Universität zu Köln

Thelen, Martin Andreas ORCID: 0000-0002-2785-9726 (2023). Endogenous antigen-specific T and B cell immune responses in cancer and invasive infections are frequent, but often limited by potentially targetable immune escape mechanisms. PhD thesis, Universität zu Köln.

Thelen, Martin ORCID: 0000-0002-2785-9726, Keller, Diandra, Lehmann, Jonas, Wennhold, Kerstin, Weitz, Hendrik, Bauer, Eugen, Gathof, Birgit, Brueggemann, Monika, Kotrova, Michaela, Quaas, Alexander, Mallmann, Christoph, Chon, Seung-Hun, Hillmer, Axel M., Bruns, Christiane, von Bergwelt-Baildon, Michael, Garcia-Marquez, Maria Alejandra and Schloesser, Hans Anton (2022). Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells. J. Immunother. Cancer, 10 (12). LONDON: BMJ PUBLISHING GROUP. ISSN 2051-1426

Khatamzas, Elham, Mellinghoff, Sibylle C., Thelen, Martin ORCID: 0000-0002-2785-9726, Schloesser, Hans A., Kunz, Wolfgang G., Buerkle, Carolin, Dichtl, Karl ORCID: 0000-0001-5032-8870, Ormanns, Steffen and von Bergwelt-Baildon, Michael (2022). Nivolumab induces long-term remission in a patient with fusariosis. Eur. J. Cancer, 173. S. 91 - 95. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

Datta, Rabi R., Schran, Simon ORCID: 0000-0002-1092-9804, Persa, Oana-Diana, Aguilar, Claire, Thelen, Martin ORCID: 0000-0002-2785-9726, Lehmann, Jonas, Garcia-Marquez, Maria A., Wennhold, Kerstin, Preugszat, Ella, Zentis, Peter ORCID: 0000-0002-6999-132X, Von Bergwelt-Baildon, Michael S., Quaas, Alexander, Bruns, Christiane J., Kurschat, Christine, Mauch, Cornelia, Loeser, Heike, Stippel, Dirk L. and Schloesser, Hans A. (2022). Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance. Clin. Cancer Res., 28 (8). S. 1712 - 1724. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1557-3265

Garcia-Marquez, Maria A., Thelen, Martin ORCID: 0000-0002-2785-9726, Reinke, Sarah, Keller, Diandra, Wennhold, Kerstin, Lehmann, Jonas, Veldman, Johanna ORCID: 0000-0003-4253-0870, Borchmann, Sven ORCID: 0000-0001-6662-6864, Rosenwald, Andreas, Sasse, Stephanie, Diepstra, Arjan ORCID: 0000-0001-9239-1050, Borchmann, Peter, Engert, Andreas, Klapper, Wolfram, Von Bergwelt-Baildon, Michael, Broeckelmann, Paul J. and Schloesser, Hans A. (2022). Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma. Leukemia, 36 (3). S. 760 - 772. LONDON: SPRINGERNATURE. ISSN 1476-5551

Mellinghoff, Sibylle C., Robrecht, Sandra, Mayer, Leonie ORCID: 0000-0001-7102-4358, Weskamm, Leonie M., Dahlke, Christine, Gruell, Henning, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Schloesser, Hans A., Thelen, Martin ORCID: 0000-0002-2785-9726, Fink, Anna-Maria, Fischer, Kirsten, Klein, Florian, Addo, Marylyn M., Eichhorst, Barbara, Hallek, Michael and Langerbeins, Petra (2022). SARS-CoV-2 specific cellular response following COVID-19 vaccination in patients with chronic lymphocytic leukemia. Leukemia, 36 (2). S. 562 - 566. LONDON: SPRINGERNATURE. ISSN 1476-5551

Mellinghoff, Sibylle C., Mayer, Leonie, Robrecht, Sandra, Weskamm, Leonie M., Dahlke, Christine ORCID: 0000-0002-2056-9195, Gruell, Henning, Schlotz, Maike, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Schloesser, Hans A., Thelen, Martin ORCID: 0000-0002-2785-9726, Fink, AnnaMaria, Fischer, Kirsten, Klein, Florian ORCID: 0000-0003-1376-1792, Addo, Marylyn M., Eichhorst, Barbara, Hallek, Michael and Langerbeins, Petra (2022). SARS-CoV-2-specific cellular response following third COVID-19 vaccination in patients with chronic lymphocytic leukemia. Haematologica, 107 (10). S. 2480 - 2485. PAVIA: FERRATA STORTI FOUNDATION. ISSN 1592-8721

