Saiai, Aroonchai, Bielig, Harald, Velder, Janna, Neudoerfl, Joerg-Martin, Menning, Maureen, Kufer, Thomas A. and Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 (2012). Hydrophenalene-Cr(CO)(3) complexes as anti-inflammatory agents based on specific inhibition of NOD2 signalling: a SAR study. MedChemComm, 3 (11). S. 1377 - 1386. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2040-2511
Full text not available from this repository.Abstract
Small molecules, which specifically inhibit NOD2 signalling, are of high interest in the search for new anti-inflammatory drugs. In this context, the previously discovered hydrophenalene-Cr(CO)(3) complex 1 was taken as a lead and new structural analogues were prepared by means of chemical synthesis. The NOD2-inhibiting activity of the compounds was determined with cell-based reporter assays employing human embryonic kidney cells. As a result of the study, some clear structure activity relationships (SARs) could be identified. The best compounds were active at low mu M concentration.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-480614 | ||||||||||||||||||||||||||||||||
DOI: | 10.1039/c2md20221b | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | MedChemComm | ||||||||||||||||||||||||||||||||
Volume: | 3 | ||||||||||||||||||||||||||||||||
Number: | 11 | ||||||||||||||||||||||||||||||||
Page Range: | S. 1377 - 1386 | ||||||||||||||||||||||||||||||||
Date: | 2012 | ||||||||||||||||||||||||||||||||
Publisher: | ROYAL SOC CHEMISTRY | ||||||||||||||||||||||||||||||||
Place of Publication: | CAMBRIDGE | ||||||||||||||||||||||||||||||||
ISSN: | 2040-2511 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/48061 |
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