Universität zu Köln

Mayer, Marcel ORCID: 0000-0001-9963-1109, Kourou, Sofia ORCID: 0009-0000-2277-4160, Alfarra, Marwan, Laatz, Charlotte, Hansen, Kevin ORCID: 0000-0001-5028-0600, Esser, Julia ORCID: 0009-0002-3556-3738, Eckel, Hans Nikolaus Caspar ORCID: 0000-0002-6947-9836, Möllenhoff, Kathrin ORCID: 0000-0001-7861-3892, Hieggelke, Lena ORCID: 0000-0002-1831-0387, Engels, Marianne ORCID: 0009-0003-3805-1380, Arolt, Christoph ORCID: 0000-0002-6366-2285, Quaas, Alexander ORCID: 0000-0002-3537-6011, Wolber, Philipp ORCID: 0000-0001-9019-2840, Jansen, Louis ORCID: 0000-0003-0332-1099, Nachtsheim, Lisa ORCID: 0000-0002-0261-4511, Klussmann, Jens Peter ORCID: 0000-0002-8223-7954 and Shabli, Sami ORCID: 0000-0002-7202-0460 (2026). Fine‐needle aspiration cytology reduces the frequency of surgeries for malignant salivary gland tumors. Cancer Cytopathology, 134 (1). pp. 1-8. Wiley. ISSN 1934-662X

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Abstract

[Artikel-Nr.: e70070] Salivary gland tumors are rare and heterogeneous head and neck neoplasms. Preoperative distinction between benign and malignant lesions is challenging because imaging is often insufficient. Fine‐needle aspiration cytology (FNAC) combined with the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) provides standardized risk stratification and diagnostic guidance; however, its influence on surgical frequency remains insufficiently characterized. The use of the MSRSGC enables reliable preoperative risk stratification of malignant salivary gland tumors. High‐to‐intermediate‐risk categories (Milan III/IVb/V/VI) were associated with a lower likelihood of multiple surgeries. True–positive FNAC results were most frequent in squamous cell carcinoma and metastatic melanoma, whereas acinic cell, mucoepidermoid, and salivary duct carcinomas were prone to misclassification. Structured FNAC reporting improves diagnostic accuracy and informs personalized surgical planning, reducing interventions and optimizing management.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Mayer, Marcel UNSPECIFIED https://orcid.org/0000-0001-9963-1109 UNSPECIFIED Kourou, Sofia UNSPECIFIED https://orcid.org/0009-0000-2277-4160 UNSPECIFIED Alfarra, Marwan UNSPECIFIED UNSPECIFIED UNSPECIFIED Laatz, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Kevin UNSPECIFIED https://orcid.org/0000-0001-5028-0600 UNSPECIFIED Esser, Julia UNSPECIFIED https://orcid.org/0009-0002-3556-3738 UNSPECIFIED Eckel, Hans Nikolaus Caspar UNSPECIFIED https://orcid.org/0000-0002-6947-9836 UNSPECIFIED Möllenhoff, Kathrin UNSPECIFIED https://orcid.org/0000-0001-7861-3892 UNSPECIFIED Hieggelke, Lena UNSPECIFIED https://orcid.org/0000-0002-1831-0387 UNSPECIFIED Engels, Marianne UNSPECIFIED https://orcid.org/0009-0003-3805-1380 UNSPECIFIED Arolt, Christoph UNSPECIFIED https://orcid.org/0000-0002-6366-2285 UNSPECIFIED Quaas, Alexander UNSPECIFIED https://orcid.org/0000-0002-3537-6011 UNSPECIFIED Wolber, Philipp UNSPECIFIED https://orcid.org/0000-0001-9019-2840 UNSPECIFIED Jansen, Louis UNSPECIFIED https://orcid.org/0000-0003-0332-1099 UNSPECIFIED Nachtsheim, Lisa UNSPECIFIED https://orcid.org/0000-0002-0261-4511 UNSPECIFIED Klussmann, Jens Peter UNSPECIFIED https://orcid.org/0000-0002-8223-7954 UNSPECIFIED Shabli, Sami UNSPECIFIED https://orcid.org/0000-0002-7202-0460 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-802606
Identification Number:	10.1002/cncy.70070
Journal or Publication Title:	Cancer Cytopathology
Volume:	134
Number:	1
Page Range:	pp. 1-8
Number of Pages:	8
Date:	19 January 2026
Publisher:	Wiley
ISSN:	1934-662X
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Hals-Nasen-Ohrenheilkunde > Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Faculty of Medicine > Medizinische Statistik und Bioinformatik
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80260