Mellinghoff, Sibylle C., Thelen, Martin ORCID: 0000-0002-2785-9726, Bruns, Christiane, Garcia-Marquez, Maria, Hartmann, Pia, Lammertz, Tatjana, Lehmann, Jonas, Nowag, Angela, Stemler, Jannik ORCID: 0000-0001-9152-2469, Wennhold, Kerstin, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Von Bergwelt-Baildon, Michael S. and Schloesser, Hans A. (2022). T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option. J. Infect., 84 (2). S. 237 - 248. LONDON: W B SAUNDERS CO LTD. ISSN 1532-2742

Wennhold, Kerstin, Thelen, Martin ORCID: 0000-0002-2785-9726, Lehmann, Jonas, Schran, Simon, Preugszat, Ella, Garcia-Marquez, Maria, Lechner, Axel, Shimabukuro-Vornhagen, Alexander, Ercanoglu, Meryem S., Klein, Florian, Thangarajah, Fabinshy, Eidt, Sebastian, Loeser, Heike, Bruns, Christiane, Quaas, Alexander, von Bergwelt-Baildon, Michael and Schloesser, Hans A. (2021). CD86(+) Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses. Cancer Immunol. Res., 9 (9). S. 1098 - 1109. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2326-6074

Thelen, Martin ORCID: 0000-0002-2785-9726, Wennhold, Kerstin, Lehmann, Jonas, Garcia-Marquez, Maria, Klein, Sebastian ORCID: 0000-0002-2188-9377, Kochen, Elena ORCID: 0000-0003-2470-825X, Lohneis, Philipp, Lechner, Axel, Wagener-Ryczek, Svenja, Plum, Patrick Sven, Velazquez Camacho, Oscar, Pfister, David, Doerr, Fabian, Heldwein, Matthias, Hekmat, Khosro, Beutner, Dirk, Klussmann, Jens Peter, Thangarajah, Fabinshy, Ratiu, Dominik, Malter, Wolfram, Merkelbach-Bruse, Sabine, Bruns, Christiane Josephine, Quaas, Alexander, von Bergwelt-Baildon, Michael and Schloesser, Hans A. (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. npj Precis. Oncol., 5 (1). BERLIN: NATURE RESEARCH. ISSN 2397-768X

Marangoni, Francesco, Zhakyp, Ademi, Corsini, Michela, Geels, Shannon N., Carrizosa, Esteban, Thelen, Martin ORCID: 0000-0002-2785-9726, Mani, Vinidhra, Pruessmann, Jasper N., Warner, Ross D., Ozga, Aleksandra J., Di Pilato, Mauro, Othy, Shivashankar and Mempel, Thorsten R. (2021). Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell, 184 (15). S. 3998 - 4035. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

Banck, Jan Christoph, Mueller, Niklas, Mellinghoff, Sibylle Christiane, Thelen, Martin ORCID: 0000-0002-2785-9726, Fraccaroli, Alessia, Blumenberg, Viktoria, Koehler, Philipp ORCID: 0000-0002-7386-7495, Kunz, Wolfgang Gerhard, Rudelius, Martina, Schroetzlmair, Florian, Subklewe, Marion, Schloesser, Hans Anton, Tischer, Johanna, Cornely, Oliver Andreas, Lindner, Lars Hartwin and von Bergwelt-Baildon, Michael (2021). Immune Checkpoint Blockade for Aspergillosis and Mucormycosis Coinfection. Hemasphere, 5 (3). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2572-9241

Kraemer, Max, Plum, Patrick S. ORCID: 0000-0002-8165-4553, Camacho, Oscar Velazquez, Folz-Donahue, Kat, Thelen, Martin ORCID: 0000-0002-2785-9726, Garcia-Marquez, Isabel, Woelwer, Christina, Buesker, Soeren, Wittig, Jana, Franitza, Marek, Altmueller, Janine, Loeser, Heike, Schloesser, Hans, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane J., Alakus, Hakan, Quaas, Alexander, Chon, Seung-Hun ORCID: 0000-0002-8923-6428 and Hillmer, Axel M. (2020). Cell type-specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics. Mol. Oncol., 14 (6). S. 1170 - 1185. HOBOKEN: WILEY. ISSN 1878-0261

