L., Akarca, Ayse, Marafioti, Teresa ORCID: 0000-0003-1223-6275, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Bertin, John, Gough, Peter J., Bouillet, Philippe ORCID: 0000-0002-9012-6058, Strasser, Andreas ORCID: 0000-0002-5020-4891, Leverkus, Martin, Silke, John ORCID: 0000-0002-7611-5774 and Walczak, Henning ORCID: 0000-0002-6312-4591 (2018). LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Torgovnick, Alessandro, Heger, Jan Michel, Liaki, Vasiliki, Isensee, Joerg ORCID: 0000-0002-3390-0051, Schmitt, Anna, Knittel, Gero, Riabinska, Arina, Beleggia, Filippo ORCID: 0000-0003-0234-7094, Laurien, Lucie, Leeser, Uschi, Juengst, Christian, Siedek, Florian, Vogel, Wenzel, Kluemper, Niklas, Nolte, Hendrik, Wittersheim, Maike, Tharun, Lars, Castiglione, Roberta ORCID: 0000-0002-9828-4405, Krueger, Marcus, Schauss, Astrid, Perner, Sven, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Buettner, Reinhard, Persigehl, Thorsten, Hucho, Tim, Herter-Sprie, Grit Sophie, Schumacher, Bjoern and Reinhardt, Hans Christian (2018). The Cdkn1a(SuPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Reports, 25 (4). S. 1027 - 1046. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Van, Trieu-My, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Straub, Beate Katharina, Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Papadopoulou, Nikoletta and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2017). Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J. Clin. Invest., 127 (7). S. 2662 - 2678. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

Verboom, Lien, Martens, Arne, Priem, Dario ORCID: 0000-0002-2527-1101, Hoste, Esther ORCID: 0000-0002-3181-431X, Sze, Mozes, Vikkula, Hanna, Van Hove, Lisette, Voet, Sofie, Roels, Jana, Maelfait, Jonathan ORCID: 0000-0002-1476-0583, Bongiovanni, Laura, de Bruin, Alain, Scott, Charlotte L., Saeys, Yvan ORCID: 0000-0002-0415-1506, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Bertrand, Mathieu J. M. and van Loo, Geert (2020). OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Reports, 30 (7). S. 2237 - 2248. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Vlantis, Katerina, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Welz, Patrick-Simon ORCID: 0000-0001-8370-625X, van Loo, Geert, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Wullaert, Andy ORCID: 0000-0001-5012-654X (2016). TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut, 65 (6). S. 935 - 944. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3288

Vlantis, Katerina, Wullaert, Andy ORCID: 0000-0001-5012-654X, Polykratis, Apostolos ORCID: 0000-0001-6720-3302, Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Dannappel, Marius, Schwarzer, Robin, Welz, Patrick, Corona, Teresa, Walczak, Henning ORCID: 0000-0002-6312-4591, Weih, Falk, Klein, Ulf, Kelliher, Michelle and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2016). NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappa B-Dependent and -Independent Functions. Immunity, 44 (3). S. 553 - 568. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

Vreka, Malamati, Lilis, Ioannis, Papageorgopoulou, Maria, Giotopoulou, Georgia A., Lianou, Marina, Giopanou, Ioanna ORCID: 0000-0003-4393-7517, Kanellakis, Nikolaos I., Spella, Magda, Agalioti, Theodora ORCID: 0000-0002-5898-2751, Armenis, Vasileios, Goldmann, Torsten ORCID: 0000-0002-1621-560X, Marwitz, Sebastian ORCID: 0000-0003-4920-5552, Yull, Fiona E., Blackwell, Timothy S., Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Marazioti, Antonia and Stathopoulos, Georgios T. (2018). I kappa B Kinase alpha Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. Cancer Res., 78 (11). S. 2939 - 2952. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Wong, Jerry, Garcia-Carbonell, Ricard, Zelic, Matija, Ho, Samuel B., Boland, Brigid S., Yao, Shih-Jing, Desai, Shalin A., Das, Soumita, Planell, Nuria, Harris, Philip A., Font-Burgada, Joan, Taniguchi, Koji, Bertin, John, Salas, Azucena, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Gough, Pete J., Kelliher, Michelle, Karin, Michael and Guma, Monica (2020). RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-kappa B Activation. Cell. Mol. Gastroenterol. Hepatol., 9 (2). S. 295 - 313. SAN DIEGO: ELSEVIER INC. ISSN 2352-345X

Wroblewski, Raluca, Armaka, Marietta, Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Walczak, Henning ORCID: 0000-0002-6312-4591, Mittruecker, Hans-Willi, Schramm, Christoph, Lohse, Ansgar W., Kollias, George ORCID: 0000-0003-1867-3150 and Ehlken, Hanno (2016). Opposing Role of Tumor Necrosis Factor Receptor 1 Signaling in T Cell-Mediated Hepatitis and Bacterial Infection in Mice. Hepatology, 64 (2). S. 508 - 522. HOBOKEN: WILEY-BLACKWELL. ISSN 1527-3350

Zelic, Matija, Roderick, Justine E., O'Donnell, Joanne A., Lehman, Jesse, Lim, Sung Eun, Janardhan, Harish P., Trivedi, Chinmay M., Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Kelliher, Michelle A. (2018). RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome. J. Clin. Invest., 128 (5). S. 2064 - 2076. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

Book Section, Proceedings Item or annotation in a legal commentary

Kumari, Snehlata and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2017). Epithelial Cell Death and Inflammation in Skin. In: Current Topics in Microbiology and Immunology, S. 77 - 94. BERLIN: SPRINGER-VERLAG BERLIN. ISBN 978-3-319-23913-2; 978-3-319-23912-5