Saiai, Aroonchai, Bielig, Harald, Velder, Janna, Neudoerfl, Joerg-Martin, Menning, Maureen, Kufer, Thomas A. and Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 (2012). Hydrophenalene-Cr(CO)(3) complexes as anti-inflammatory agents based on specific inhibition of NOD2 signalling: a SAR study. MedChemComm, 3 (11). S. 1377 - 1386. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2040-2511

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Abstract

Small molecules, which specifically inhibit NOD2 signalling, are of high interest in the search for new anti-inflammatory drugs. In this context, the previously discovered hydrophenalene-Cr(CO)(3) complex 1 was taken as a lead and new structural analogues were prepared by means of chemical synthesis. The NOD2-inhibiting activity of the compounds was determined with cell-based reporter assays employing human embryonic kidney cells. As a result of the study, some clear structure activity relationships (SARs) could be identified. The best compounds were active at low mu M concentration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Saiai, AroonchaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bielig, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velder, JannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neudoerfl, Joerg-MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menning, MaureenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kufer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalz, Hans-GuentherUNSPECIFIEDorcid.org/0000-0003-0489-1827UNSPECIFIED
URN: urn:nbn:de:hbz:38-480614
DOI: 10.1039/c2md20221b
Journal or Publication Title: MedChemComm
Volume: 3
Number: 11
Page Range: S. 1377 - 1386
Date: 2012
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 2040-2511
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOLOGICAL EVALUATION; VINYL KETONES; ANNELATIONMultiple languages
Biochemistry & Molecular Biology; Chemistry, MedicinalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48061

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