Trub, Marta, Uhlenbrock, Franziska, Claus, Christina, Herzig, Petra, Thelen, Martin ORCID: 0000-0002-2785-9726, Karanikas, Vaios, Bacac, Marina, Amann, Maria, Albrecht, Rosemarie, Ferrara-Koller, Claudia, Thommen, Daniela, Rothschield, Sacha, Prince, Spasenija Savic, Mertz, Kirsten D., Cathomas, Gieri, Rosenberg, Robert, Heinzelmann-Schwarz, Viola, Wiese, Mark, Lardinois, Didier, Umana, Pablo, Klein, Christian ORCID: 0000-0001-7594-7280, Laubli, Heinz, Kashyap, Abhishek S. and Zippelius, Alfred (2020). Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer. J. Immunother. Cancer, 8 (2). LONDON: BMJ PUBLISHING GROUP. ISSN 2051-1426

Wagener-Ryczek, Svenja, Schoemmel, Max, Kraemer, Max, Bruns, Christiane, Schroeder, Wolfgang, Zander, Thomas, Gebauer, Florian, Alakus, Hakan, Merkelbach-Bruse, Sabine, Buettner, Reinhard, Loeser, Heike, Thelen, Martin ORCID: 0000-0002-2785-9726, Schlosser, Hans A. and Quaas, Alexander (2020). Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma. Cancer Immunol. Immunother., 69 (4). S. 523 - 534. NEW YORK: SPRINGER. ISSN 1432-0851

Gebauer, Florian, Kraemer, Max, Bruns, Christiane, Schloesser, Hans A., Thelen, Martin ORCID: 0000-0002-2785-9726, Lohneis, Philipp, Schroeder, Wolfgang, Zander, Thomas, Alakus, Hakan, Buettner, Reinhard, Loeser, Heike and Quaas, Alexander (2020). Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma. J. Cancer Res. Clin. Oncol., 146 (9). S. 2319 - 2328. NEW YORK: SPRINGER. ISSN 1432-1335

Schloesser, Hans A., Thelen, Martin ORCID: 0000-0002-2785-9726, Lechner, Axel, Wennhold, Kerstin, Garcia-Marquez, Maria A., Rothschild, Sacha I., Staib, Elena, Zander, Thomas, Beutner, Dirk, Gathof, Birgit, Gilles, Ramona, Cukuroglu, Engin, Goke, Jonathan ORCID: 0000-0002-0825-4991, Shimabukuro-Vornhagen, Alexander, Drebber, Uta, Quaas, Alexander, Bruns, Christiane J., Hoelscher, Arnulf H. and Von Bergwelt-Baildon, Michael S. (2019). B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies. OncoImmunology, 8 (1). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

Lechner, Axel, Schloesser, Hans A., Thelen, Martin ORCID: 0000-0002-2785-9726, Wennhold, Kerstin, Rothschild, Sacha, I, Gilles, Ramona, Quaas, Alexander, Siefer, Oliver G., Huebbers, Christian U., Cukuroglu, Engin, Goeke, Jonathan, Hillmer, Axel, Gathof, Birgit, Meyer, Moritz F., Klussmann, Jens P., Shimabukuro-Vornhagen, Alexander, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Beutner, Dirk and von Bergwelt-Baildon, Michael (2019). Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma. OncoImmunology, 8 (3). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

