Universität zu Köln

Krumbholz, Aniko, Anielski, Patricia, Gfrerer, Lena, Graw, Matthias, Geyer, Hans, Schaenzer, Wilhelm, Dvorak, Jiri and Thieme, Detlef (2014). Statistical significance of hair analysis of clenbuterol to discriminate therapeutic use from contamination. Drug Test. Anal., 6 (11-12). S. 1108 - 1117. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

Clenbuterol is a well-established 2-agonist, which is prohibited in sports and strictly regulated for use in the livestock industry. During the last few years clenbuterol-positive results in doping controls and in samples from residents or travellers from a high-risk country were suspected to be related the illegal use of clenbuterol for fattening. A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to detect low clenbuterol residues in hair with a detection limit of 0.02pg/mg. A sub-therapeutic application study and a field study with volunteers, who have a high risk of contamination, were performed. For the application study, a total dosage of 30 mu g clenbuterol was applied to 20 healthy volunteers on 5 subsequent days. One month after the beginning of the application, clenbuterol was detected in the proximal hair segment (0-1cm) in concentrations between 0.43 and 4.76pg/mg. For the second part, samples of 66 Mexican soccer players were analyzed. In 89% of these volunteers, clenbuterol was detectable in their hair at concentrations between 0.02 and 1.90pg/mg. A comparison of both parts showed no statistical difference between sub-therapeutic application and contamination. In contrast, discrimination to a typical abuse of clenbuterol is apparently possible. Due to these findings results of real doping control samples can be evaluated. Copyright (c) 2014 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krumbholz, Aniko UNSPECIFIED UNSPECIFIED UNSPECIFIED Anielski, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Gfrerer, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Graw, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Dvorak, Jiri UNSPECIFIED UNSPECIFIED UNSPECIFIED Thieme, Detlef UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-423937
DOI:	10.1002/dta.1746
Journal or Publication Title:	Drug Test. Anal.
Volume:	6
Number:	11-12
Page Range:	S. 1108 - 1117
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN SCALP HAIR; FOOD CONTAMINATION; ILLEGAL USE; AGONIST CLENBUTEROL; URINE Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42393