Krumbholz, Aniko, Anielski, Patricia, Gfrerer, Lena, Graw, Matthias, Geyer, Hans, Schaenzer, Wilhelm, Dvorak, Jiri and Thieme, Detlef (2014). Statistical significance of hair analysis of clenbuterol to discriminate therapeutic use from contamination. Drug Test. Anal., 6 (11-12). S. 1108 - 1117. HOBOKEN: WILEY. ISSN 1942-7611
Full text not available from this repository.Abstract
Clenbuterol is a well-established 2-agonist, which is prohibited in sports and strictly regulated for use in the livestock industry. During the last few years clenbuterol-positive results in doping controls and in samples from residents or travellers from a high-risk country were suspected to be related the illegal use of clenbuterol for fattening. A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to detect low clenbuterol residues in hair with a detection limit of 0.02pg/mg. A sub-therapeutic application study and a field study with volunteers, who have a high risk of contamination, were performed. For the application study, a total dosage of 30 mu g clenbuterol was applied to 20 healthy volunteers on 5 subsequent days. One month after the beginning of the application, clenbuterol was detected in the proximal hair segment (0-1cm) in concentrations between 0.43 and 4.76pg/mg. For the second part, samples of 66 Mexican soccer players were analyzed. In 89% of these volunteers, clenbuterol was detectable in their hair at concentrations between 0.02 and 1.90pg/mg. A comparison of both parts showed no statistical difference between sub-therapeutic application and contamination. In contrast, discrimination to a typical abuse of clenbuterol is apparently possible. Due to these findings results of real doping control samples can be evaluated. Copyright (c) 2014 John Wiley & Sons, Ltd.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-423937 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1002/dta.1746 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Drug Test. Anal. | ||||||||||||||||||||||||||||||||||||
Volume: | 6 | ||||||||||||||||||||||||||||||||||||
Number: | 11-12 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. 1108 - 1117 | ||||||||||||||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||||||||||||||||||
ISSN: | 1942-7611 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/42393 |
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