Thelen, Martin ORCID: 0000-0002-2785-9726, Lechner, Axel, Wennhold, Kerstin, von Bergwelt-Baildon, Michael and Schloesser, Hans A. (2018). CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8(+) T Cells-Letter. Cancer Res., 78 (17). S. 5173 - 5175. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Meder, Lydia ORCID: 0000-0002-9547-5812, Schuldt, Philipp, Thelen, Martin ORCID: 0000-0002-2785-9726, Schmitt, Anna, Dietlein, Felix, Klein, Sebastian, Borchmann, Sven, Wennhold, Kerstin, Vlasic, Ignacija, Oberbeck, Sebastian, Riedel, Richard, Florin, Alexandra, Golfmann, Kristina, Schloesser, Hans A., Odenthal, Margarete, Buettner, Reinhard, Wolf, Juergen, Hallek, Michael, Herling, Marco, von Bergwelt-Baildon, Michael, Reinhardt, H. Christian and Ullrich, Roland T. (2018). Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer Res., 78 (15). S. 4270 - 4282. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Weber, Tanja M., Klein-Gonzalez, Nela, Thelen, Martin ORCID: 0000-0002-2785-9726, Garcia-Marquez, Maria, Chakupurakal, Geothy, Fiedler, Anne, Schloesser, Hans A., Fischer, Rieke, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Shimabukuro-Vornhagen, Alexander and von Bergwelt-Baildon, Michael (2017). CD40-activated B cells induce anti-tumor immunity in vivo. Oncotarget, 8 (17). S. 27740 - 27754. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Lechner, Axel, Schloesser, Hans, Rothschild, Sacha I., Thelen, Martin ORCID: 0000-0002-2785-9726, Reuter, Sabrina, Zentis, Peter, Shimabukuro-Vornhagen, Alexander, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Garcia-Marquez, Maria, Tharun, Lars, Quaas, Alexander, Schauss, Astrid, Isensee, Joerg ORCID: 0000-0002-3390-0051, Hucho, Tim ORCID: 0000-0002-4147-9308, Huebbers, Christian ORCID: 0000-0002-2934-1218, von Bergwelt-Baildon, Michael and Beutner, Dirk (2017). Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma. Oncotarget, 8 (27). S. 44418 - 44434. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Thelen, Martin ORCID: 0000-0002-2785-9726, Schloesser, Hans Anton, Haustein, Natalie, Reuter, Sabrina, Garcia-Marquez, Maria, Lechner, Axel, Kobold, Sebastian, Rataj, Felicitas, Utermoehlen, Olaf, Chakupurakal, Geothy, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Hallek, Michael, Abken, Hinrich, Shimabukuro-Vornhagen, Alexander and von Bergwelt-Baildon, Michael (2017). Using Antigen-Specific B Cells to Combine Antibody and T Cell-Based Cancer Immunotherapy. Cancer Immunol. Res., 5 (9). S. 730 - 744. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2326-6074

Schloesser, Hans A., Drebber, Uta, Kloth, Michael, Thelen, Martin ORCID: 0000-0002-2785-9726, Rothschild, Sacha I., Haase, Simon, Garcia-Marquez, Maria, Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Berlth, Felix ORCID: 0000-0002-3780-0728, Urbanski, Alexander, Alakus, Hakan, Schauss, Astrid, Shimabukuro-Vornhagen, Alexander, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Warnecke-Ebertz, Ute, Stippel, Dirk L., Zippelius, Alfred, Buettner, Reinhard, Hallek, Michael, Hoelscher, Arnulf H., Zander, Thomas, Moenig, Stefan P. and von Bergwelt-Baildon, Michael (2016). Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma. OncoImmunology, 5 (5). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

Theurich, Sebastian ORCID: 0000-0001-5706-8258, Rothschild, Sacha I., Hoffmann, Michael, Fabri, Mario, Sommer, Andrea, Garcia-Marquez, Maria, Thelen, Martin ORCID: 0000-0002-2785-9726, Schill, Catherine, Merki, Ramona, Schmid, Thomas, Koeberle, Dieter, Zippelius, Alfred, Baues, Christian, Mauch, Cornelia, Tigges, Christian, Kreuter, Alexander, Borggrefe, Jan ORCID: 0000-0003-2908-7560, von Bergwelt-Baildon, Michael and Schlaak, Max (2016). Local Tumor Treatment in Combination with Systemic Ipilimumab Immunotherapy Prolongs Overall Survival in Patients with Advanced Malignant Melanoma. Cancer Immunol. Res., 4 (9). S. 744 - 755. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2326-6074

Wennhold, Kerstin, Thelen, Martin ORCID: 0000-0002-2785-9726, Marquez, Maria Gracia, Scheid, Christof, Shimabukuro-Vornhagen, Alexander and von Bergwelt-Baildon, Michael (2015). Tumorantigen-Specific CD40B Cells: Combining Enhanced Antigen-Presentation and Antibody-Secretion for Tumor Targeting. Blood, 126 (23). WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

Leuchte, Katharina, Staib, Elena, Thelen, Martin ORCID: 0000-0002-2785-9726, Goedel, Philipp, Lechner, Axel, Zentis, Peter, Garcia-Marquez, Maria, Waldschmidt, Dirk, Datta, Rabi Raj, Wahba, Roger, Wybranski, Christian, Zander, Thomas, Quaas, Alexander, Drebber, Uta, Stippel, Dirk Ludger, Bruns, Christiane, Von Bergwelt-Baildon, Michael, Wennhold, Kerstin and Schloesser, Hans Anton . Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma. Cancer Immunol. Immunother.. NEW YORK: SPRINGER. ISSN 1432-0851